Antioxidants,
Journal Year:
2023,
Volume and Issue:
12(2), P. 213 - 213
Published: Jan. 17, 2023
During
recent
decades,
the
complexation
of
organic
ligands
toward
several
metal
ions
s-p
and
d-block
has
been
applied
as
a
plan
to
enhance
its
antioxidant
performance.
Due
their
wide
range
beneficial
impacts,
coordination
compounds
are
widely
used
in
industries,
specifically
medicinal
pharmaceutical
fields.
The
activity
is
generally
improved
by
chelation
consequently
knowing
that
characteristics
both
metals
can
lead
development
greatly
active
compounds.
Chelation
substitute
for
using
traditional
synthetic
antioxidants,
because
chelates
present
benefits,
including
variety
geometry,
oxidation
states,
number,
assist
favor
redox
methods
associated
with
action.
As
well
understanding
best
studied
anti-oxidative
assets
these
compounds,
involved
free
radical
scavenging
process
protecting
human
organisms
from
opposing
effects
radicals.
ability
be
assessed
various
interrelated
systems.
methodological
modification
offers
most
knowledge
on
property
chelates.
Colorimetric
techniques
used,
though
electron
paramagnetic
resonance
(EPR)
an
alternative
metallic
since
color
does
not
affect
results.
Information
about
systems,
restrictions,
permits
dependable
valuation
performance
assisting
application
states
wherever
drugs
required,
such
food
protection,
appropriate
good-packaged
foods,
dietary
supplements,
others.
Because
new
exhaustive
analysis
ligands,
it
become
separate
field
research
chemistry.
investigation
will
respected
providing
foundation
properties
future
tests
building
high-quality
antioxidative
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(6)
Published: April 25, 2024
Novel
divalent
chelates
of
Co
(II),
Cu
Zn
(II)
and
Ni
were
prepared
described
the
form
[M
(NTM)(CH
3
COO)
2
]
where
NTM
=
[1‐(4‐nitrophenyl)‐1H‐1,2,3‐triazol‐4‐yl)methanol
ligand.
Elemental
analyses,
infrared
red,
1
H
13
CNMR,
electronic,
magnetic
susceptibility,
conductivity
measurements
X‐ray
diffraction
studies
used
to
assess
our
metal
complexes.
Moreover,
stability
stoichiometry
novel
examined
through
job's
method
in
solutions.
Correlation
all
spectroscopic
techniques
states
that
acts
as
a
bi‐dentate
NO
ligand
afford
octahedral
complex
geometry
for
investigated
chelates.
Thermodynamic
kinetics
factors
various
thermal
degradation
phases
calculated.
B3LYP/LANL2DZ/6‐311
g(d,p)
theoretical
study
has
been
applied
estimating
MEP
quantum
chemical
reactivity
descriptors
studied
molecules.
UV–Vis
absorption
spectra
molecules
are
predicted
via
time‐dependent
DFT
(TD‐DFT)
calculations.
In
addition,
MOE‐
docking
was
tested
on
two
different
proteins,
receptor
(3HB5)
breast
cancer
mutant
oxidoreductase
well
Glucosamine‐6‐phosphate
synthase
with
glucosamine‐6‐
phosphate
(2VF5)
E.coli
COVID‐19
protease.
The
results
recommended
(NTMCo),
(NTMNi),
(NTMCu)
(NTMZn)
complexes
showed
highest
inhibitory
activity
compared
other
ligands
antimicrobial
candidates.
Furthermore,
in‐vitro
anti‐bacterial,
anti‐fungal,
cytotoxic
anti‐oxidant
performances
selected
its
studied.
All
presented
superiority,
proceeding
free
organic
ineffective
management,
definitely
NTMCu
complex.
Applied Organometallic Chemistry,
Journal Year:
2024,
Volume and Issue:
38(3)
Published: Jan. 8, 2024
New
Cu
(II),
VO
Ag(I),
and
Pd
(II)‐[BIP
=
4,6‐dimethyl‐N‐(octahydro‐2H‐benzimidazol‐2‐ylidene)pyrimidin‐2‐amine]
chelates
have
been
synthesized
by
the
reaction
of
BIP
ligand
resulting
from
condensation
benzimidazole
guanidine
as
well
acetylacetone
with
tested
metal
salts.
The
suggested
structures
prepared
compounds
investigated
spectroscopically
through
(FT‐IR,
NMR,
Mass
spectra,
UV–Vis
spectra),
CHN
analyses,
conductivity,
pH
stability
asmagnetic
moment
measurements.
TGA
studies
also
studied
to
govern
thermal
behavior,
stability,
decomposition
chelates.
Structural
study
exposed
their
chemical
transformation
chelation
metals.
predicted
a
hexa‐coordinated
geometry
for
chelates,
whereas
tetra‐coordinated
Ag
DFT/B3LYP
theoretical
method
was
applied
obtain
optimized
geometry,
molecular
electrostatic
potential
(MEP)
surface,
HOMO‐LUMO
analysis
compounds.
For
estimation
in
vitro
study,
all
screened
biochemical
features,
including
antioxidant,
antimicrobial
performances,
cytotoxicity.
antioxidant
performance
molecules
has
DPPH
displayed
close
against
standard
drugs.
cytotoxic
estimated
various
cancer
cell
lines:
(Hep‐G2,
HCT‐116,
MCF‐7)
using
MTT
calculated
viability
corresponding
human
cell.
DNA
binding
capability
evaluated
absorption
spectroscopic,
viscosity
estimation,
gel
electrophoresis.
outcomes
good
tendency
constant
1.01
×
10
4
1.99
M
−1
order
BIPCu>
BIPVO
>
BIPPd
BIPAg,
respectively.
Finally,
docking
simulation
results
indicated
that
complexes
were
located
intercalation
site
confirmed
experimental
findings.
