Mini-Reviews in Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
20(4), P. 415 - 435
Published: June 7, 2022
Abstract:
Functionalized
polysubstituted
quinoxalines
have
been
widely
reported
to
possess
appealing
biological
activities
of
great
pharmaceutical
importance
which
drew
researchers
into
exploring
promising
synthetical
protocols.
On
top
that,
prospects
on
green
chemistry
are
driving
research
paradigms
more
cost-effective,
facile,
environmental-friendly,
sustainable,
and
scalable
approaches.
This
paper
reviews
the
synthesis
methods
quinoxaline
derivatives
using
recyclable
heterogeneous
catalysts,
solvents
energy-mediated
that
extensively
studied
published
since
2010
offer
an
insight
ongoing
greener
trend
in
scientific
field.
Ultrasonics Sonochemistry,
Journal Year:
2021,
Volume and Issue:
78, P. 105704 - 105704
Published: Aug. 5, 2021
Ultrasound
is
an
essential
technique
to
improve
organic
synthesis
from
the
point
of
view
green
chemistry,
as
it
can
promote
better
yields
and
selectivities,
in
addition
shorter
reaction
times
when
compared
conventional
methods.
Heterogeneous
catalysis
another
pillar
sustainable
chemistry
being
recycling
reuse
catalysts
one
its
great
advantage.
In
other
hand,
multicomponent
reactions
provide
structurally
diverse
compounds,
a
one-pot
fashion,
without
isolation
purification
intermediates.
Thus,
combination
these
protocols
has
proved
be
powerful
tool
obtain
biologically
active
compounds
with
lower
costs,
time
energy
consumption.
Herein,
we
comprehensive
overview
advances
on
methods
that
have
been
reported
over
past
ten
years
focus
ultrasound-assisted
under
heterogeneous
catalysis.
particular,
present
pharmacologically
important
N-
O-heterocyclic
considering
their
synthetic
using
solvents,
catalyst
recycling.
Ultrasonics Sonochemistry,
Journal Year:
2023,
Volume and Issue:
102, P. 106741 - 106741
Published: Dec. 23, 2023
Ultrasonic
irradiation
serves
as
a
vigorous
and
environmentally
sustainable
approach
for
augmenting
multicomponent
reactions
(MCRs),
offering
benefits
such
thermal
enhancement,
agitation,
activation,
among
others.
Malononitrile
emerges
versatile
reagent
in
this
context,
participating
myriad
of
MCRs
to
produce
structurally
diverse
heterocyclic
frameworks.
This
review
encapsulates
the
critical
role
malononitrile
sonochemical
synthesis
these
structures.
The
paper
further
delves
into
biochemical
pharmacological
implications
heterocycles,
elucidating
their
reaction
mechanisms
well
delineating
method's
scope
limitations.
We
furnish
an
overview
merits
challenges
inherent
synthetic
offer
insights
potential
avenues
future
research.
Scientific Reports,
Journal Year:
2021,
Volume and Issue:
11(1)
Published: June 7, 2021
In
an
attempt
to
find
novel,
potent
α-glucosidase
inhibitors,
a
library
of
poly-substituted
3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines
3a-ag
have
been
synthesized
through
heating
mixture
2-aminobenzimidazoles
1
and
α-azidochalcone
2
under
the
mild
conditions.
This
efficient,
facile
protocol
has
resulted
into
desirable
compounds
with
wide
substrate
scope
in
good
excellent
yields.
Afterwards,
their
inhibitory
activities
against
yeast
enzyme
were
investigated.
Showing
IC
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(5), P. 2750 - 2762
Published: Jan. 1, 2024
Temperature-driven
C–C,
C–N,
and
CC
bond
development
yields
3-hydroxy-3-(3-methyl-5-oxo-2-thioxoimidazolidin-4-yl)oxindoles
(Z)-3-(3-methyl-5-oxo-2-thioxoimidazolidin-4-ylidene)indolin-2-one
in
a
one-pot
green
"on
water"
synthesis.
Arabian Journal of Chemistry,
Journal Year:
2021,
Volume and Issue:
15(1), P. 103544 - 103544
Published: Nov. 9, 2021
Ultrasound-assisted
multicomponent
reactions
in
water
are
great
implements
for
the
development
of
bioactive
compounds.
The
methodologies
synthesis
different
heterocyclic
molecules
have
acquired
enormous
attention.
Many
such
techniques
energy-intensive
and
associated
with
hazardous
chemicals,
solvents,
expensive
work-ups.
Low
yields
multi-step
schemes
generate
huge
organic
waste.
Hence,
researchers
thus
focussed
on
benign
eco-friendly
to
assemble
analogs
drug
molecules.
ultrasound-assisted
target
moieties
frequently
facilitates
higher
product
than
other
methodologies.
This
review
is
focused
ultrasound-aided
synthesizing
varied
nitrogen-,
oxygen-,
sulfur-containing
compounds
using
as
solvent.
advantages
limitations
respect
reaction
conditions
discussed.
evaluation
covered
literature
reports
from
2014
date.
Inorganic Chemistry,
Journal Year:
2021,
Volume and Issue:
60(9), P. 6446 - 6462
Published: April 21, 2021
Four
new
mononuclear/coordination
polymeric
(CP)
zinc(II)
complexes
(1–4)
of
ferrocenyl/pyridyl-functionalized
dithiocarbamate
ligands,
N-ferrocenylmethyl-N-butyl
(L1),
N-ferrocenylmethyl-N-ethylmorpholine
(L2),
N-ferrocenylmethyl-N-2-(diethylamino)ethylamine
(L3),
and
N-4-methoxybenzyl-N-3-methylpyridyl
(L4),
have
been
synthesized
characterized
by
elemental
analyses,
IR,
UV–vis,
1H
13C{1H}
NMR
spectroscopic
techniques.
The
solid-state
structures
1,
3,
4
determined
single-crystal
X-ray
crystallography
as
well
powder
diffraction.
Single-crystal
revealed
a
monomeric
structure
for
complex
1
but
1D
3
4.
In
all
complexes,
ligands
are
bonded
to
the
Zn(II)
metal
ion
in
S^S
chelating
mode,
CPs,
N
atoms
on
2-(diethylamino)ethylamine
3-pyridyl
functionalities
neighboring
molecules
also
centers,
leading
formation
either
discrete
tetrahedral
molecule
or
CP
centers
exhibited
square-pyramidal
octahedral
geometries.
supramolecular
these
sustained
via
C–H···π
(ZnCS2,
chelate;
4),
C–H···π,
H···H
interactions.
catalytic
performances
assessed
Knoevenagel
condensation
one-pot
multicomponent
reactions.
Catalysis
results
showed
that
acts
heterogeneous
bifunctional
catalyst
with
excellent
transformation
efficiency
at
low
loading.
