Recent Advances in Design and Development of Diazole and Diazine Based Fungicides (2014–2023)

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15427 - 15448

Published: July 5, 2024

With fungal diseases posing a major threat to agricultural production, the application of fungicides control related is often considered necessary ensure world's food supply. The search for new bioactive agents has long been priority in crop protection due continuous development resistance against currently used types active compounds. Heterocyclic compounds are an inseparable part core structures numerous lead compounds, these rings constitute pharmacophores significant number developed over past decade by agrochemists. Among heterocycles, nitrogen-based play essential role. To date, diazole (imidazole and pyrazole) diazine (pyrimidine, pyridazine, pyrazine) derivatives make up important series synthetic fungicides. In recent years, many reports have published on design, synthesis, study fungicidal activity scaffolds, but there was lack comprehensive classified review nitrogen-containing scaffolds. Regarding this issue, here we reviewed articles families. current review, molecules synthesized so far based size ring.

Language: Английский

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Design, Synthesis, and Fungicidal Evaluation of Novel N-Methoxy Pyrazole-4-Carboxamides as Potent Succinate Dehydrogenase Inhibitors

Journal of Agricultural and Food Chemistry, Journal Year: 2023, Volume and Issue: 71(5), P. 2610 - 2615

Published: Jan. 25, 2023

Succinate dehydrogenase (SDH, EC 1.3.5.1, also known as complex II) has been recognized one of the most promising targets fungicides. Here, based on binding mode pydiflumetofen with SDH, carbon-carbon double bond was introduced into chemical and then produced target compounds 6a-6o. The enzymatic inhibitory activity structure-activity relationship (SAR) study showed that 2-position 4-position in terminal benzene were positive to increasing activity. Furthermore, fungicidal results greenhouses indicated compound 6o good control effects against wheat powdery mildew (WPM), cucumber (CPM), southern corn rust (SCR), showing its broad-spectrum property. Especially, exhibited 95 75% CPM SCR at 6.25 mg/L, respectively, which are better than (80% 15% SCR), indicating potency is worthy further development.

Language: Английский

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Synthesis, crystal structure, Hirshfeld surface analysis, energy frameworks, molecular docking and DFT calculation of new pyrazole-4-carboxamide compound as antifungal agent

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139145 - 139145

Published: June 30, 2024

Language: Английский

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Microwave-assisted solvent-free synthesis, Hirshfeld surface analysis and DFT studies of 1-(hydroxymethyl)-pyrazoles

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1295, P. 136736 - 136736

Published: Sept. 28, 2023

Language: Английский

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Synthesis, crystal structure and antifungal activities of new quinoline derivatives

Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1277, P. 134792 - 134792

Published: Dec. 13, 2022

Language: Английский

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Synthesis, spectral characterizations, vibrational spectroscopy, DFT-computations, antibacterial, antioxidant, and molecular docking studies of the novel (Z)-2-(5-((10-hexyl-10H-phenothiazin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetic acid

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1292, P. 136008 - 136008

Published: June 20, 2023

Language: Английский

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Synthesis and pesticidal activity of new 1,3,4-oxadiazole thioether compounds containing a trifluoromethylpyrazoyl moiety

Research on Chemical Intermediates, Journal Year: 2022, Volume and Issue: 48(11), P. 4753 - 4767

Published: Sept. 20, 2022

Language: Английский

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Synthesis and Bioactivities of Novel Pyrazole Oxime Derivatives Containing 1,3,4-Oxadiazole Group

Chinese Journal of Organic Chemistry, Journal Year: 2023, Volume and Issue: 43(4), P. 1584 - 1584

Published: Jan. 1, 2023

In order to explore new pyrazole oxime compounds possessing satisfactory bioactivities, sixteen derivatives containing 1,3,4-oxadiazole group were prepared with fenpyroximate selected as lead structure.Their insecticidal activities determined.Preliminary bioassay demonstrated that all the target displayed 100% towards Mythimna separata at 500 μg/mL, of which 5 possessed 80%～100% against 100 μg/mL.Moreover, concentration mortality rates Aphis medicaginis 9 100%, those 3 70%～100% μg/mL.Additionally, 4 exhibited more than 80% Tetranychus cinnabarinus μg/mL.Keywords 1,3,4-oxadiazole; oxime; synthesis; bioactivity 近年来, 含氮杂环衍生物因其具有多种生物活性而 引起人们广泛的关注 [1][2][3][4][5][6][7][8][9][10] .吡唑肟化合物是含氮杂环体 系中的重要分支之一, 在植物保护及生物医药等领域起 到至关重要的作用, 常被用于杀菌 [11] 、杀虫 [12] 、抗植物 病毒 [13] 和抗癌 [14][15] 等活性分子创制中.Kraus 等合成的 唑螨酯(Fenpyroximate)常常用于瘘螨或附线螨等害虫的 防治, 而且该化合物持效期较长 [16] ; Fu 等 [17] 研制的化合 物 A 表现出较优的杀虫活性, 在 200 μg/mL 浓度下对蚜 虫的致死率为 93%, 浓度下对朱砂叶螨的 致死率达 100%; He [18] 报道的化合物 B 对蚜虫、小菜 蛾及螨虫展现出优异的防治效果, 该化合物在 浓度下对蚜虫的防效为 50 浓度 下对小菜蛾的防效为 86.42%, 10 浓度下对螨 Ling [19] 合成的化合物 C 对人肝 癌细胞 SMMC-7721 和人肺癌细胞 H1299 显示出较好的 抗肿瘤作用, 其 IC 值分别是 3.09 和 6.18 μmol/L.同时, 1,3,4-噁二唑衍生物也是一类重要的氮杂环类化合物, 因其具备优异的杀虫 [20] 、杀菌 [21][22] 、除草

Language: Английский

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Modern Approaches to the Synthesis of Pyrazoles (A Review)

Журнал Общей Химии, Journal Year: 2024, Volume and Issue: 94(1), P. 29 - 55

Published: July 2, 2024

Language: Английский

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Experimental and theoretical vibrational analysis, structural conformations, DFT estimations, antibacterial, antifungal, DPPH,H2O2, Nitric oxide scavenging activity drug, in silico molecular docking, and ADMET studies of N-(2-carboxylphenyl) phthalimide (CPPD)

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 414, P. 126119 - 126119

Published: Sept. 24, 2024

Language: Английский

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