Synthesis, characterization and sensor applications of a new 1,4-naphthoquinone derivative molecule
Chemical Papers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 18, 2025
Language: Английский
Novel sulphonamide-azaheterocycle conjugates and their anti-cancer, anti-inflammatory, anti-diabetic, anti-angiogenesis activity and molecular docking studies
Pradnya Patil,
No information about this author
Nisha Nerlekar,
No information about this author
Sanket Rathod
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et al.
Results in Chemistry,
Journal Year:
2024,
Volume and Issue:
7, P. 101476 - 101476
Published: Jan. 1, 2024
The
present
study
reports
the
synthesis
of
sulphonamide-azaheterocycle
conjugates
(3
a-j)
and
evaluates
its
in
vitro
anticancer
activity
against
breast
cancer
cell
line
(MCF-7)
liver
(HepG2).
compound
3g
was
found
to
be
most
active
with
IC50
values
40.54
±
0.25
μg/ml
MCF
7
55.38
0.18
HepG2
line.
3h
value
36.70
0.90
54.75
0.68
as
compared
standard
drug
5-fluorouracil
(26.08
0.82
45.50
2.35
μg/ml).
compounds
3
a-j
showed
characteristic
changes,
particularly
nucleus,
which
were
observed
through
nuclear
staining
fluorescent
dye
DAPI.
has
shown
strong
anti-inflammatory
31.17
0.23
μg/ml.
Furthermore,
anti-diabetic
exhibited
significant
34.51
1.31
33.87
1.54
acarbose.
Compounds
3a,
3b,
3d,
3f,
displayed
a
antiangiogenic
effect,
an
score
1.34,
1.28,
1.32,
1.41,
1.41
1.45.
Moreover,
silico
bioactivity
prediction
studies
demonstrated
interactions
between
putative
targets.
Results
DFT
analysis
highlighted
that
possesses
favorable
electronic
structure
possibility
having
promising
potential
biological
applications.
binding
affinities
docking
among
all
tested
both
HER2
(PDB:
3PP0)
EGFR
4HJO).
Language: Английский
Synthesis, anticancer and antioxidant activities of novel heterocyclic phenolic hydrazone based derivatives: Investigation of DFT calculation, molecular docking and drug-likeness studies
Ai‐Ping Xing,
No information about this author
Pengbo Zhu,
No information about this author
Bin Zhang
No information about this author
et al.
Journal of Molecular Structure,
Journal Year:
2024,
Volume and Issue:
1319, P. 139523 - 139523
Published: July 31, 2024
Language: Английский
Synthesis and in vitro evaluation of tetrahydropyridines as potential CDK2 and DprE1 inhibitors
Pravin R. Kharade,
No information about this author
Uttam B. Chougale,
No information about this author
D. S. Gaikwad
No information about this author
et al.
Research on Chemical Intermediates,
Journal Year:
2024,
Volume and Issue:
50(4), P. 1777 - 1808
Published: Feb. 12, 2024
Language: Английский
Anti-inflammatory activity and molecular docking study of pyranopyrazole derivatives synthesized using basic ionic liquid
Satish S. Kadam,
No information about this author
D. S. Gaikwad,
No information about this author
Pravin R. Kharade
No information about this author
et al.
Journal of the Iranian Chemical Society,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
Language: Английский
Assessing [DMAP-DABCO]AcO as an effective dual basic ionic liquid for the synthesis of Chromeno[2,3-d]pyrimidine derivatives and Exploring their Anti-Cancer activity through computational analysis
Journal of Molecular Liquids,
Journal Year:
2024,
Volume and Issue:
416, P. 126484 - 126484
Published: Nov. 12, 2024
Language: Английский