Molecules,
Journal Year:
2024,
Volume and Issue:
29(18), P. 4360 - 4360
Published: Sept. 13, 2024
Carboxymethyl
chitosan
(CMCS)
hydrogels
have
been
investigated
in
biomedical
research
because
of
their
versatile
properties
that
make
them
suitable
for
various
medical
applications.
Key
are
especially
valuable
use
include
biocompatibility,
tailored
solid-like
mechanical
characteristics,
biodegradability,
antibacterial
activity,
moisture
retention,
and
pH
stimuli-sensitive
swelling.
These
features
offer
advantages
such
as
enhanced
healing,
promotion
granulation
tissue
formation,
facilitation
neutrophil
migration.
As
a
result,
CMCS
favorable
materials
applications
biopharmaceuticals,
drug
delivery
systems,
wound
engineering,
more.
Understanding
the
interactions
between
biological
with
focus
on
influence
cellular
behavior,
is
crucial
leveraging
versatility.
Because
constantly
growing
interest
its
derivative
applications,
present
review
aims
to
provide
updated
insights
into
potential
based
recent
findings.
Additionally,
we
comprehensively
elucidated
mechanisms
underlying
actions
these
settings.
In
summary,
this
paper
recapitulates
data
gathered
from
current
literature,
offering
perspectives
further
development
utilization
carboxymethyl
contexts.
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(10), P. e20521 - e20521
Published: Sept. 28, 2023
Trauma
can
damage
the
structural
integrity
of
skin
leading
to
its
function
being
affected.
There
is
an
urgent
clinical
need
for
innovative
therapeutic
wound
dressings.
However,
several
challenges
persist
despite
current
demands.
The
development
and
application
functional
dressings
offer
a
novel
approach
address
subcutaneous
soft
tissue
defects.
Amniotic
membrane
as
ideal
biological
multifunctional
material
covering
surface
has
been
reported
in
clinic.
applications
amniotic
still
have
limitations,
such
thinness
mechanically
weak.
In
this
paper,
we
employed
decellularized
human
(dHAM)
bioactive
extracellular
matrix
(ECM)
modified
it
through
methacrylate
(MA)
grafting
engineering
purposes,
resulting
photosensitive
dECMMA.
Subsequently,
utilized
photosensitizer
achieve
photopolymerization
dECMMA
with
GelMA
hydrogel,
successfully
creating
composite
hydrogel
termed
dECMMA/GelMA.
This
not
only
inherits
favorable
physicochemical
properties
hydrogels
but
also
maintains
comparable
levels
bioactivity
dHAM
itself,
supporting
cell
proliferation,
migration,
angiogenesis,
retaining
significant
anti-inflammatory
capacity.Additionally,
evaluated
reparative
effect
designed
dECMMA/GelMA
on
rabbit
We
demonstrated
that
promoted
healing
re-epithelization.
These
findings
highlight
substantial
benefits
potential
practical
solution
treatment
damage.
Furthermore,
research
provides
new
strategy
designing
manufacturing
exceptional
efficacy
future.
Comprehensive Reviews in Food Science and Food Safety,
Journal Year:
2024,
Volume and Issue:
23(6)
Published: Nov. 1, 2024
Abstract
Global
environmental
concerns
about
non‐degradable
packaging
materials
are
increasing.
Carboxymethyl
chitosan
(CMCS),
a
polysaccharide
widely
used
in
the
food
industry,
has
gained
attention
field
of
packaging.
Due
to
its
biodegradability,
film‐forming
ability,
and
biocompatibility,
CMCS
emerged
as
sustainable
option
for
degradable
functional
materials,
offering
solutions
plastic
pollution
waste
issues.
This
review
explores
delivery
material,
detailing
synthesis
methods,
optimal
preparation
conditions,
properties
post‐carboxymethylation,
applications
alongside
safety
assessments.
It
summarizes
physicochemical
interactions
CMCS‐based
composites
their
impact
on
relevant
properties,
highlighting
CMCS's
potential
green
strategy
smart
active
materials.
Additionally,
it
presents
latest
advancements
industry
over
past
decade.
exhibits
good
biocompatibility
antibacterial
functionality
films
is
enhanced
through
modification
polymerization.
matrix
preservation
or
coatings
carrier
ingredients,
thereby
improving
encapsulation
efficiency
storage
stability
components.
comprehensively
outlines
filling
gaps
existing
literature,
laying
theoretical
foundation
development
technology.
provides
reference
further
research,
emphasizing
need
investigate
molecular
structure
chemical
optimize
safety,
fully
tapping
into
industry.
Marine Drugs,
Journal Year:
2024,
Volume and Issue:
22(10), P. 450 - 450
Published: Sept. 30, 2024
The
aim
of
the
current
study
is
to
develop
chitosan-based
biomaterials
which
can
sustainably
release
acetylsalicylic
acid
while
presenting
significant
biological
activity.
Herein,
an
innovative
ionic
bonding
strategy
between
hydroxypropyl
trimethyl
ammonium
chloride
chitosan
(HACC)
and
(AA)
was
proposed,
skillfully
utilizing
electrostatic
attraction
bond
achieve
controlled
drugs.
Based
on
this
point,
six
crosslinked
Biomaterials Research,
Journal Year:
2024,
Volume and Issue:
28
Published: Jan. 1, 2024
One
of
the
bacterial
infections
caused
by
tympanic
membrane
perforation
is
otitis
media
(OM).
Middle
ear
inflammation
causes
continuous
pain
and
can
be
accompanied
aftereffects
such
as
facial
nerve
paralysis
if
repeated
chronically.
Therefore,
it
necessary
to
develop
an
artificial
(TM)
that
effectively
regenerate
eardrum
due
easy
implantation
removal
OM
inflammation.
In
this
study,
we
synthesized
hydrogel
mixing
gelatin
polyacrylamide.
Cefuroxime
sodium
salt
was
then
incorporated
into
both
TM
treat
OM.
Cytotoxicity
experiments
confirmed
biocompatibility
hydrogels
equipped
with
antibiotics,
conducted
drug
release
antibacterial
examine
release.
Through
experiments,
have
verified
excellent
biocompatibility,
ability,
effectiveness
hydrogel.
It
holds
potential
serve
effective
strategy
for
treating
regenerating
a
delivery
substance.
