Biological Functions of Autophagy Genes: A Disease Perspective

Cell, Journal Year: 2019, Volume and Issue: 176(1-2), P. 11 - 42

Published: Jan. 1, 2019

Language: Английский

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Oxidative stress and autophagy: the clash between damage and metabolic needs

Cell Death and Differentiation, Journal Year: 2014, Volume and Issue: 22(3), P. 377 - 388

Published: Sept. 26, 2014

Autophagy is a catabolic process aimed at recycling cellular components and damaged organelles in response to diverse conditions of stress, such as nutrient deprivation, viral infection genotoxic stress. A growing amount evidence recent years argues for oxidative stress acting the converging point these stimuli, with reactive oxygen species (ROS) nitrogen (RNS) being among main intracellular signal transducers sustaining autophagy. This review aims providing novel insight into regulatory pathways autophagy glucose amino acid well their tight interconnection metabolic networks redox homeostasis. The role nitrosative also discussed light its harmful both biomolecules mediator through reversible posttranslational modifications thiol-containing proteins. redox-independent relationship between antioxidant response, occurring p62/Keap1/Nrf2 pathway, addressed order provide wide perspective upon Herein, we attempt afford an overview complex crosstalk DNA damage (DDR), focusing on activated ROS RNS overproduction. Along lines, direct indirect DDR dissected depth.

Language: Английский

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Metabolic pathways promoting cancer cell survival and growth

Nature Cell Biology, Journal Year: 2015, Volume and Issue: 17(4), P. 351 - 359

Published: March 16, 2015

Language: Английский

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p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Nature Reviews Molecular Cell Biology, Journal Year: 2015, Volume and Issue: 16(7), P. 393 - 405

Published: June 23, 2015

Language: Английский

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Apoptosis, autophagy, necroptosis, and cancer metastasis

Molecular Cancer, Journal Year: 2015, Volume and Issue: 14(1)

Published: Feb. 20, 2015

Metastasis is a crucial hallmark of cancer progression, which involves numerous factors including the degradation extracellular matrix (ECM), epithelial-to-mesenchymal transition (EMT), tumor angiogenesis, development an inflammatory microenvironment, and defects in programmed cell death. Programmed death, such as apoptosis, autophagy, necroptosis, plays roles metastatic processes. Malignant cells must overcome these various forms death to metastasize. This review summarizes recent advances understanding mechanisms by key regulators necroptosis participate metastasis discusses crosstalk between involved regulation metastasis.

Language: Английский

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Ferroptosis: mechanisms and links with diseases

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Feb. 3, 2021

Abstract Ferroptosis is an iron-dependent cell death, which different from apoptosis, necrosis, autophagy, and other forms of death. The process ferroptotic death defined by the accumulation lethal lipid species derived peroxidation lipids, can be prevented iron chelators (e.g., deferiprone, deferoxamine) small lipophilic antioxidants ferrostatin, liproxstatin). This review summarizes current knowledge about regulatory mechanism ferroptosis its association with several pathways, including iron, lipid, cysteine metabolism. We have further discussed contribution to pathogenesis diseases such as cancer, ischemia/reperfusion, various neurodegenerative Alzheimer’s disease Parkinson’s disease), evaluated therapeutic applications inhibitors in clinics.

Language: Английский

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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

Cell Death and Differentiation, Journal Year: 2014, Volume and Issue: 22(1), P. 58 - 73

Published: Sept. 19, 2014

Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such unavoidable variant cellular demise is generally referred 'accidental cell death' (ACD). In most settings, however, death initiated by genetically encoded apparatus, correlating with the fact that its course can be altered pharmacologic genetic interventions. 'Regulated (RCD) occur part physiologic programs activated once adaptive responses perturbations extracellular intracellular microenvironment fail. The biochemical phenomena accompany RCD may harnessed classify it into few subtypes, which often (but not always) exhibit stereotyped morphologic features. Nonetheless, efficiently inhibiting processes are commonly thought cause RCD, such activation executioner caspases apoptosis, does exert true cytoprotective effects mammalian system, but simply alters kinetics shifts and correlates. Conversely, bona fide cytoprotection achieved transduction lethal signals early phases process, when still operational. Thus, mechanisms truly execute less understood, inhibitable perhaps more homogeneous than previously thought. Here, Nomenclature Committee on Cell Death formulates set recommendations help scientists researchers discriminate between essential accessory aspects death.

Language: Английский

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The role of necroptosis in cancer biology and therapy

Molecular Cancer, Journal Year: 2019, Volume and Issue: 18(1)

Published: May 23, 2019

Apoptosis resistance is to a large extent major obstacle leading chemotherapy failure during cancer treatment. Bypassing the apoptotic pathway induce cell death considered be promising approach overcoming this problem. Necroptosis regulated necrotic modality in caspase-independent fashion and mainly mediated by Receptor-Interacting Protein 1 (RIP1), RIP3, Mixed Lineage Kinase Domain-Like (MLKL). serves as an alternative mode of programmed apoptosis may trigger amplify antitumor immunity therapy. The role necroptosis complicated. expression key regulators necroptotic generally downregulated cells, suggesting that cells also evade survive; however, certain types cancer, level mediators elevated. can elicit strong adaptive immune responses defend against tumor progression; recruited inflammatory response promote tumorigenesis metastasis, generate immunosuppressive microenvironment. reportedly promotes oncogenesis metastasis despite evidence demonstrating its antimetastatic cancer. In addition, microenvironments direct lineage commitment determine subtype development liver A plethora compounds drugs targeting exhibit potential efficacy, but their clinical feasibility must validated. Better knowledge mechanism physiological pathological functions urgently required solve remaining mysteries surrounding review, we briefly introduce molecular characteristics necroptosis, interplay between other mechanisms, crosstalk metabolic signaling detection methods. We summarize intricate progression, prognosis patients, regulation, determination therapeutics.

Language: Английский

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Ferroptosis is a type of autophagy-dependent cell death

Seminars in Cancer Biology, Journal Year: 2019, Volume and Issue: 66, P. 89 - 100

Published: March 14, 2019

Language: Английский

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Senescence and apoptosis: dueling or complementary cell fates?

EMBO Reports, Journal Year: 2014, Volume and Issue: 15(11), P. 1139 - 1153

Published: Oct. 13, 2014

Language: Английский

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