Mechanisms and consequences of endothelial cell senescence

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(1), P. 38 - 51

Published: July 19, 2022

Language: Английский

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Sulfide regulation of cardiovascular function in health and disease

Nature Reviews Cardiology, Journal Year: 2022, Volume and Issue: 20(2), P. 109 - 125

Published: Aug. 5, 2022

Language: Английский

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Renal microvascular endothelial cell responses in sepsis-induced acute kidney injury

Nature Reviews Nephrology, Journal Year: 2021, Volume and Issue: 18(2), P. 95 - 112

Published: Oct. 19, 2021

Language: Английский

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Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation

Cells, Journal Year: 2022, Volume and Issue: 11(12), P. 1935 - 1935

Published: June 15, 2022

Systemic inflammation can be triggered by infection, surgery, trauma or burns. During systemic inflammation, an overshooting immune response induces tissue damage resulting in organ dysfunction and mortality. Endothelial cells make up the inner lining of all blood vessels are critically involved maintaining integrity regulating perfusion. Permeability endothelial monolayer is strictly controlled highly organ-specific, forming continuous, fenestrated discontinuous capillaries that orchestrate extravasation fluids, proteins solutes to maintain homeostasis. In physiological state, barrier maintained glycocalyx, extracellular matrix intercellular junctions including adherens tight junctions. As constantly sensing responding environment, their activation inflammatory stimuli promotes a loss function, which has been identified as hallmark leading edema formation hypotension thus, key contributor lethal outcomes. this review, we provide comprehensive summary major players, such angiopoietin-Tie2 signaling axis, adrenomedullin vascular (VE-) cadherin, substantially contribute regulation dysregulation permeability during elucidate treatment strategies targeting preservation integrity.

Language: Английский

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Controlling the biodistribution and clearance of nanomedicines

Nature Reviews Bioengineering, Journal Year: 2023, Volume and Issue: 2(3), P. 214 - 232

Published: Dec. 20, 2023

Language: Английский

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Bioinspired Ice-Binding Materials for Tissue and Organ Cryopreservation

Journal of the American Chemical Society, Journal Year: 2022, Volume and Issue: 144(13), P. 5685 - 5701

Published: March 24, 2022

Cryopreservation of tissues and organs can bring transformative changes to medicine medical science. In the past decades, limited progress has been achieved, although cryopreservation long intensively pursued. One key reason is that cryoprotective agents (CPAs) currently used for cell cannot effectively preserve because their cytotoxicity tissue destructive effect as well low efficiency in controlling ice formation. stark contrast, nature its unique ways formation, many living organisms prevent freezing damage. Ice-binding proteins (IBPs) are regarded essential materials identified these regulating nucleation growth. Note controversial results have reported on utilization IBPs mimics organs, is, some groups revealed exhibited superiorities cryopreservation, while other showed detrimental effects. this perspective, we analyze possible reasons controversy predict future research directions design construction IBP inspired ice-binding be new CPAs after briefly introducing cryo-injuries challenges conventional organs.

Language: Английский

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Physiological Barriers and Strategies of Lipid‐Based Nanoparticles for Nucleic Acid Drug Delivery

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 4, 2023

Abstract Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic acid drug (NAD) delivery. Although their clinical applications have achieved success, NAD delivery efficiency and safety still unsatisfactory, which are, to a large extent, due existence of multi‐level physiological barriers in vivo. It is important elucidate interactions between these LBNPs, will guide more rational design efficient with low adverse effects facilitate broader therapeutics. This review describes obstacles challenges biological at systemic, organ, sub‐organ, cellular, subcellular levels. The strategies overcome comprehensively reviewed, mainly including physically/chemically engineering LBNPs directly modifying by auxiliary treatments. Then potentials successful translation preclinical studies into clinic discussed. In end, forward look on manipulating protein corona (PC) addressed, may pull off trick overcoming those significantly improve efficacy LBNP‐based NADs

Language: Английский

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Bioactive components and molecular mechanisms of Salvia miltiorrhiza Bunge in promoting blood circulation to remove blood stasis

Journal of Ethnopharmacology, Journal Year: 2023, Volume and Issue: 317, P. 116697 - 116697

Published: June 8, 2023

Language: Английский

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Role of CD93 in Health and Disease

Cells, Journal Year: 2023, Volume and Issue: 12(13), P. 1778 - 1778

Published: July 4, 2023

CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp), is a transmembrane glycoprotein encoded by gene located on 20p11.21 and composed of 652 amino acids. can be present in two forms: soluble (sCD93) membrane-bound (CD93). mainly expressed endothelial cells, where it plays key role promoting angiogenesis both physiology disease, such age-related macular degeneration tumor angiogenesis. In fact, highly tumor-associated vessels its presence correlates with poor prognosis, immunotherapy response, immune cell infiltration high tumor, node metastasis (TNM) stage many cancer types. also hematopoietic stem cytotrophoblast platelets i.e., monocytes, neutrophils, B cells natural killer (NK) cells. Accordingly, involved modulating important inflammatory-associated diseases including systemic sclerosis neuroinflammation. Finally, cardiovascular disease development progression. this article, we reviewed the current literature regarding angiogenesis, inflammation growth order to understand could potential therapeutic target modify outcome abovementioned pathologies.

Language: Английский

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Bacterial lipopolysaccharide-induced endothelial activation and dysfunction: a new predictive and therapeutic paradigm for sepsis

European journal of medical research, Journal Year: 2023, Volume and Issue: 28(1)

Published: Sept. 12, 2023

Abstract Background Lipopolysaccharide, a highly potent endotoxin responsible for severe sepsis, is the major constituent of outer membrane gram-negative bacteria. Endothelial cells participate in both innate and adaptive immune responses as first cell types to detect lipopolysaccharide or other foreign debris bloodstream. are able recognize presence LPS recruit specific adaptor proteins domains TLR4, thereby initiating an intracellular signaling cascade. However, binding endothelial induces activation even damage, manifested by expression proinflammatory cytokines adhesion molecules that lead sepsis. Main findings involved local systemic inflammation, activating immunity. Translocation into circulation causes endotoxemia. dysfunction, including exaggerated coagulopathy vascular leakage, may play central role dysregulated host response pathogenesis By discussing many strategies used treat this review attempts provide overview how ever more complex syndrome sepsis potential development novel therapeutics. Conclusions To reduce patient morbidity mortality, preservation function would be management Graphical

Language: Английский

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