The Neoteric Paradigm of Biomolecule-Functionalized Albumin-Based Targeted Cancer Therapeutics DOI

Swati Gunjkar,

Ujala Gupta, R. Nair

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(8)

Published: Nov. 5, 2024

Language: Английский

Improving the therapeutic window of anticancer agents by β-cyclodextrin encapsulation: Experimental and theoretical insights DOI
Nilima Priyadarsini Mishra, Dipak Kumar Sahoo, Seetaram Mohapatra

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 404, P. 124967 - 124967

Published: May 12, 2024

Language: Английский

Citations

4
Formation of amygdalin/β-cyclodextrin derivatives inclusion complexes for anticancer activity assessment in human cervical carcinoma HeLa cell line DOI
V. Meenatchi, Kannan Badri Narayanan, Ankur Sood

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 662, P. 124293 - 124293

Published: May 31, 2024

Language: Английский

Citations

4
Molecular Modeling Study of Interactions in the Supramolecular System Dihydroquercetin–β-Cyclodextrin DOI

Hassina Chekroud,

Abdelaziz Bouhadiba,

Noura Naili

et al.

Russian Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 61(1), P. 162 - 170

Published: Jan. 1, 2025

Language: Английский

Citations

0
Nerolidol loaded beta cyclodextrin nanoparticles: a promising strategy for inducing apoptosis in breast cancer cells (MCF-7) DOI
Kamalesh Balakumar Venkatesan,

Saravanan Alamelu,

Manoj Kumar Srinivasan

et al.

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31

Published: May 6, 2025

This study investigates the synthesis, characterization and anticancer efficacy of nerolidol-loaded beta cyclodextrin polymeric nanoparticles (NER-βCD-NPs) against MCF-7 breast cancer cells. Nerolidol, a sesquiterpene with anti-inflammatory, antioxidant, antimicrobial properties, faces challenges poor solubility bioavailability, limiting its therapeutic potential. Breast cancer, leading cause cancer-related deaths in women, necessitates alternative therapies fewer side effects compared to conventional chemotherapy. NER-βCD-NPs were synthesized characterized using UV-visible spectroscopy, fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), dynamic light scattering (DLS), zeta potential analysis differential calorimetry (DSC). Drug encapsulation efficiency vitro release analyzed HPLC, while molecular docking assessed NER-βCD interactions. Characterization confirmed successful nanoparticle synthesis. spectra FTIR indicated encapsulation-specific changes, SEM revealed surface morphology, DLS, DSC analyses demonstrated increased size stability. The was 84.9%, 86% NER at pH 5.4 over 48 h. Docking studies supported strong binding between βCD (binding energy: -3.55 kcal/mol). Cytotoxicity assays showed significant cell inhibition. Mechanistic reactive oxygen species (ROS) generation, mitochondrial dysfunction, nuclear changes cycle arrest G0-G1 phase. Molecular apoptosis through upregulation Bax, Caspase 6, 9 Cytochrome c, alongside Bcl-2 downregulation. These results highlight as promising strategy for therapy, offering targeted delivery enhanced mitigating nerolidol limitations. Further are warranted validate their clinical applications.

Language: Английский

Citations

0
Harnessing the targeting potential of hyaluronic acid for augmented anticancer activity and safety of duvelisib-loaded nanoparticles in hematological malignancies DOI
Srushti Mahajan, Mayur Aalhate,

Essha Chatterjee

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 136600 - 136600

Published: Oct. 18, 2024

Language: Английский

Citations

1
The Neoteric Paradigm of Biomolecule-Functionalized Albumin-Based Targeted Cancer Therapeutics DOI

Swati Gunjkar,

Ujala Gupta, R. Nair

et al.

AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(8)

Published: Nov. 5, 2024

Language: Английский

Citations

0