Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Feb. 16, 2023
Metabolic
reprogramming
is
one
of
fourteen
hallmarks
tumor
cells,
among
which
aerobic
glycolysis,
often
known
as
the
“Warburg
effect,”
essential
to
fast
proliferation
and
aggressive
metastasis
cells.
Lactate,
on
other
hand,
a
ubiquitous
molecule
in
microenvironment
(TME),
generated
primarily
by
cells
undergoing
glycolysis.
To
prevent
intracellular
acidification,
malignant
remove
lactate
along
with
H
+
,
yet
acidification
TME
inevitable.
Not
only
does
highly
concentrated
within
serve
substrate
supply
energy
but
it
also
works
signal
activate
multiple
pathways
that
enhance
invasion,
intratumoral
angiogenesis,
well
immune
escape.
In
this
review,
we
aim
discuss
latest
findings
metabolism
particularly
capacity
extracellular
influence
microenvironment.
addition,
examine
current
treatment
techniques
employing
existing
medications
target
interfere
generation
transport
cancer
therapy.
New
research
shows
targeting
metabolism,
lactate-regulated
action
are
viable
therapy
strategies.
Chemical Science,
Journal Year:
2022,
Volume and Issue:
13(8), P. 2202 - 2217
Published: Jan. 1, 2022
This
review
summarizes
the
current
progress
of
redox
dyshomeostasis
(RDH)
strategy
for
tumor
therapy.
makes
cells
more
sensitive
to
therapy
patterns
through
using
nanomaterials
disrupt
homeostasis.
Pharmacological Reports,
Journal Year:
2023,
Volume and Issue:
75(4), P. 876 - 890
Published: June 19, 2023
Abstract
Although
Warburg's
discovery
of
intensive
glucose
uptake
by
tumors,
followed
lactate
fermentation
in
oxygen
presence
was
made
a
century
ago,
it
is
still
an
area
intense
research
and
development
new
hypotheses
that,
layer
layer,
unravel
the
complexities
neoplastic
transformation.
This
seemingly
simple
metabolic
reprogramming
cancer
cells
reveals
intriguing,
multi-faceted
nature
that
may
link
various
phenomena
including
cell
signaling,
proliferation,
ROS
generation,
energy
supply,
macromolecules
synthesis/biosynthetic
precursor
immunosuppression,
or
cooperation
cancerous
with
cancer-associated
fibroblasts
(CAFs),
known
as
reversed
Warburg
effect.
According
to
current
perception
causes
consequences
effect,
PI3K/Akt/mTOR
are
main
signaling
pathways
concert
transcription
factors
HIF-1,
p53,
c-Myc,
modulate
activity/expression
key
regulatory
enzymes,
PKM2,
PDK1
tune
most
optimal
setting
for
cell.
turn
secures
adequate
levels
biosynthetic
precursors,
NADPH,
NAD
+
,
rapid
ATP
production
meet
increased
demands
intensively
proliferating
tumor
cells.
The
end-product
“aerobic
glycolysis”,
lactate,
oncometabolite,
provide
fuel
neighboring
cells,
facilitate
metastasis
immunosuppression
together
enabling
progression.
importance
possible
applicability
presented
issue
best
illustrated
numerous
trials
agents
targeting
constituting
promising
strategy
future
anti-cancer
regimens.
In
this
review,
we
present
aspects
multifactorial
phenomenon,
depicting
mechanisms
benefits
behind
also
pointing
selected
field
anticancer
therapy.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(6), P. 3142 - 3142
Published: March 8, 2024
The
Warburg
effect,
characterized
by
the
preferential
conversion
of
glucose
to
lactate
even
in
presence
oxygen
and
functional
mitochondria,
is
a
prominent
metabolic
hallmark
cancer
cells
has
emerged
as
promising
therapeutic
target
for
therapy.
Elevated
levels
acidic
pH
within
tumor
microenvironment
(TME)
resulting
from
glycolytic
profoundly
impact
various
cellular
populations,
including
macrophage
reprogramming
impairment
T-cell
functionality.
Altogether,
effect
been
shown
promote
progression
immunosuppression
through
multiple
mechanisms.
This
review
provides
an
overview
current
understanding
its
implications.
We
summarize
recent
pharmacological
strategies
aimed
at
targeting
enzymes,
highlighting
challenges
encountered
achieving
efficacy.
Additionally,
we
examine
utility
early
diagnostic
tool.
Finally,
discuss
multifaceted
roles
TME,
emphasizing
potential
disrupt
interactions
between
immune
cells,
thereby
enhancing
anti-tumor
immunity.
Frontiers in Nutrition,
Journal Year:
2023,
Volume and Issue:
10
Published: Feb. 16, 2023
Metabolic
reprogramming
is
one
of
fourteen
hallmarks
tumor
cells,
among
which
aerobic
glycolysis,
often
known
as
the
“Warburg
effect,”
essential
to
fast
proliferation
and
aggressive
metastasis
cells.
Lactate,
on
other
hand,
a
ubiquitous
molecule
in
microenvironment
(TME),
generated
primarily
by
cells
undergoing
glycolysis.
To
prevent
intracellular
acidification,
malignant
remove
lactate
along
with
H
+
,
yet
acidification
TME
inevitable.
Not
only
does
highly
concentrated
within
serve
substrate
supply
energy
but
it
also
works
signal
activate
multiple
pathways
that
enhance
invasion,
intratumoral
angiogenesis,
well
immune
escape.
In
this
review,
we
aim
discuss
latest
findings
metabolism
particularly
capacity
extracellular
influence
microenvironment.
addition,
examine
current
treatment
techniques
employing
existing
medications
target
interfere
generation
transport
cancer
therapy.
New
research
shows
targeting
metabolism,
lactate-regulated
action
are
viable
therapy
strategies.
