Quinoline Synthesis: Nanocatalyzed Green Protocols─An Overview DOI Creative Commons

Rangappa S. Keri,

Srinivasa Budagumpi, Vinayak Adimule

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(42), P. 42630 - 42667

Published: Oct. 14, 2024

Heterocyclic compounds are of great interest in our daily lives. They widely distributed nature and synthesized laboratories. Heterocycles play an important role the metabolism all living cells, including vitamins coenzyme precursors like thiamine riboflavin. Furthermore, heterocyclic systems essential building blocks for creating innovative materials with intriguing electrical, mechanical, biological properties. Also, more than 85% biologically active chemical entities comprise a heterocycle. As result, heterocycle synthesis piqued researchers' curiosity, recent decades, chemists have concentrated on nitrogen-containing cyclic nuclei structures. Quinoline its derivatives exhibit several functions, antimicrobial, anticancer, antimalarial, anti-inflammatory, antihypertensive, antiasthmatic effects. In addition, over hundred quinoline-based drugs available to treat variety disorders. Because importance, researchers developed one-pot synthetic methods employing effective acid/base catalysts (Lewis acids, Brønsted ionic liquids), reagents, transition-metal-based catalysts. These some downsides, longer reaction times, harsher conditions, creation byproducts, costly catalysts, use hazardous solvents, unacceptable economic yield, catalyst recovery. Researchers' focus has switched environmentally friendly quinoline as result these methodologic shortcomings. special qualities, nanocatalysts or nanocomposites offers option quinolines. This review focuses published research articles synthesize substituted derivatives. covers contributions until May 2024, focusing ring mechanistic issues. With aid this review, we anticipate that will be able develop synthesizing

Language: Английский

Tailoring the Surface and Composition of Nanozymes for Enhanced Bacterial Binding and Antibacterial Activity DOI

Jinjie Hou,

Yunlei Xianyu

Small, Journal Year: 2023, Volume and Issue: 19(42)

Published: June 15, 2023

With the advantages of diverse structures, tunable enzymatic activity, and high stability, nanozymes are widely used in medicine, chemistry, food, environment, other fields. As an alternative to traditional antibiotics, attract more attention from scientific researchers recent years. Developing nanozymes-based antibacterial materials opens up a new avenue for bacterial disinfection sterilization. In this review, classification their mechanisms discussed. The surface composition critical efficacy, which can be tailored enhance both binding activity. On one hand, modification enables targeting bacteria that improves performance including biochemical recognition, charge, topography. modulated achieve enhanced single nanozyme-mediated synergistic multiple nanozymes-mediated cascade catalytic applications. addition, current challenges future prospects tailoring applications This review provide insights into design treatments.

Language: Английский

Citations

67
Pristine 2-chloroquinoline-based-thiosemicarbazones as multitarget agents against alzheimer's disease: In vitro and in silico studies of monoamine oxidase (MAO) and cholinesterase (ChE) inhibitors DOI
Saquib Jalil,

Rabia Basri,

Mubashir Aziz

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1306, P. 137841 - 137841

Published: Feb. 22, 2024

Language: Английский

Citations

9
Quinoline–sulfonamides as a multi-targeting neurotherapeutic for cognitive decline:in vitro,in silicostudies and ADME evaluation of monoamine oxidases and cholinesterases inhibitors DOI Creative Commons
Saquib Jalil, Zahid Hussain,

Syed Mobashir Ali Abid

et al.

RSC Advances, Journal Year: 2024, Volume and Issue: 14(13), P. 8905 - 8920

Published: Jan. 1, 2024

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder with multiple enzymes involved.

Language: Английский

Citations

9
Nanobiotic Formulations utilizing Quinoline-based-Triazole functionalized Carbon Quantum Dots via Click Chemistry for Combatting Clinical-Resistant Bacterial Pathogens DOI
Nisha Yadav,

Deeksha Mudgal,

Vivek Mishra

et al.

Indian Journal of Microbiology, Journal Year: 2024, Volume and Issue: unknown

Published: April 6, 2024

Language: Английский

Citations

9
1,2,3-Triazole-containing hybrids with potential antibacterial activity against ESKAPE pathogens DOI

Cui Deng,

Heng Yan,

Jun Wang

et al.

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 244, P. 114888 - 114888

Published: Oct. 29, 2022

Language: Английский

Citations

35
Synthesis, docking, and biological investigations of new coumarin-piperazine hybrids as potential antibacterial and anticancer agents DOI
Kajalben B. Patel,

Sudipta Mukherjee,

Hardik Bhatt

et al.

Journal of Molecular Structure, Journal Year: 2022, Volume and Issue: 1276, P. 134755 - 134755

Published: Dec. 5, 2022

Language: Английский

Citations

29
Current scenario of quinolone hybrids with potential antibacterial activity against ESKAPE pathogens DOI
Jingyue Gao,

Haodong Hou,

Feng Gao

et al.

European Journal of Medicinal Chemistry, Journal Year: 2022, Volume and Issue: 247, P. 115026 - 115026

Published: Dec. 21, 2022

Language: Английский

Citations

29
Synthesis, characterization, molecular dynamic simulation, and biological assessment of cinnamates linked to imidazole/benzimidazole as a CYP51 inhibitor DOI
Ajayrajsinh R. Zala, Dhanji P. Rajani, Iqrar Ahmad

et al.

Journal of Biomolecular Structure and Dynamics, Journal Year: 2023, Volume and Issue: 41(21), P. 11518 - 11534

Published: Jan. 24, 2023

A class of 2-(1H-imidazol-1-yl)-1-phenylethyl cinnamates 6a-6j and 2-(1H-benzo[d]imidazol-1-yl)-1-phenylethyl 7a-7j were synthesized, their synthesis was validated using various spectroscopic techniques like IR, NMR, Mass spectrometry. In addition, the compounds assessed for in-vitro antibacterial against gram-positive gram-negative strains antifungal six different fungal strains. Compounds 6 g, 7 b, 7f, g exhibited significant activity all bacterial ranging from MIC = 12.5-50 µg/mL, considerable MFC 125-200 µg/mL. molecular docking study indicated that 7j could be lodged in active pocket inhibit C. albicans Sterol 14α-demethylase (CYP51) protein via interactions, these studies validate results. Different parameters 100 ns MD simulation are investigated to evaluate dynamic stability protein-ligand complexes. According study, proposed effectively kept interaction structural integrity within 14-demethylase. promising lead searching novel drug-like molecules. Furthermore, silico ADME indicates possess physicochemical properties orally bioavailable.Communicated by Ramaswamy H. Sarma.

Language: Английский

Citations

22
Design and Synthesis of 2-(4-Bromophenyl)Quinoline-4-Carbohydrazide Derivatives via Molecular Hybridization as Novel Microbial DNA-Gyrase Inhibitors DOI Creative Commons
Hany M. Abd El‐Lateef, Ayman Abo Elmaaty,

Lina M. A. Abdel Ghany

et al.

ACS Omega, Journal Year: 2023, Volume and Issue: 8(20), P. 17948 - 17965

Published: May 11, 2023

Microbial DNA gyrase is regarded as an outstanding microbial target. Hence, 15 new quinoline derivatives (5-14) were designed and synthesized. The antimicrobial activity of the afforded compounds was pursued via in vitro approaches. investigated displayed eligible MIC values, particularly against G-positive Staphylococcus aureus species. Consequently, S. supercoiling assay performed, using ciprofloxacin a reference control. Obviously, 6b 10 unveiled IC50 values 33.64 8.45 μM, respectively. Alongside, exhibited value 3.80 μM. Furthermore, significant docking binding score encountered by compound (-7.73 kcal/mol), surpassing (-7.29 kcal/mol). Additionally, both revealed high GIT absorption without passing blood brain barrier. Finally, conducted structure-activity relationship study assured usefulness hydrazine moiety molecular hybrid for either cyclic or opened form.

Language: Английский

Citations

19
Synthesis of Novel Artemisinin, Ciprofloxacin, and Norfloxacin Hybrids with Potent Antiplasmodial Activity DOI Creative Commons

Georgia Vamvoukaki,

Antonia I. Antoniou, Michel Baltas

et al.

Antibiotics, Journal Year: 2024, Volume and Issue: 13(2), P. 142 - 142

Published: Feb. 1, 2024

The synthesis and antiplasmodial evaluation of new hybrids combining the pharmacophore structures artemisinin, ciprofloxacin or norfloxacin, 7-chloroquinoline are reported in this study. first step for all syntheses is obtainment key piperazine esters intermediates bearing drugs norfloxacin. Using these platforms, 18 final compounds were synthesized through a multistep procedure with overall yields ranging between 8 20%. All screened their activity against chloroquine-resistant Plasmodium falciparum FcB1 strain. Compounds 20, 21, 22, 28, an artesunate fragment ciprofloxacin, exhibited IC50 values range 3.5–5.4 nM excellent selectivity indices. Among moiety on two them, 23 24, afforded 1.5 1.9 nM, respectively. They also showed most potent evaluated CQ-resistant Dd2 strain falciparum, demonstrating that those incorporating potent. Finally, combination either norfloxacin moieties single molecular entity proved to substantially enhance when compared administration unconjugated counterparts artesunate/ciprofloxacin artesunate/norfloxacin.

Language: Английский

Citations

4