Innovative Ultrasound‐Assisted Synthesis of Isoxazolo[5,4‐b]Pyridines from Aryl Glyoxal, 5‐Aminoisoxazoles, and Malononitrile in Acetic Acid as a Solvent and Catalyst DOI
Abdolali Alizadeh, Seyed Ali Hosseini

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(46)

Published: Dec. 1, 2024

Abstract In this work, a novel strategy for the straightforward synthesis of isoxazolo[5,4‐ b ]pyridines from one‐pot reaction aryl glyoxal, 5‐aminoisoxazoles, and malononitrile under ultrasound (US) irradiation is described. reaction, acetic acid has dual role as solvent catalyst. The advantages include easy purification products, raw materials with access, short time, high efficiency, green conditions by utilizing an energy source using Lewis acid. achieved yields broad substrate scope, successfully producing twelve diverse derivatives. methodology capitalizes on benefits sonochemistry, which accelerates rates improves selectivity while minimizing waste. proposed mechanism involves series reactions including Knoevenagel condensation, Michael addition, subsequent cyclization processes. This approach not only streamlines complex heterocycles but also aligns environmentally friendly practices.

Language: Английский

Recent advances in microwave-assisted multicomponent synthesis of spiro heterocycles DOI Creative Commons
Ramin Javahershenas, Ata Makarem, Karel D. Klika

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(8), P. 5547 - 5565

Published: Jan. 1, 2024

Spiro heterocycle frameworks are a class of organic compounds that possesses unique structural features making them highly sought-after targets in drug discovery due to their diverse biological and pharmacological activities.

Language: Английский

Citations

25
Recent Advances in the Application of 2‐Aminobenzothiazole to the Multicomponent Synthesis of Heterocycles DOI Creative Commons
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi

et al.

ChemistryOpen, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 9, 2024

Abstract Heterocycles are a vital class of compounds in numerous fields, including drug discovery, agriculture, and materials science. Efficient methods for the synthesis heterocycles remain critical meeting demands these industries. Recent advances multicomponent reactions (MCRs) utilizing 2‐aminobenzothiazole (ABT) have shown promising results formation heterocycles. The versatility this context has enabled rapid efficient construction diverse heterocyclic structures. Various synthetic methodologies involving discussed, highlighting its importance as valuable building block complex potential applications discovery material science also explored. Overall, review provides comprehensive overview current state research field offers insights into future directions area study. We highlight ABT versatile sustainable starting via MCRs, with significant implications chemical industry.

Language: Английский

Citations

20
Recent Advances in the Multicomponent Synthesis of Heterocycles using Thiosemicarbazide DOI Open Access
Ramin Javahershenas, Jianlin Han, Mosstafa Kazemi

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(30)

Published: Aug. 6, 2024

Abstract This review provides an overview of the recent advances in synthesis diverse heterocyclic compounds using thiosemicarbazide as a key building block via multicomponent reactions. Thiosemicarbazide is versatile reagent that has gained significant attention organic due to its ability participate reactions for efficient and sustainable construction assembly novel bioactive molecules pharmaceuticals. discusses potential applications future directions this rapidly evolving area research. It valuable insights into innovative approaches heterocycles thiosemicarbazide, showcasing significance modern chemistry In summary, current state art, highlighting use reported between 2015 early 2024.

Language: Английский

Citations

18
Magnetically recoverable catalysts for efficient multicomponent synthesis of organosulfur compounds DOI Creative Commons
Fadhil Faez Sead, Vicky Jain, Anjan Kumar

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(5), P. 3928 - 3953

Published: Jan. 1, 2025

This review studies magnetically recoverable catalysts designed for the efficient multicomponent synthesis of organosulfur compounds. These enhance process by combining efficiency with environmental sustainability.

Language: Английский

Citations

5
Carbon nanotubes as heterogeneous catalysts for the multicomponent reaction synthesis of heterocycles DOI
Ramin Javahershenas,

Vadim A. Soloshonok,

Karel D. Klika

et al.

Carbon letters, Journal Year: 2024, Volume and Issue: 35(1), P. 75 - 105

Published: Oct. 5, 2024

Language: Английский

Citations

9
ZnFe2O4-SiO2@PC-Ni nanoparticles for one-pot, solvent-free synthesis of imidazo[1,2-a]pyridines by A3 coupling reactions under ultrasound conditions DOI
Fadhil Faez Sead, Vicky Jain,

Suhas Ballal

et al.

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101653 - 101653

Published: March 1, 2025

Language: Английский

Citations

1
Green Utilizing AlFeO3 Nanoparticles-Catalyzed for Sustainable Biginelli Synthesis of 3, 4-Dihydropyrimidin-2(1H)-thiones in Glycerol DOI
Fadhil Faez Sead, Vicky Jain, Anjan Kumar

et al.

Catalysis Surveys from Asia, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Language: Английский

Citations

1
Efficient Synthesis, Structural Characterization, Antibacterial Assessment, ADME-Tox Analysis, Molecular Docking and Molecular Dynamics Simulations of New Functionalized Isoxazoles DOI Creative Commons

Aziz Arzine,

Hanine Hadni, Khalid Boujdi

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(14), P. 3366 - 3366

Published: July 17, 2024

This work describes the synthesis, characterization, and in vitro silico evaluation of biological activity new functionalized isoxazole derivatives. The structures all compounds were analyzed by IR NMR spectroscopy. 4c 4f further confirmed single crystal X-ray their compositions unambiguously determined mass spectrometry (MS). antibacterial effect isoxazoles was assessed against Escherichia coli, Bacillus subtilis, Staphylococcusaureus bacterial strains. Isoxazole 4a showed significant E. coli B. subtilis compared to reference antibiotic drugs while 4d also exhibited some effects. molecular docking results indicate that synthesized exhibit strong interactions with target proteins. Specifically, displayed a better affinity for S. aureus, comparison drugs. dynamics simulations performed on strongly support stability ligand–receptor complex when interacting active sites proteins from subtilis. Lastly, Absorption, Distribution, Metabolism, Excretion Toxicity Analysis (ADME-Tox) reveal molecules have promising pharmacokinetic properties, suggesting favorable druglike properties potential therapeutic agents.

Language: Английский

Citations

7
Study on the kinetics and mechanism of ultrasonic-microwave synergistic enhancement for leaching indium from zinc oxide dust DOI

Shiju Li,

Haibei Wang, Wang Sheng-dong

et al.

Chemical Papers, Journal Year: 2024, Volume and Issue: 78(6), P. 3667 - 3685

Published: Feb. 17, 2024

Language: Английский

Citations

5
Synthesis of azepane-acridine heterocyclic adducts assisted by the catalytic influence of γ-Fe2O3@TiO2-Vitamin B1 and evaluation of their medicinal potential through in vitro antimicrobial, QSAR, and molecular docking studies DOI Creative Commons

Shweta Potdar,

Pratibha Sharma, Nikita Pal

et al.

Results in Chemistry, Journal Year: 2024, Volume and Issue: 7, P. 101448 - 101448

Published: Jan. 1, 2024

Present work elicits synthesis of novel azepane-acridines, assisted by titania-encapsulated γFe2O3 nanoparticles supported on Vitamin B1 (γFe2O3@TiO2-Vitamin B1) as a new magnetically recyclable heterogeneous nano-catalytic system. The reaction was accomplished using biocompatible PEG-200 (Polyethylene glycol) the solvent under ultrasonic irradiations. structure and morphology synthesized magnetic nano-catalyst ascertained based data obtained from powder X-ray diffraction (PXRD), field emission scanning electron microscopy (FE-SEM), energy-dispersive spectroscopy (EDAX), Fourier transform infrared (FT-IR), VSM (Vibrating-sample magnetometer) TGA, DTA DTG techniques. characteristic size prepared heterogenous is 34.62 nm. Also, structures all azepane-acridine heterocyclic scaffolds were corroborated through spectro-analytical data. These compounds found to have remarkable biological activity profile against bacterium S.aureus with IC50 values ranging 1.41 2.75 µg/mL. Further, these in-vitro studies correlated statistically significant 2D/3D- QSAR models. best 2D-QSAR models reveal positive influence slogp Vander Waal Surface area descriptors while negative polar surface T_2_N_6 bioactivity ideal squared correlation coefficient (r2), cross-validated (q2) high Fisher ratio (F-test) indicating model be relevant. finest 3D-QSAR MLR (Multiple Linear Regression method) provide practical information in characterization differentiation compound binding sites. Moreover, molecular docking performed evaluate antifungal black fungi crystal protein, bioassay scores. Atom economy, feasibility, cost-effectiveness, minimum time, High yields, an additive-free process are foremost advantages developed methodology.

Language: Английский

Citations

4