Biosystems, Journal Year: 2023, Volume and Issue: 235, P. 105107 - 105107
Published: Dec. 19, 2023
Language: Английский
Communications Biology, Journal Year: 2024, Volume and Issue: 7(1)
Published: March 28, 2024
Abstract A defining feature of biology is the use a multiscale architecture, ranging from molecular networks to cells, tissues, organs, whole bodies, and swarms. Crucially however, not only nested structurally, but also functionally: each level able solve problems in distinct problem spaces, such as physiological, morphological, behavioral state space. Percolating adaptive functionality one competent subunits higher functional organization requires collective dynamics: multiple components must work together achieve specific outcomes. Here we overview number biological examples at different scales which highlight ability cellular material make decisions that implement cooperation toward homeodynamic endpoints, intelligence by solving cell, tissue, whole-organism levels. We explore hypothesis province groups animals, an important symmetry exists between science swarms competencies cells other systems scales. then briefly outline implications this approach, possible impact tools field diverse for regenerative medicine synthetic bioengineering.
Language: Английский
Citations
33
Entropy, Journal Year: 2024, Volume and Issue: 26(3), P. 194 - 194
Published: Feb. 24, 2024
The ideas of self-observation and self-representation, the concomitant idea self-control, pervade both cognitive life sciences, arising in domains as diverse immunology robotics. Here, we ask a very general way whether, to what extent, these make sense. Using generic model physical interactions, prove theorem several corollaries that severely restrict applicable notions self-observation, self-control. We show, particular, adding observational, representational, or control capabilities meta-level component system cannot, even principle, lead complete representation whole. conclude self-representation can at best be heuristic, self models general, empirically tested by systems implement them.
Language: Английский
Citations
11
Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(5), P. 391 - 394
Published: April 18, 2024
Electroceuticals have evolved beyond devices manipulating neuronal signaling for symptomatic treatment, becoming more precise and disease modulating expanding the nervous system. These advancements promise transformative applications in arthritis, cancer tissue regeneration, more. Here, we discuss these recent advances offer insights future research.
Language: Английский
Citations
9
Entropy, Journal Year: 2024, Volume and Issue: 26(6), P. 481 - 481
Published: May 31, 2024
Many studies on memory emphasize the material substrate and mechanisms by which data can be stored reliably read out. Here, I focus complementary aspects: need for agents to dynamically reinterpret modify memories suit their ever-changing selves environment. Using examples from developmental biology, evolution, synthetic bioengineering, in addition neuroscience, propose that a perspective as preserving salience, not fidelity, is applicable many phenomena scales cells societies. Continuous commitment creative, adaptive confabulation, molecular behavioral levels, answer persistence paradox it applies individuals whole lineages. also speculate substrate-independent, processual view of life mind suggests memories, patterns excitable medium cognitive systems, could seen active sense-making process. explore diverse set embodied perspectives—nested who interpret each other’s own past messages actions best they (polycomputation). This synthesis unifying symmetries across disciplines, relevance research programs Diverse Intelligence engineering novel minds.
Language: Английский
Citations
9
Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 52, P. 256 - 273
Published: Jan. 18, 2025
Language: Английский
Citations
1
Communicative & Integrative Biology, Journal Year: 2025, Volume and Issue: 18(1)
Published: Feb. 17, 2025
We argue here that the Origin of Life (OOL) problem is not just a chemistry but also, and primarily, cognitive science problem. When interpreted through lens Conway-Kochen theorem Free Energy Principle, contemporary physics characterizes all complex dynamical systems persist time as Bayesian agents. If persistent are to some – perhaps only minimal extent cognitive, alive, or living subset systems? no bright line can be drawn, we re-assess, from this perspective, Fermi paradox Drake equation. conclude improving our abilities recognize communicate with diverse intelligences in embodiments, whether based on familiar biochemistry not, will either resolve obviate OOL
Language: Английский
Citations
1
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(9), P. 2180 - 2202
Published: Jan. 1, 2024
Electrical activity underpins all life, but is most familiar in the nervous system, where long range electrical signalling essential for function. When this lost (
Language: Английский
Citations
7
Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 731, P. 150396 - 150396
Published: July 14, 2024
Individual cells have numerous competencies in physiological and metabolic spaces. However, multicellular collectives can reliably navigate anatomical morphospace towards much larger, reliable endpoints. Understanding the robustness control properties of this process is critical for evolutionary developmental biology, bioengineering, regenerative medicine. One mechanism that has been proposed enabling individual to coordinate toward specific morphological outcomes sharing stress (where a parameter reflects current amount error context homeostatic loop). Here, we construct analyze multiscale agent-based model morphogenesis which quantitatively examine impact on ability reach target morphology. We found improves morphogenetic efficiency collectives; populations with reached targets faster. Moreover, influenced future fate distant multi-cellular collective, enhancing cells' movement their radius influence, consistent hypothesis works increase cohesiveness collectives. During development, goal states could not be inferred from observation states, revealing limitations knowledge goals by an extern observer outside system itself. Taken together, our analyses support important role natural engineered systems seek robust large-scale behaviors emerge activity competent components.
Language: Английский
Citations
6
Trends in Endocrinology and Metabolism, Journal Year: 2024, Volume and Issue: 35(10), P. 884 - 901
Published: Oct. 1, 2024
Language: Английский
Citations
5
eLife, Journal Year: 2025, Volume and Issue: 13
Published: Jan. 13, 2025
Many applications in biomedicine and synthetic bioengineering rely on understanding, mapping, predicting, controlling the complex behavior of chemical genetic networks. The emerging field diverse intelligence investigates problem-solving capacities unconventional agents. However, few quantitative tools exist for exploring competencies non-conventional systems. Here, we view gene regulatory networks (GRNs) as agents navigating a problem space develop automated to map robust goal states GRNs can reach despite perturbations. Our contributions include: (1) Adapting curiosity-driven exploration algorithms from AI discover range reachable GRNs, (2) Proposing empirical tests inspired by behaviorist approaches assess their navigation competencies. data shows that models inferred biological wide spectrum steady states, exhibiting various physiological network dynamics without requiring structural changes properties or connectivity. We also explore applicability these ‘behavioral catalogs’ comparing evolved across networks, designing drug interventions biomedical contexts bioengineering. These emphasis behavior-shaping open new paths efficiently For interactive version this paper, please visit https://developmentalsystems.org/curious-exploration-of-grn-competencies .
Language: Английский
Citations
0