Food Bioscience, Journal Year: 2024, Volume and Issue: unknown, P. 105722 - 105722
Published: Dec. 1, 2024
Language: Английский
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: March 4, 2025
Language: Английский
Citations
1
Frontiers in Plant Science, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 6, 2024
Stachydrine, also known as proline betaine, is a prominent constituent of traditional Chinese herb Leonurus japonicus , renowned for its significant pharmacological effects. Widely distributed in plants like and Citrus aurantium well various bacteria, stachydrine serves pivotal physiological functions across animal, plant, bacterial kingdoms. This review aims to summarizes diverse roles mechanisms addressing cardiovascular cerebrovascular diseases, neuroprotection, anticancer activity, uterine regulation, anti-inflammatory response, obesity management, respiratory ailments. Notably, exhibits cardioprotective effects via multiple pathways encompassing anti-inflammatory, antioxidant, anti-apoptotic, modulation calcium handling functions. Furthermore, anti-cancer properties inhibit proliferation migration numerous cancer cell types. With bi-directional regulatory effect on function, holds promise obstetrics gynecology-related disorders. In plants, secondary metabolite, contributing osmotic pressure nitrogen fixation, pest resistance, stress response. Similarly, it plays crucial osmoprotective role, facilitating adaptation high environments. addresses ongoing research the anabolic metabolism stachydrine. While biosynthetic pathway remains incompletely understood, metabolic well-established. A deeper understanding biosynthesis significance elucidating mechanism action, advancing study plant metabolism, enhancing drug quality control, fostering new development endeavors.
Language: Английский
Citations
8
Scientific Data, Journal Year: 2024, Volume and Issue: 11(1)
Published: Jan. 9, 2024
Chinese motherwort (Leonurus japonicus), a member of Lamiaceae family, is commonly used medicinal herb for treating obstetrical and gynecological diseases, producing over 280 officinal natural products. Due to limited genomic resources, little progress has been made in deciphering the biosynthetic pathway valuable products L. japonicus. Here, we de novo assembled japonicus genome using high-coverage ONT long reads Hi-C reads. The chromosome-level assembly contained ten chromosomes representing 99.29% 489.34 Mb sequence with contig scaffold N50 7.27 50.86 Mb, respectively. Genome validations revealed BUSCO LAI score 99.2% 21.99, respectively, suggesting high quality assembly. Using transcriptomic data from various tissues, 22,531 protein-coding genes were annotated. Phylogenomic analysis 13 angiosperm plants suggested had 58 expanded gene families functionally enriched specialized metabolism such as diterpenoid biosynthesis. assembly, annotation, sequencing provide resources elucidation pathways behind pharmaceutical applications
Language: Английский
Citations
5
Current Opinion in Plant Biology, Journal Year: 2024, Volume and Issue: 81, P. 102576 - 102576
Published: June 14, 2024
Language: Английский
Citations
4
Industrial Crops and Products, Journal Year: 2024, Volume and Issue: 218, P. 119017 - 119017
Published: June 18, 2024
Language: Английский
Citations
4
BMC Biology, Journal Year: 2025, Volume and Issue: 23(1)
Published: March 20, 2025
The relationship between gene family expansion and the resulting changes in plant phenotypes has shown remarkable complexity during evolution. contributed to diversity phenotypes, specifically metabolites through neo-functionalization sub-functionalization. However, negative regulatory effects associated with remain poorly understood. Here, we present chromosome-scale genomes of Tinospora crispa sinensis. Comparative genomic analyses demonstrated conserved chromosomal evolution within Menispermaceae family. KEGG analysis revealed a significant enrichment genes related terpenoid biosynthesis T. exhibited higher abundance terpenoids compared Detailed encoding 1-hydroxy-2-methyl 2-(E)-butenyl 4-diphosphate synthase (HDS), key enzyme 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway TsiHDS4 retained ancestral function converting methylerythritol cyclic diphosphate (MEcPP) (E)-4-hydroxy-3-methylbut-2-enyl (HMBPP). noncanonical CDS-derived small peptide TsiHDS5 was interact TsiHDS4, inhibiting its catalytic activity. This interaction reduced levels HMBPP isopentenyl pyrophosphate (IPP), which represent substrates for downstream biosynthesis. These findings offer clues decipher variations MEP sinensis form basis further detailed research on regulation expanded genes.
Language: Английский
Citations
0
BIO Web of Conferences, Journal Year: 2025, Volume and Issue: 173, P. 01006 - 01006
Published: Jan. 1, 2025
This study investigates the genetic diversity and evolutionary relationships within genus Leonurus , focusing on species found in Uzbekistan. For first time region, molecular tools were applied to analyze using Internal Transcribed Spacer (ITS) markers. Samples collected from Tashkent region sequenced, additional ITS data 21 representatives of Lamiaceae family retrieved GenBank. The sequences aligned CLUSTALW tool, refined with Snap Gene, analyzed Maximum Likelihood (ML) method Kimura 2-parameter (K2P) model IQ-TREE program. resulting phylogenetic tree revealed among closely related genera like Lagochilus Paraphlomis . High bootstrap values (99.9%–100%) confirmed reliability these findings. sp. UZB clustered glaucescens turkestanicus suggesting a shared origin. Close proximity was observed between cardiaca while sibiricus more genetically distant, likely due ecological or geographical isolation. Additionally, analysis highlighted significant differences indicating early divergence. These findings provide valuable insights into structure history species, emphasizing need preserve similar together for long-term population stability. research also underscores practical importance such studies biodiversity conservation adaptive management. Future work should expand genome-level analyses explore environmental factors influencing variation populations enhance efforts sustainable use plant resources.
Language: Английский
Citations
0
Functional & Integrative Genomics, Journal Year: 2024, Volume and Issue: 24(6)
Published: Nov. 4, 2024
Language: Английский
Citations
3
The Plant Journal, Journal Year: 2025, Volume and Issue: 121(2)
Published: Jan. 1, 2025
Basil, Ocimum basilicum L., is a widely cultivated aromatic herb, prized for its culinary and medicinal uses, predominantly owing to unique aroma, primarily determined by eugenol Genovese cultivars or methyl chavicol Thai cultivars. To date, comprehensive basil reference genome has been lacking, with only fragmented draft available. fill this gap, we employed PacBio HiFi Hi-C sequencing construct homeolog-phased chromosome-level basil. The tetraploid was assembled into 26 pseudomolecules further categorized subgenomes. High levels of synteny were observed between the two subgenomes but comparisons Salvia rosmarinus show collinearity quickly breaks down in near relatives. We utilized bi-parental population derived from × cross map quantitative trait loci (QTL) aroma chemotype. discovered single QTL governing eugenol/methyl ratio, which encompassed genomic region 95 genes, including 15 genes encoding shikimate O-hydroxycinnamoyltransferase (HCT/CST) enzyme. Of them, ObHCT1 exhibited significantly higher expression cultivar showed trichome-specific expression. functionally confirmed as genuine HCT enzyme using an vitro assay. high-quality, contiguous now publicly accessible at BasilBase, valuable resource scientific community. Combined insights cell-type-specific gene expression, it promises elucidate specialized metabolite biosynthesis pathways cellular level.
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 18, 2025
Language: Английский
Citations
0