Quality by Design Approach for the Formulation and Evaluation of Stem Cells Derived Rosmarinic Acid-Loaded Nanofibers as an Anti-Wrinkle Patch: In Vitro and In Vivo Characterizations DOI Creative Commons
Rehab Abdelmonem,

Ahmed Bakr,

Ingy Badawy

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1598 - 1598

Published: Dec. 16, 2024

Background/Objectives: Skin wrinkles result from a myriad of multifaceted processes involving intrinsic and extrinsic aging. To combat this effect, plant stem cells offer renewable eco-friendly source for various industries, including cosmeceuticals. Salvia miltiorrhiza (SM), which contains the bioactive compound Rosmarinic acid (RA) has been proposed its anti-wrinkle effect. Methods: In present study, calli SM were cultured Quality by Design (QbD) was implemented to investigate effect different types concentrations elicitors; jasmonic (JA) salicylic (SA). Both raised RA levels yet, (50 µM) resulted in highest yield RA, at 16 mg/g. A nanofiber patch prepared characterized in-vitro release percentage, drug content, swelling degree, scanning electron microscope, surface roughness. Then, tested UV wrinkle-induced mouse model. Results: Interestingly, after treatment, there visibly fewer wrinkles, skin softer than untreated control group. This study suggests that treatment exerted through Nrf2/Keap1 pathway, plays crucial role cellular antioxidant protective processes. By activating pathway boosting Nrf2 diminishing Keap1 enhances production enzymes, such as superoxide dismutase glutathione peroxidase, enhancesglutathione, reduces lipid peroxidation, collectively indicating enhanced quality. Conclusions: conclusion, highlights importance formula an future clinical studies are recommended further unveil potential formula.

Language: Английский

Aloe vera and its byproducts as sources of valuable bioactive compounds: Extraction, biological activities, and applications in various food industries DOI Creative Commons
Emmanuel O. Mensah, Parise Adadi, Richard Vincent Asase

et al.

PharmaNutrition, Journal Year: 2025, Volume and Issue: unknown, P. 100436 - 100436

Published: Feb. 1, 2025

Language: Английский

Citations

1
Microemulsion gel systems: Formulation, stability studies, biopolymer interactions, and functionality in food product development DOI Open Access

Janice Adaeze Nwankwo,

Wenxue Liu,

Xiusheng Guo

et al.

Comprehensive Reviews in Food Science and Food Safety, Journal Year: 2025, Volume and Issue: 24(2)

Published: Feb. 3, 2025

Abstract Microemulsion gels (MGs) are nanostructured systems created by the addition of thickening agents/biopolymers to a microemulsion's aqueous or oily phases, offering benefits like improved solubilization, enhanced stability, high encapsulation efficiency, and sustained release with versatile applications in food, pharmaceuticals, cosmetology. MGs intricate thermodynamic robustness controllable rheological characteristics crucial for obtaining structural integrity achieving innovative results regarding food product development diverse areas including colloidal carriers, packaging, active compound delivery, antimicrobial vectors, production biopolymer nanoparticles. Therefore, comprehensive analysis, hence understanding about MG systems, is needed identify trends gaps, helping researchers promising innovation providing direction future research. This review offers analysis their characteristics, formulation, formation mechanisms, design approaches, digestion dynamics, properties. excel solubilizing hydrophilic lipophilic bioactives due viscosity interconnected droplet network within gel matrix. Despite advantages, challenges, such as formulation complexity, require further understanding. article also explores biopolymers, characterization, extensive applications, while addressing case studies, emerging leveraging potential enhancing functionality, nutritional value.

Language: Английский

Citations

0
Evaluation of novel microemulsions and microemulgels containing herbal oils as skin care and topical drug delivery systems for celecoxib DOI

Nesa Ghorbani,

Alireza Salabat

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: unknown, P. 127163 - 127163

Published: Feb. 1, 2025

Language: Английский

Citations

0
Extraction and Characterization of Novel Alternative Cellulosic Fiber for Sustainable Textiles from Aloe barbadensis Miller Stems (Agricultural Waste) DOI Creative Commons
Hammad Majeed, Tehreema Iftikhar,

Rehman Manzoor

et al.

Heliyon, Journal Year: 2024, Volume and Issue: unknown, P. e37428 - e37428

Published: Sept. 1, 2024

Language: Английский

Citations

2
Study on the application of Aloe vera in cosmetology and clinical treatment of skin diseases DOI Creative Commons
Jiajun Zhu,

Yuanru Zheng,

Yanhui Ge

et al.

Journal of Holistic Integrative Pharmacy, Journal Year: 2024, Volume and Issue: 5(4), P. 299 - 304

Published: Dec. 1, 2024

Language: Английский

Citations

1
Recent technology interventions for agronomic traits enhancement in Indian mustard [Brassica juncea (L.) Czern. & Coss.] DOI
Aman Verma,

Monika Bakoliya,

Rajpal Choudhary

et al.

Scientia Horticulturae, Journal Year: 2024, Volume and Issue: 338, P. 113542 - 113542

Published: Aug. 10, 2024

Language: Английский

Citations

0
Quality by Design Approach for the Formulation and Evaluation of Stem Cells Derived Rosmarinic Acid-Loaded Nanofibers as an Anti-Wrinkle Patch: In Vitro and In Vivo Characterizations DOI Creative Commons
Rehab Abdelmonem,

Ahmed Bakr,

Ingy Badawy

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(12), P. 1598 - 1598

Published: Dec. 16, 2024

Background/Objectives: Skin wrinkles result from a myriad of multifaceted processes involving intrinsic and extrinsic aging. To combat this effect, plant stem cells offer renewable eco-friendly source for various industries, including cosmeceuticals. Salvia miltiorrhiza (SM), which contains the bioactive compound Rosmarinic acid (RA) has been proposed its anti-wrinkle effect. Methods: In present study, calli SM were cultured Quality by Design (QbD) was implemented to investigate effect different types concentrations elicitors; jasmonic (JA) salicylic (SA). Both raised RA levels yet, (50 µM) resulted in highest yield RA, at 16 mg/g. A nanofiber patch prepared characterized in-vitro release percentage, drug content, swelling degree, scanning electron microscope, surface roughness. Then, tested UV wrinkle-induced mouse model. Results: Interestingly, after treatment, there visibly fewer wrinkles, skin softer than untreated control group. This study suggests that treatment exerted through Nrf2/Keap1 pathway, plays crucial role cellular antioxidant protective processes. By activating pathway boosting Nrf2 diminishing Keap1 enhances production enzymes, such as superoxide dismutase glutathione peroxidase, enhancesglutathione, reduces lipid peroxidation, collectively indicating enhanced quality. Conclusions: conclusion, highlights importance formula an future clinical studies are recommended further unveil potential formula.

Language: Английский

Citations

0