Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 27, 2024
The
proficient
handling
of
diabetic
wounds,
a
rising
issue
coinciding
with
the
global
escalation
diabetes
cases,
poses
significant
clinical
difficulties.
A
range
biofunctional
dressings
have
been
engineered
and
produced
to
expedite
healing
process
wounds.
This
study
proposes
multifunctional
hydrogel
dressing
for
wound
healing,
which
is
composed
Polyvinyl
Alcohol
(PVA)
N1-(4-boronobenzyl)-N3-(4-boronophenyl)-N1,
N1,
N3,
N3-teramethylpropane-1,
3-diaminium
(TSPBA),
dual-drug
loaded
Gelatin
methacryloyl
(GM)
microgel.
GM
microgel
sodium
fusidate
(SF)
nanoliposomes
(LP)
that
contain
metformin
hydrochloride
(MH).
Notably,
adhesive
self-healing
properties
enhance
their
therapeutic
potential
ease
application.
In
vitro
assessments
indicate
SF-infused
can
eliminate
more
than
98%
bacteria
within
24
h
maintain
sustained
release
over
15
days.
Additionally,
MH
incorporated
has
demonstrated
effective
glucose
level
regulation
duration
exceeding
demonstrates
ability
neutralize
ROS
throughout
entire
process,
predominantly
by
electron
donation
sequestration.
dressing,
integrated
biological
functions
efficient
bactericidal
activity
against
both
MSSA
MRSA
strains,
blood
modulation,
control
active
oxygen
levels,
successfully
promoted
wounds
in
rats
14
exhibited
effectiveness
facilitating
highlighting
its
considerable
promise
translation.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: June 10, 2024
Chiral
1,2,3-triazoles
are
highly
attractive
motifs
in
various
fields.
However,
achieving
catalytic
asymmetric
click
reactions
of
azides
and
alkynes
for
chiral
triazole
synthesis
remains
a
significant
challenge,
mainly
due
to
the
limited
systems
substrate
scope.
Herein,
we
report
an
enantioselective
azidation/click
cascade
reaction
N-propargyl-β-ketoamides
with
readily
available
potent
azido
transfer
reagent
via
copper
catalysis,
which
affords
variety
up
99%
yield
95%
ee
under
mild
conditions.
Notably,
1,5-disubstituted
triazoles
that
have
not
been
accessed
by
previous
also
prepared
good
functional
group
tolerance.
Pharmaceuticals,
Journal Year:
2023,
Volume and Issue:
16(9), P. 1326 - 1326
Published: Sept. 19, 2023
Four
sets
of
previously
synthesized
4-methyl-7-substituted
coumarin
derivatives
were
screened
for
their
in
vitro
anti-inflammatory
and
anti-tubercular
activities.
The
potential
3a–t,
5a–o,
6a–n,
7a–f
compounds
was
evaluated
by
an
anti-denaturation
assay
using
diclofenac
sodium
as
the
reference
standard.
Evaluation
anti-tuberculous
activity
mentioned
performed
Resazurin
test
method
against
four
different
TB
strains
rifampicin
isoniazid
drugs.
Based
on
results,
3o,
5f,
6c,
7d
proved
to
be
most
active
respective
series.
Additionally,
3k–n,
5b–d,
6d–f,
6k,
7a,
7f
found
potent
agents.
In
fact,
exhibited
promising
profiles
compared
standard
structure–activity
connections
revealed
a
few
intriguing
aspects,
indicating
that
presence
electron-donating
nitrogen-rich
fragments
boost
effects
examined
compounds.
However,
electron-withdrawing
substituents
required
