Science,
Journal Year:
2011,
Volume and Issue:
333(6046), P. 1109 - 1112
Published: Aug. 25, 2011
Alterations
of
mitochondrial
functions
are
linked
to
multiple
degenerative
or
acute
diseases.
As
mitochondria
age
in
our
cells,
they
become
progressively
inefficient
and
potentially
toxic,
damage
can
trigger
the
permeabilization
membranes
initiate
apoptosis
necrosis.
Moreover,
have
an
important
role
pro-inflammatory
signaling.
Autophagic
turnover
cellular
constituents,
be
it
general
specific
for
(mitophagy),
eliminates
dysfunctional
damaged
mitochondria,
thus
counteracting
degeneration,
dampening
inflammation,
preventing
unwarranted
cell
loss.
Decreased
expression
genes
that
regulate
autophagy
mitophagy
cause
diseases
which
deficient
quality
control
results
inflammation
death
populations.
Thus,
a
combination
dysfunction
insufficient
may
contribute
aging-associated
pathologies.
Annual Review of Immunology,
Journal Year:
2012,
Volume and Issue:
31(1), P. 51 - 72
Published: Nov. 16, 2012
Depending
on
the
initiating
stimulus,
cancer
cell
death
can
be
immunogenic
or
nonimmunogenic.
Immunogenic
(ICD)
involves
changes
in
composition
of
surface
as
well
release
soluble
mediators,
occurring
a
defined
temporal
sequence.
Such
signals
operate
series
receptors
expressed
by
dendritic
cells
to
stimulate
presentation
tumor
antigens
T
cells.
We
postulate
that
ICD
constitutes
prominent
pathway
for
activation
immune
system
against
cancer,
which
turn
determines
long-term
success
anticancer
therapies.
Hence,
suboptimal
regimens
(failing
induce
ICD),
selective
alterations
(preventing
emission
during
defects
effectors
(abolishing
perception
system)
all
contribute
therapeutic
failure.
surmise
and
its
subversion
pathogens
also
play
major
roles
antiviral
responses.
Cell Research,
Journal Year:
2019,
Volume and Issue:
29(5), P. 347 - 364
Published: April 4, 2019
Cells
may
die
from
accidental
cell
death
(ACD)
or
regulated
(RCD).
ACD
is
a
biologically
uncontrolled
process,
whereas
RCD
involves
tightly
structured
signaling
cascades
and
molecularly
defined
effector
mechanisms.
A
growing
number
of
novel
non-apoptotic
forms
have
been
identified
are
increasingly
being
implicated
in
various
human
pathologies.
Here,
we
critically
review
the
current
state
art
regarding
types
RCD,
including
necroptosis,
pyroptosis,
ferroptosis,
entotic
death,
netotic
parthanatos,
lysosome-dependent
autophagy-dependent
alkaliptosis
oxeiptosis.
The
in-depth
comprehension
each
these
lethal
subroutines
their
intercellular
consequences
uncover
therapeutic
targets
for
avoidance
pathogenic
loss.
