Cells,
Journal Year:
2025,
Volume and Issue:
14(7), P. 499 - 499
Published: March 27, 2025
Cellular
senescence
is
an
irreversible
state
of
cell
cycle
arrest.
Senescent
cells
(SCs)
accumulate
in
the
body
with
age
and
secrete
harmful
substances
known
as
senescence-associated
secretory
phenotype
(SASP),
causing
chronic
inflammation;
at
same
time,
inflammation
leads
to
a
decrease
immune
system
function,
immunosenescence,
which
further
accelerates
aging
process.
immunosenescence
are
closely
related
variety
diseases,
including
cardiovascular
metabolic
disorders,
autoimmune
neurodegenerative
diseases.
Studying
mechanisms
cellular
developing
targeted
interventions
crucial
for
improving
function
quality
life
elderly
people.
Here,
we
review
series
recent
studies
focusing
on
molecular
regulation
by
system,
latest
advances
basic
clinical
research
senolytics.
We
summarize
animal
models
research,
well
mechanisms,
strategies,
future
directions
from
immunological
perspective,
hope
laying
foundation
novel
practical
anti-aging
therapies.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: May 18, 2024
Abstract
Aging
and
cancer
exhibit
apparent
links
that
we
will
examine
in
this
review.
The
null
hypothesis
aging
coincide
because
both
are
driven
by
time,
irrespective
of
the
precise
causes,
can
be
confronted
with
idea
share
common
mechanistic
grounds
referred
to
as
‘hallmarks’.
Indeed,
several
hallmarks
also
contribute
carcinogenesis
tumor
progression,
but
some
molecular
cellular
characteristics
may
reduce
probability
developing
lethal
cancer,
perhaps
explaining
why
very
old
age
(>
90
years)
is
accompanied
a
reduced
incidence
neoplastic
diseases.
We
discuss
possibility
process
itself
causes
meaning
time-dependent
degradation
supracellular
functions
accompanies
produces
byproduct
or
‘age-associated
disease’.
Conversely,
its
treatment
erode
health
drive
process,
has
dramatically
been
documented
for
survivors
diagnosed
during
childhood,
adolescence,
young
adulthood.
conclude
connected
superior
including
endogenous
lifestyle
factors,
well
bidirectional
crosstalk,
together
render
not
only
risk
factor
an
important
parameter
must
considered
therapeutic
decisions.
Journal of Molecular Medicine,
Journal Year:
2024,
Volume and Issue:
102(6), P. 733 - 750
Published: April 11, 2024
Abstract
The
accumulation
of
senescent
cells
within
tissues
is
a
hallmark
the
aging
process.
Senescent
are
also
commonly
present
in
many
age-related
diseases
and
cancer
microenvironment.
escape
abnormal
from
immune
surveillance
indicates
that
there
some
defect
function
cytotoxic
cells,
e.g.,
CD8
+
T
natural
killer
(NK)
cells.
Recent
studies
have
revealed
expression
programmed
death-ligand
1
(PD-L1)
protein
abundantly
increased
An
increase
amount
PD-L1
protects
clearance
by
PD-1
checkpoint
receptor
In
fact,
activation
suppresses
properties
NK
promoting
state
immunosenescence.
inhibitory
PD-1/PD-L1
pathway
acts
cooperation
with
immunosuppressive
cells;
for
example,
can
enhance
differentiation
regulatory
(Treg),
myeloid-derived
suppressor
(MDSC),
M2
macrophages,
whereas
cytokines
secreted
stimulate
protein.
Interestingly,
signaling
pathways
known
to
promote
cellular
senescence
process
crucial
stimulators
protein,
epigenetic
regulation,
inflammatory
mediators,
mTOR-related
signaling,
cGAS-STING
pathway,
AhR
signaling.
It
seems
axis
has
role
thus
it
promotes
tissues.
Thus,
blockade
might
be
potential
anti-aging
senolytic
therapy.
Key
messages
accumulate
during
diseases.
able
Expression
markedly
increases
Age-related
stimulates
Inhibitory
Signal Transduction and Targeted Therapy,
Journal Year:
2025,
Volume and Issue:
10(1)
Published: March 7, 2025
Redox
signaling
acts
as
a
critical
mediator
in
the
dynamic
interactions
between
organisms
and
their
external
environment,
profoundly
influencing
both
onset
progression
of
various
diseases.
Under
physiological
conditions,
oxidative
free
radicals
generated
by
mitochondrial
respiratory
chain,
endoplasmic
reticulum,
NADPH
oxidases
can
be
effectively
neutralized
NRF2-mediated
antioxidant
responses.
These
responses
elevate
synthesis
superoxide
dismutase
(SOD),
catalase,
well
key
molecules
like
nicotinamide
adenine
dinucleotide
phosphate
(NADPH)
glutathione
(GSH),
thereby
maintaining
cellular
redox
homeostasis.
Disruption
this
finely
tuned
equilibrium
is
closely
linked
to
pathogenesis
wide
range
Recent
advances
have
broadened
our
understanding
molecular
mechanisms
underpinning
dysregulation,
highlighting
pivotal
roles
genomic
instability,
epigenetic
modifications,
protein
degradation,
metabolic
reprogramming.
findings
provide
foundation
for
exploring
regulation
mechanistic
basis
improving
therapeutic
strategies.
While
antioxidant-based
therapies
shown
early
promise
conditions
where
stress
plays
primary
pathological
role,
efficacy
diseases
characterized
complex,
multifactorial
etiologies
remains
controversial.
A
deeper,
context-specific
signaling,
particularly
redox-sensitive
proteins,
designing
targeted
aimed
at
re-establishing
balance.
Emerging
small
molecule
inhibitors
that
target
specific
cysteine
residues
proteins
demonstrated
promising
preclinical
outcomes,
setting
stage
forthcoming
clinical
trials.
In
review,
we
summarize
current
intricate
relationship
disease
also
discuss
how
these
insights
leveraged
optimize
strategies
practice.
Foods,
Journal Year:
2024,
Volume and Issue:
13(15), P. 2441 - 2441
Published: Aug. 2, 2024
Aging
is
a
natural
and
irreversible
process,
affecting
living
organisms
by
negatively
impacting
the
tissues'
cells'
morphology
functionality
consequently
being
responsible
for
aging-related
diseases.
Taking
into
account
actual
preoccupations
of
both
consumers
researchers,
healthy
anti-aging
alternatives
are
intensively
studied
in
order
to
address
such
concerns.
Due
their
functional
features,
plant
flavonoids
can
be
considered
valuable
nutraceuticals.
This
paper
highlights
possibilities
use
extracted
from
various
plants
potential
on
skin,
brain,
heart.
Moreover,
anticarcinogenic,
anti-inflammatory,
anti-diabetic
properties
summarized,
along
with
senescence-associated
mechanisms.
Both
nutraceutical
cosmeceutical
fields
continuously
developing
originating
promising
candidates
obtain
products.
Thus,
bioactive
compounds'
extraction
subsequent
involvement
innovative
product
manufacturing
must
carefully
performed
while
aware
intrinsic
extrinsic
factors
that
may
affect
phytochemicals'
structures,
bioavailability,
health
effects.
GeroScience,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
One
promising
strategy
to
alleviate
aging
symptoms
is
the
treatment
with
senolytics
that
compounds
which
selectively
eliminate
senescent
cells.
Some
therapies
aim
reduce
of
cellular
senescence
without
cell
eradication
(senomorphic
activity).
However,
senotherapies
raise
many
questions
concerning
selectivity,
safety
and
efficiency
senolitic
drugs.
A
vital
question
how
senolytic
affect
young
proliferating
In
our
study,
we
checked
impact
quercetin
dasatinib
(D
+
Q),
one
drug
mixtures
drugs,
on
chromatin
structure
in
We
analyzed
effect
a
single
triple
vascular
smooth
muscle
have
shown
D
Q
impacts
both
cells,
caused
some
“rejuvenation”
but
cells
changes
characteristic
were
observed.
The
alterations
appeared
only
transiently
returned
initial
state
after
24
h
recovery.
complexity
staining
nucleus
morphology
evaluation
indicated
makes
more
similar
ones
than
treatment.
analysis
markers
suggested
slightly
less
pronounced
characteristics
was
efficient
alleviating
features
It
still
an
open
whether
by
are
beneficial
or
harmful
long
term;
however,
so
far,
it
can
be
concluded
effects
depend
type
physiological
context.
Aging Cell,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 9, 2025
ABSTRACT
Longevity
individuals
have
lower
susceptibility
to
chronic
hypoxia,
inflammation,
oxidative
stress,
and
aging‐related
diseases.
It
has
long
been
speculated
that
“rejuvenation
molecules”
exist
in
their
blood
promote
extended
lifespan.
We
unexpectedly
discovered
longevity
exhibit
erythrocyte
oxygen
release
function
similar
young
individuals,
whereas
most
elderly
show
reduced
capacity.
Untargeted
metabolomics
profiling
revealed
are
characterized
by
youth‐like
metabolic
reprogramming
these
metabolites
effectively
differentiate
the
from
elderly.
Quantification
analyses
led
us
identify
multiple
novel
longevity‐related
within
erythrocytes
including
adenosine,
sphingosine‐1‐phosphate
(S1P),
glutathione
(GSH)
related
amino
acids.
Mechanistically,
we
increased
bisphosphoglycerate
mutase
(BPGM)
MFSD2B
protein
levels
of
collaboratively
work
together
induce
elevation
intracellular
S1P,
glyceraldehyde‐3‐phosphate
dehydrogenase
(GAPDH)
membrane
cytosol,
thereby
orchestrate
glucose
toward
Rapoport–Luebering
Shunt
2,3‐BPG
production
trigger
delivery.
Furthermore,
glutamine
glutamate
transporter
expression
coupled
with
enhanced
metabolism
underlie
elevated
GSH
higher
anti‐oxidative
stress
capacity
individuals.
As
such,
displayed
less
systemic
hypoxia‐related
more
antioxidative
anti‐inflammatory
plasma,
healthier
clinical
outcomes
inflammation
parameters
as
well
better
glucose–lipid
metabolism,
liver
kidney
function.
Overall,
identified
youthful
enable
counteract
peripheral
tissue
thus
maintaining
healthspan.
Aging and Disease,
Journal Year:
2025,
Volume and Issue:
unknown, P. 0 - 0
Published: Jan. 1, 2025
Age-related
diseases
have
emerged
as
a
global
concern
the
population
ages.
Consequently,
understanding
underlying
causes
of
aging
and
exploring
potential
anti-aging
interventions
is
imperative.
In
females,
ovaries
serve
principal
organs
responsible
for
ovulation
production
female
hormones.
The
are
related
to
infertility,
menopause,
associated
menopausal
syndromes,
with
menopause
representing
culmination
ovarian
aging.
Current
evidence
indicates
that
may
contribute
dysfunction
across
multiple
organ
systems,
including,
but
not
limited
to,
cognitive
impairment,
osteoporosis,
cardiovascular
disease.
Nevertheless,
due
widespread
distribution
sex
hormone
receptors
throughout
body,
affects
only
these
specific
also
influences
broader
spectrum
age-related
in
women.
Despite
this,
impact
on
overall
has
been
largely
neglected.
This
review
provides
thorough
summary
diseases,
encompassing
nervous,
circulatory,
locomotor,
urinary,
digestive,
respiratory,
endocrine
systems.
Additionally,
we
outlined
prospective
therapeutic
approaches
addressing
both
aim
mitigating
their
impacts
preserving
women's
fertility,
physical
health,
psychological
well-being.
