npj Vaccines,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 10, 2024
Immunosenescence
increases
the
risk
and
severity
of
diseases
in
elderly
individuals
leads
to
impaired
vaccine-induced
immunity.
With
aging
global
population
emerging
epidemics,
developing
adjuvants
vaccines
for
improve
their
immune
protection
is
pivotal
healthy
worldwide.
Deepening
our
understanding
role
immunosenescence
vaccine
efficacy
could
accelerate
research
focused
on
optimizing
delivery
individuals.
In
this
review,
we
analyzed
characteristics
at
cellular
molecular
levels.
Strategies
vaccination
potency
are
summarized,
including
increasing
antigen
dose,
preparing
multivalent
vaccines,
adding
appropriate
adjuvants,
inhibiting
chronic
inflammation,
immunosenescence.
We
hope
that
review
can
provide
a
new
findings
with
regards
impacts
vaccine-mediated
inspire
development
individualized
Annual Review of Biochemistry,
Journal Year:
2023,
Volume and Issue:
92(1), P. 435 - 464
Published: April 5, 2023
The
polyamines
putrescine,
spermidine,
and
spermine
are
abundant
polycations
of
vital
importance
in
mammalian
cells.
Their
cellular
levels
tightly
regulated
by
degradation
synthesis,
as
well
uptake
export.
Here,
we
discuss
the
delicate
balance
between
neuroprotective
neurotoxic
effects
context
Parkinson's
disease
(PD).
Polyamine
decline
with
aging
altered
patients
PD,
whereas
recent
mechanistic
studies
on
ATP13A2
(PARK9)
demonstrated
a
driving
role
disturbed
polyamine
homeostasis
PD.
Polyamines
affect
pathways
PD
pathogenesis,
such
α-synuclein
aggregation,
influence
PD-related
processes
like
autophagy,
heavy
metal
toxicity,
oxidative
stress,
neuroinflammation,
lysosomal/mitochondrial
dysfunction.
We
formulate
outstanding
research
questions
regarding
their
potential
biomarkers,
possible
therapeutic
strategies
for
targeting
homeostasis.
Nature Cell Biology,
Journal Year:
2024,
Volume and Issue:
26(9), P. 1571 - 1584
Published: Aug. 8, 2024
Abstract
Caloric
restriction
and
intermittent
fasting
prolong
the
lifespan
healthspan
of
model
organisms
improve
human
health.
The
natural
polyamine
spermidine
has
been
similarly
linked
to
autophagy
enhancement,
geroprotection
reduced
incidence
cardiovascular
neurodegenerative
diseases
across
species
borders.
Here,
we
asked
whether
cellular
physiological
consequences
caloric
depend
on
metabolism.
We
report
that
levels
increased
upon
distinct
regimens
or
in
yeast,
flies,
mice
volunteers.
Genetic
pharmacological
blockade
endogenous
synthesis
fasting-induced
nematodes
cells.
Furthermore,
perturbing
pathway
vivo
abrogated
lifespan-
healthspan-extending
effects,
as
well
cardioprotective
anti-arthritic
fasting.
Mechanistically,
mediated
these
effects
via
induction
hypusination
translation
regulator
eIF5A.
In
summary,
polyamine–hypusination
axis
emerges
a
phylogenetically
conserved
metabolic
control
hub
for
fasting-mediated
enhancement
longevity.
npj Vaccines,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: April 10, 2024
Immunosenescence
increases
the
risk
and
severity
of
diseases
in
elderly
individuals
leads
to
impaired
vaccine-induced
immunity.
With
aging
global
population
emerging
epidemics,
developing
adjuvants
vaccines
for
improve
their
immune
protection
is
pivotal
healthy
worldwide.
Deepening
our
understanding
role
immunosenescence
vaccine
efficacy
could
accelerate
research
focused
on
optimizing
delivery
individuals.
In
this
review,
we
analyzed
characteristics
at
cellular
molecular
levels.
Strategies
vaccination
potency
are
summarized,
including
increasing
antigen
dose,
preparing
multivalent
vaccines,
adding
appropriate
adjuvants,
inhibiting
chronic
inflammation,
immunosenescence.
We
hope
that
review
can
provide
a
new
findings
with
regards
impacts
vaccine-mediated
inspire
development
individualized
