In-vitro Study of hybrid Silver Nanoparticles with Humic Acid extracted from Cow Dung against pathogens

Heliyon, Journal Year: 2025, Volume and Issue: 11(1), P. e41636 - e41636

Published: Jan. 1, 2025

Recently, researchers have used silver nanoparticles (AgNPs) coupled with humic acid (HA) as antimicrobial agents. Herein, AgNPs were prepared and for their activities. The as-prepared characterized by an atomic force microscope (AFM), X-ray powder diffraction (XRD), zeta potential, sizer, Fourier-transform infrared (FT-IR) spectroscopy, UV-VIS spectrophotometer. Moreover, human plasma, varied salt concentrations, pH levels stability confirmation using a antibacterial activities minimal bactericidal concentration (MBC) of determined disk diffusion broth dilution methods, respectively, against identified Staphylococcus aureus, Streptococcus pyogene, Pseudomonas aeruginosa, Escherichia coli, which are extracted from cow dung. AgNPs' peak in the UV-Vis spectral range showed maximal absorption at 415 nm. displayed distinctive under all circumstances, demonstrating stability. FT-IR functional groups such hydroxyl, carboxylic acids, carbonyl, ester, ether groups. particles face-centered cubic (FCC) structure, according to XRD. had spherical shape, high negative polydisperse nature, average size 25.43 was found be 2.5 mg/mL, MBC AgNPs/HA 5 mg/mL. result indicated that as-synthesizedAgNPs/HA more effective inhibiting studied microorganisms, can attributed therapeutic use coated acids.

Language: Английский

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Synthesis and Characterization of Coated CoFe₂O₄ Nanoparticles with Biocompatible Compounds and In Vitro Toxicity Assessment on Glioma Cell Lines

Advanced Materials Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Rapid advances in the development of nanotechnology recent years have led to functional magnetic nanoparticle types (MNPs) with different properties. The diverse applications these nanoparticles make them a desirable candidate for use biomedical areas due their exclusive chemical and physical present work is conducted study vitro biocompatibility CoFe 2 O 4 @shell surface coatings (shell: ascorbic acid (AA), dextran (DEX), polyethyleneimine (PEI). cytotoxicity coated screened toward glioma cancer line (C6) fibroblast cell (L929) using an MTT assay. NPs are synthesized co‐precipitation method together hydrothermal synthesis characterized regarding structural properties state‐of‐the‐art techniques. Results showed particles consistent crystal structure average crystallite size range 16–18 nm. For NPs, only slight increase Hc found except @PEI NPs. comparative analysis cytotoxic effects on L929 cells shows that samples much more specific brain tumor cells, especially it also indicates significant efficacy cells.

Language: Английский

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Synthesis and Characterization of Brucine Gold Nanoparticles for Targeted Breast Cancer Therapy: Mechanistic Insights Into Apoptosis and Antioxidant Disruption in MCF‐7 Cells

Biotechnology and Applied Biochemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

ABSTRACT Globally, breast cancer continues to be the leading type of affecting women, with rising mortality rates projected by 2030. This highlights importance developing new, affordable treatments, like drug delivery systems that use nanoparticles. Gold nanoparticles (AuNPs), including their exceptional optical and physical attributes, make them an attractive vehicle for targeted treatment, allowing accurate focused medication directly cancerous cells while reducing harmful side effect. study focuses on synthesis characterization brucine‐gold (BRU‐AuNPs) therapy evaluating antioxidant apoptotic mechanism. BRU‐AuNPs were synthesized characterized (UV–Vis spectroscopy, Fourier transform infrared [FTIR], scanning electron microscopy [SEM], x‐ray diffraction [XRD], dynamic light scattering [DLS], zeta potential) confirm successful synthesis, size, stability. In vitro studies assessed using MCF‐7 cell lines evaluate cytotoxicity, balance, reactive oxygen species (ROS) generation, mitochondrial membrane potential, apoptosis induction, migration, pro‐apoptotic gene expression. Characterization results confirmed average crystal size 85.40 nm stable surface charge. Results demonstrated reduced viability in a dose‐dependent manner, IC 50 value 11.47 µg/mL. Treatment altered increased ROS depolarized membranes, induced apoptosis. Additionally, inhibited migration upregulated The exhibit potential as highly effective system treatment. Their ability deliver BRU tumor effects enhancing therapeutic efficacy underscores promise advancing therapy. Further are warranted explore clinical optimize outcomes.

Language: Английский

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Combining Bacteriogenic Fluorescent Carbon Nanoparticles with ZnO Nanoparticles: A Novel Approach Against Antibiotic-Resistant Clinical Escherichia coli Strains

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 16, 2025

Language: Английский

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Translational paradigm in nanodiagnostics applications of functionalized zinc oxide nanoforms interface for pathogenic virus diagnostics

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: 509, P. 161260 - 161260

Published: March 5, 2025

Language: Английский

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Simple and robust fabrication and characterization of conductive carbonized nanofibers loaded with gold nanoparticles for bone tissue engineering applications

Materials Science and Engineering C, Journal Year: 2020, Volume and Issue: 117, P. 111226 - 111226

Published: July 3, 2020

Language: Английский

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The Puzzling Potential of Carbon Nanomaterials: General Properties, Application, and Toxicity

Nanomaterials, Journal Year: 2020, Volume and Issue: 10(8), P. 1508 - 1508

Published: July 31, 2020

Being a member of the nanofamily, carbon nanomaterials exhibit specific properties that mostly arise from their small size. They have proved to be very promising for application in technical and biomedical field. A wide spectrum use implies inevitable presence environment, thus potentially endangering whole nature. Although scientists worldwide conducted research investigating impact these materials, it is evident there are still significant gaps concerning knowledge mechanisms, as well prolonged chronic exposure effects. This manuscript summarizes most prominent representatives nanomaterial groups, giving brief review general physico-chemical properties, common use, toxicity profiles. Toxicity was presented through genotoxicity activation cell signaling pathways, both including vitro vivo models, consequential outcomes. Moreover, acute fullerenol, one commonly investigated members, briefly final part this review. Thinking can greatly help us improve our lives, but also obliges deeply comprehensively investigate all possible consequences could pure-hearted scientific ambitions work.

Language: Английский

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Versatile delivery systems for non-platinum metal-based anticancer therapeutic agents

Coordination Chemistry Reviews, Journal Year: 2021, Volume and Issue: 441, P. 213975 - 213975

Published: May 5, 2021

Language: Английский

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The DNA damage potential of quantum dots: Toxicity, mechanism and challenge

Environmental Pollution, Journal Year: 2022, Volume and Issue: 317, P. 120676 - 120676

Published: Nov. 14, 2022

Language: Английский

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Environmental Toxicity of Engineered Carbon Nanoparticles

Published: Jan. 1, 2024

The employment of nanotechnological tools is increasing at a very rapid pace in modern agricultural systems. Among gamut nanoparticles employed, carbon are also being explored as potential for plant productivity. Due to their broad spectrum biocidal activity, they projected future biocontrol agents. However, the multifarious approach not only reduces chances resistance pathogens but puts forward off-target effects using these nanoparticles. practice agriculture highly reliant on plant–microbe symbiotic relations. Therefore, nanoparticle accumulation systems could disrupt this relationship. interference with genetic material plants and microbes can lead generation mutant strains serotypes unpredictable outcomes. Additionally, repetitive exposure rhizosphere nanomaterials significant alterations microbiome that might significantly change In current chapter, we have highlighted toxicity associated originating from harmful alter We tried highlight mechanism governing beneficial soil microbes.

Language: Английский

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