Clinical and Molecular Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: Aug. 5, 2024
Language: Английский
Nutrients, Journal Year: 2024, Volume and Issue: 16(15), P. 2454 - 2454
Published: July 28, 2024
Postbiotics could exert different metabolic activities in animal models of non-alcoholic fatty liver disease (NAFLD) and humans affected by syndrome. This is a randomized, double-blind, placebo-controlled, parallel-group clinical trial that enrolled sample 50 Caucasian healthy individuals with NAFLD, defined as steatosis, After 4-week run-in, the were randomized to take food for special medical purposes functional release, one tablet day, containing calcium butyrate (500 mg/tablet), zinc gluconate (zinc 5 vitamin D3 IU/tablet), or an identical placebo 3 months. Liver parameters measured at baseline end study. No subject experienced any adverse events during trial. In both groups, significant decrease total cholesterol (TC) triglycerides (TG) plasma levels was observed randomization visit vs. pre-run-in (
Language: Английский
Citations
9
European Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
The integration of sex and gender in medical research clinical practice is increasingly recognized as a cornerstone for achieving equitable health outcomes. Biological influence the manifestation, progression, treatment response numerous diseases. influences disease outcomes through genetic, hormonal, physiological factors, while impacts them via identity, societal roles behaviors. Historically, has focused predominantly on male body, leading to diagnostic therapeutic gaps women gender-diverse populations. In particular, remain underrepresented trials, suboptimal strategies addition, many conditions, such cardiovascular, metabolic neurological diseases, sex-specific variations risk factors presentation are prominent. present review discusses critical importance distinguishing between preclinical research, necessity incorporating these variables across all stages from study design analysis reporting studies trials. By distinct but interacting variables, we propose framework advance equity foster personalized, inclusive healthcare. This approach will promote development gender-sensitive guidelines, enhance accuracy tools, ultimately contribute improved individuals, regardless their or identity.
Language: Английский
Citations
1
Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 156190 - 156190
Published: March 1, 2025
Language: Английский
Citations
1
Liver International, Journal Year: 2025, Volume and Issue: 45(4)
Published: March 12, 2025
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has become the most common chronic globally. MASLD is a multisystem where metabolic dysfunction plays key role in development of and its relevant liver‐related morbidities extrahepatic complications, such as cardiovascular disease, kidney certain types cancers. Among least examined MASLD‐related an ever‐increasing number observational studies have reported positive association between risk serious bacterial infections (SBI) requiring hospital admission. This remained significant those statistical analysis was adjusted for age, sex, ethnicity, obesity, type 2 diabetes other comorbidities. Notably, incidence rates SBI were further increased with more advanced MASLD, especially patients cirrhosis, also observed some acute viral infections, including SARS‐CoV‐2 infection, leading to severe COVID‐19. In this narrative review article, we provide overview literature on (a) recent epidemiological data linking non‐bacterial admission, (b) putative underlying mechanisms through which may increase susceptibility both directly immune associated cirrhosis portal hypertension, (c) practical clinical implications growing global population MASLD.
Language: Английский
Citations
1
Nature Reviews Gastroenterology & Hepatology, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 5, 2024
Language: Английский
Citations
6
Liver International, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 11, 2024
Abstract Metabolic dysfunction–associated steatotic liver disease (MASLD, previously termed NAFLD, nonalcoholic fatty disease) is a complex multifactorial showing generally higher prevalence and severity in men than women. With respect to women, are also more prone develop metabolic steatohepatitis, fibrosis liver‐related complications. Several genetic, hormonal, environmental lifestyle factors may contribute sex differences MASLD development, progression outcomes. However, after menopause, the sex‐specific of shows an opposite trend between pointing relevance oestrogen signalling sexual dimorphism MASLD. The patatin‐like phospholipase domain‐containing protein 3 ( PNPLA3 ) gene, that encodes triacylglycerol lipase plays crucial role lipid metabolism, has emerged as key player pathogenesis MASLD, with I148M variant being strongly associated increased fat content severity. Recent advances indicate carrying can be risk factor for especially To elucidate molecular mechanisms underlying development several vitro, ex vivo models have been developed.
Language: Английский
Citations
5
iScience, Journal Year: 2025, Volume and Issue: 28(2), P. 111863 - 111863
Published: Jan. 21, 2025
Language: Английский
Citations
0
Metabolism Open, Journal Year: 2025, Volume and Issue: unknown, P. 100351 - 100351
Published: Jan. 1, 2025
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2882 - 2882
Published: March 22, 2025
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a condition wherein excessive fat accumulates in the liver, leading to inflammation and potential damage. In this narrative review, we evaluate tissue microbiota, how they arise their constituent microbes, role of intestinal hepatic microbiota MASLD. The history bacteriophages (phages) occurrence part causation MASLD, conversely, "phage therapy" for antibiotic resistance, obesity, are all described. metabolism bile acids dietary tryptophan histidine defined, together with impacts individual metabolites on MASLD pathogenesis. Both periodontitis dysbiosis may cause microorganisms involved these processes discussed. Novel treatment opportunities involving exist include fecal transplantation, probiotics, prebiotics, synbiotics, supplements, intermittent fasting, phages or holins endolysins. Although FDA yet approve phage therapy clinical use, there multiple FDA-approved trials, represent new horizon future
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: March 27, 2025
common cause of chronic liver disease. A meta-analysis published in 2016 reported the 19 global prevalence NAFLD is 25% and it was leading disease 20 then [1]. recent systematic review showed burden MASLD has increased to 21 an estimate about 38% [2]. In past 3 decades steadily 22 by 50% continues grow [3]. The overall men 23 (39.7%) significantly higher than women (25.6%). estimates incidence rates 24 were 46.9 cases per 1000 person-year, with 70.8 person-year
Language: Английский
Citations
0