More than Just a Monolayer: the Multifaceted Role of Endothelial Cells in the Pathophysiology of Atherosclerosis DOI Creative Commons
Marion Mußbacher, Klaudia Schossleitner, Julia B. Kral‐Pointner

et al.

Current Atherosclerosis Reports, Journal Year: 2022, Volume and Issue: 24(6), P. 483 - 492

Published: April 11, 2022

Abstract Purpose of the Review In this review, we summarize current insights into versatile roles endothelial cells in atherogenesis. Recent Findings The vascular endothelium represents first barrier that prevents entry lipoproteins and leukocytes vessel wall, thereby controlling two key events pathogenesis atherosclerosis. Disturbance homeostasis increases permeability, inflammation, cellular trans-differentiation, which not only promotes build-up atherosclerotic plaques but is also involved life-threatening thromboembolic complications such as plaque rupture erosion. focus on recent findings lipoprotein transport, transitions, function. Summary By using cutting-edge technologies single-cell sequencing, epigenetics, cell fate mapping, novel regulatory mechanisms phenotypes have been discovered, challenged established concepts activation, led to a different view disease.

Language: Английский

Integrin-Dependent Cell–Matrix Adhesion in Endothelial Health and Disease DOI Creative Commons
Jurjan Aman, Coert Margadant

Circulation Research, Journal Year: 2023, Volume and Issue: 132(3), P. 355 - 378

Published: Feb. 2, 2023

The endothelium is a dynamic, semipermeable layer lining all blood vessels, regulating vessel formation and barrier function. Proper composition function of the endothelial are required for fluid homeostasis, clinical conditions characterized by disruption associated with severe morbidity high mortality rates. Endothelial properties regulated cell-cell junctions intracellular signaling pathways governing cytoskeleton, but recent insights indicate an increasingly important role integrin-mediated cell-matrix adhesion in regulation. Here, we discuss diseases disruption, provide overview complexes pathways, their crosstalk junctions, other receptors. We further present into adhesions developing mature/adult various vascular beds, how dynamic regulation turnover regulates (patho)physiological like angiogenesis, inflammation response to hemodynamic stress. Finally, as leak still lack direct treatment, focus on understanding may novel targets current translational challenges future perspectives.

Language: Английский

Citations

45
Therapeutic targeting of cellular senescence in diabetic macular edema: preclinical and phase 1 trial results DOI
Sergio Crespo‐Garcia, Frédérik Fournier, Roberto Diaz-Marin

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(2), P. 443 - 454

Published: Feb. 1, 2024

Language: Английский

Citations

37
A systems view of the vascular endothelium in health and disease DOI Creative Commons
Hellmut G. Augustin, Gou Young Koh

Cell, Journal Year: 2024, Volume and Issue: 187(18), P. 4833 - 4858

Published: Sept. 1, 2024

Language: Английский

Citations

32
The Definition, Acronyms, Nomenclature, and Classification of Angioedema: AAAAI, ACAAI, ACARE, and APAACI DANCE Consensus DOI
Avner Reshef,

Thomas Buttgereit,

Stephen D. Betschel

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2024, Volume and Issue: 154(2), P. 398 - 411.e1

Published: April 25, 2024

Language: Английский

Citations

30
Unravelling the in vivo dynamics of liposomes: Insights into biodistribution and cellular membrane interactions DOI
Sharanya Paramshetti, Mohit Angolkar, Sirajunisa Talath

et al.

Life Sciences, Journal Year: 2024, Volume and Issue: 346, P. 122616 - 122616

Published: April 8, 2024

Language: Английский

Citations

22
Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications DOI Creative Commons
Alfredo Caturano,

Maria Rocco,

Giuseppina Tagliaferri

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 72 - 72

Published: Jan. 9, 2025

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly increases the risk of cardiovascular disease, which leading cause morbidity and mortality among diabetic patients. A central pathophysiological mechanism linking T2DM to complications oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production body’s antioxidant defenses. Hyperglycemia in promotes stress through various pathways, including formation advanced glycation end products, activation protein kinase C, mitochondrial dysfunction, polyol pathway. These processes enhance ROS generation, endothelial vascular inflammation, exacerbation damage. Additionally, disrupts nitric oxide signaling, impairing vasodilation promoting vasoconstriction, contributes complications. This review explores molecular mechanisms by pathogenesis disease T2DM. It also examines potential lifestyle modifications, such dietary changes physical activity, reducing mitigating risks this high-risk population. Understanding these critical for developing targeted therapeutic strategies improve outcomes

Language: Английский

Citations

8
Advances in Drug Targeting, Drug Delivery, and Nanotechnology Applications: Therapeutic Significance in Cancer Treatment DOI Creative Commons
Fatih Çiftçi, Ali Can Özarslan, İmran Cagri Kantarci

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 121 - 121

Published: Jan. 16, 2025

In the 21st century, thanks to advances in biotechnology and developing pharmaceutical technology, significant progress is being made effective drug design. Drug targeting aims ensure that acts only pathological area; it defined as ability accumulate selectively quantitatively target tissue or organ, regardless of chemical structure active substance method administration. With targeting, conventional, biotechnological gene-derived drugs body’s organs, tissues, cells can be transported specific regions. These systems serve carriers regulate timing release. Despite having many advantageous features, these have limitations thoroughly treating complex diseases such cancer. Therefore, combining with nanoparticle technologies imperative treat cancer at both local systemic levels effectively. The nanocarrier-based delivery involves encapsulating target-specific molecules into polymeric vesicular systems. Various (DDS) were investigated discussed this review article. first part passive systems, hydrogels, thermoplastics, microdevices transdermal-based second carrier nanobiotechnology (carbon nanotubes, nanoparticles, coated, pegylated, solid lipid nanoparticles smart nanogels). third part, advantages discussed, finally, market research commercial used nanotechnological approaches was included.

Language: Английский

Citations

5
Probiotics in inflammatory bowel disease: microbial modulation and therapeutic prospects DOI
Omar P. Vallejos, Susan M. Bueno, Alexis M. Kalergis

et al.

Trends in Molecular Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

4
Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression DOI Creative Commons
Yi‐Cheng Zhu,

Jiaoshun Chen,

Chen Chen

et al.

Biomarker Research, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 23, 2025

The tumor microenvironment functions as a dynamic and intricate ecosystem, comprising diverse array of cellular non-cellular components that precisely orchestrate pivotal behaviors, including invasion, metastasis, drug resistance. While unraveling the interplay between behaviors represents tremendous challenge, recent research illuminates crucial biological phenomenon known mechanotransduction. Within microenvironment, mechanical cues like tensile stress, shear stiffness play role by activating mechanosensitive effectors such PIEZO proteins, integrins, Yes-associated protein. This activation initiates cascades intrinsic signaling pathways, effectively linking physical properties tissues to their physiological pathophysiological processes morphogenesis, regeneration, immunity. mechanistic insight offers novel perspective on how within impact behaviors. intricacies are yet be fully elucidated, it exhibits distinct attributes from non-malignant tissues, elevated solid stresses, interstitial hypertension, augmented matrix stiffness, enhanced viscoelasticity. These traits exert notable influences progression treatment responses, enriching our comprehension multifaceted nature microenvironment. Through this innovative review, we aim provide new lens decipher contexts, broadening knowledge these factors promote or inhibit thus offering valuable insights identify potential targets for anti-tumor strategies.

Language: Английский

Citations

3
Uremic Toxins: An Alarming Danger Concerning the Cardiovascular System DOI Creative Commons
Carlos Alexandre Falconi, Carolina Victória Cruz Junho, Fernanda Fogaça-Ruiz

et al.

Frontiers in Physiology, Journal Year: 2021, Volume and Issue: 12

Published: May 14, 2021

The kidneys and heart share functions with the common goal of maintaining homeostasis. When kidney injury occurs, many compounds, so-called "uremic retention solutes" or toxins," accumulate in circulation targeting other tissues. accumulation uremic toxins such as

Language: Английский

Citations

92