Chemistry - A European Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 23, 2024
Abstract
Measuring
quinine
is
critical
for
the
detection
of
its
overdose,
understanding
pharmacological
and
toxicological
effects,
monitoring
pollution.
While
a
previously
reported
aptamer
named
MN4
can
bind
quinine,
it
was
not
selected
it,
leading
to
compromised
binding
affinity
specificity.
In
this
work,
new
isolated
using
library
immobilization
capture‐SELEX
technique.
The
Q1
has
K
d
value
10
nM
determined
by
an
isothermal
titration
calorimetry
experiment
45
in
fluorescence
assay.
A
3.5
limit
obtained
based
on
binding‐induced
quenching
intrinsic
quinine.
large
blue
shift
observed
upon
Q1,
whereas
led
very
small
red
shift,
indicating
different
ways
these
two
aptamers.
did
cocaine
NMR
spectroscopy
assays
also
indicated
excellent
selectivity
against
other
tested
molecules.
This
work
supplied
high
that
be
useful
fundamental
studies.
It
highlights
advantages
isolate
aptamers
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
278, P. 116420 - 116420
Published: May 2, 2024
Emerging
contaminants
(ECs)
are
a
diverse
group
of
unregulated
pollutants
increasingly
present
in
the
environment.
These
contaminants,
including
pharmaceuticals,
personal
care
products,
endocrine
disruptors,
and
industrial
chemicals,
can
enter
environment
through
various
pathways
persist,
accumulating
food
chain
posing
risks
to
ecosystems
human
health.
This
comprehensive
review
examines
chemical
characteristics,
sources,
varieties
ECs.
It
critically
evaluates
current
understanding
their
environmental
health
impacts,
highlighting
recent
advancements
challenges
detection
analysis.
The
also
assesses
existing
regulations
policies,
identifying
shortcomings
proposing
potential
enhancements.
ECs
pose
significant
wildlife
by
disrupting
animal
hormones,
causing
genetic
alterations
that
diminish
diversity
resilience,
altering
soil
nutrient
dynamics
physical
Furthermore,
increasing
health,
hormonal
disruptions,
antibiotic
resistance,
disruption,
neurological
effects,
carcinogenic
other
long-term
impacts.
To
address
these
critical
issues,
offers
recommendations
for
future
research,
emphasizing
areas
requiring
further
investigation
comprehend
full
implications
contaminants.
suggests
increased
funding
support
development
advanced
technologies,
establishment
standardized
methods,
adoption
precautionary
regulations,
enhanced
public
awareness
education,
cross-sectoral
collaboration,
integration
scientific
research
into
policy-making.
By
implementing
solutions,
we
improve
our
ability
detect,
monitor,
manage
ECs,
reducing
risks.
