Design of bone scaffolds with calcium phosphate and its derivatives by 3D printing: A review

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 151, P. 106391 - 106391

Published: Jan. 9, 2024

Language: Английский

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Buckling of a sandwich beam with carbon nano rod reinforced composite and porous core under axially variable forces by considering general strain

Results in Engineering, Journal Year: 2024, Volume and Issue: 21, P. 101945 - 101945

Published: Feb. 24, 2024

Scientists have explored alternative reinforcements to improve the mechanical properties of composite structures in recent years due high financial and environmental costs associated with synthesis carbon nanotubes graphene plates. A sandwich beam reinforced nanorods (CNRRCs) synthesized from potato waste a porous core is examined this study. The nonlocal strain gradient theory general are applied structure under axially variable force. Based on sinusoidal theory, shear deformation used calculate displacement fields beams. Equilibrium equations derived using higher order theory. mixture rule determine face sheet, including Young's modulus, Poisson's ratio. axial compression force external work. Ritz method different boundary conditions, final derived, then buckling stiffness matrices finally, solved critical load determined. An analysis for conducted made waste. In addition, various parameters such as parameter, non-local volume fraction nanorods, thickness ratio discussed. study, recycled materials found increase beams loads, which lower than more economical nanotubes. Graphene platelets stiffness-to-cost nanorods. Carbon other hand, cost

Language: Английский

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Dual-functional Hydroxyapatite scaffolds for bone regeneration and precision drug delivery

Journal of the mechanical behavior of biomedical materials/Journal of mechanical behavior of biomedical materials, Journal Year: 2024, Volume and Issue: 157, P. 106661 - 106661

Published: July 14, 2024

Language: Английский

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Quality by design based ecofriendly HPLC analytical method for simultaneous quantification of erastin and lenalidomide in mesoporous silica nanoparticles

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 14, 2025

Abstract The aims of this work to optimize and validate a RP-HPLC method quantify erastin (ERT) lenalidomide (LND) in mesoporous silica nanoparticles (MSNs). Design Experiments (DoE) strategy optimized the method. independent variables were buffer ratio, pH, flow rate injection volume. dependent retention time (Rt), Peak area, resolution between peaks analytes. conditions were: ratio 68% methanol 32%, 0.8 mL/min, pH 5.8, volume 10 µL. ICH Q2(R1) recommendations followed validation demonstrated linearity more than 0.99 for both ERT LND. LOD LOQ 0.75 1.62 ng/mL ERT; LND 31.25 50 ng/mL. specificity established was unaffected by MSNs matrix. drugs-loaded analyzed using suggested technique. % entrapment efficiency found be 72.65 79.50%, drug loading 14 17% MSNs, respectively. used check in-vitro release from ERT-LND@MSNs. Surface properties synthesized checked through particle SEM analysis. developed analytical eco-friendly according AGREE analysis GAPI

Language: Английский

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Optimizing Wound Healing: Examining the Influence of Biopolymers Through a Comprehensive Review of Nanohydrogel-Embedded Nanoparticles in Advancing Regenerative Medicine

The International Journal of Lower Extremity Wounds, Journal Year: 2024, Volume and Issue: unknown

Published: April 15, 2024

Nanohydrogel wound healing refers to the use of nanotechnology-based hydrogel materials promote wounds. Hydrogel dressings are made up a three-dimensional network hydrophilic polymers that can absorb and retain large amounts water or other fluids. Nanohydrogels take this concept further by incorporating nanoscale particles structures into matrix. These nanoparticles be various materials, such as silver, zinc oxide, derived from natural substances like chitosan. The inclusion provide additional properties benefits dressings. designed release bioactive substances, growth factors drugs, in controlled manner. This allows for targeted delivery therapeutics site, promoting reducing inflammation. Nanoparticles reinforce structure hydrogels, improving their mechanical strength stability. often incorporate antimicrobial nanoparticles, silver oxide. have shown effective activity against wide range bacteria, fungi, pathogens. By them dressings, nanohydrogels help prevent reduce risk infection encapsulate factors, peptides, sustained therapeutic agents promotes facilitating cell proliferation, inflammation, supporting tissue regeneration. unique nanohydrogels, including ability maintain moist environment deliver agents, accelerate process. creating an optimal repair, faster more efficient

Language: Английский

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A review on hollow nanostructures, its derived composites: Preparation, structural control, alterations, and their utilization as an electrode for supercapacitors, rechargeable batteries and electrocatalysis

Journal of Energy Storage, Journal Year: 2024, Volume and Issue: 98, P. 113143 - 113143

Published: Aug. 3, 2024

Language: Английский

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Experimental free vibration and tensile test results of a five-layer sandwich plate by comparing various carbon nanostructure reinforcements with SMA

Heliyon, Journal Year: 2024, Volume and Issue: 10(10), P. e31164 - e31164

Published: May 1, 2024

Considering to need for the sensitive and destructive industries high stiffness low weight, an experimental free vibration tensile test results of a five-layer sandwich plate by comparing various carbon nano structures reinforcements with SMA is discussed. The effect reinforcements, including nanostructures (carbon nanotubes (CNT), nanorods (CNRs), Graphene platelets (GPLs)) nitinol shape memory alloy (SMA) wire on behavior foam core investigated. purpose novelty this work are compare different vibrations so that using comparison, one can choose best according needs desired industry more suitable economic conditions. 1% weight fraction epoxy resin, GPLs, CNTs, CNRs increase Young's modulus face sheets 30%, 25%, 5.8%, respectively. In work, structure model be suggested, numerically analyzed. special advantage research compared previous construction model. This simple modeling preliminary examination five layers experimentally. Also, composite made vacuum pump method, which does not have disadvantages manual method completely optimal. At first, shear moduli unidirectional glass fiber (UGF) calculated performing test. To examine all aspects during construction, in article separately UGF, then cores connected glue. following, equations motion derived refined first-order deformation theory (RFSDT) employing Hamilton's principle. Using Halpin-Tsai equation extended rule mixture, mechanical properties reinforced obtained. According Brinson model, constitutive presented. influence parameters such as side ratio, thickness CNRs, GPLs wire, angle, temperature changes dimensionless fundamental frequency also represented. natural orthotropic plates considering higher than without reinforcements. By increasing aspect ratio (a/h), increases, while decreases. For two-layer square angular asymmetric laminated (-θ/θ), minimum occurred at placement angle approximately equal 26 64 degrees. highest related its strength because it placed further from middle plane. plate, whose GPLs.

Language: Английский

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Experimental and theoretical results for bending and buckling of a five-layer sandwich plate reinforced by carbon nanotubes/carbon nanorods/graphene platelets/shape memory alloy based on RFSDT

Archive of Applied Mechanics, Journal Year: 2024, Volume and Issue: 94(8), P. 2151 - 2173

Published: June 13, 2024

Language: Английский

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Exploring the adsorption potential of lanthanum (III), samarium (III), and cerium (III) from aqueous solutions utilizing activated carbon derived from date seeds

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 163, P. 112331 - 112331

Published: March 21, 2024

Language: Английский

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Revolutionizing Bone Repair and Regeneration: The Role of Machine Learning in Designing Advanced Nanocomposite Hydrogels

Polymers for Advanced Technologies, Journal Year: 2025, Volume and Issue: 36(4)

Published: March 28, 2025

ABSTRACT Bone repair is a complex biological process requiring dynamic interplay between cellular mechanisms, molecular signaling, and environmental factors. The intricate stages of bone healing, including hematoma formation, inflammation, soft callus development, hard remodeling, are driven by coordinated responses pathways. Proinflammatory cytokines, growth factors, the extracellular matrix play critical roles in promoting osteogenesis angiogenesis. Factors such as age, systemic health, mechanical stability significantly influence efficiency. To address limitations natural advancements regenerative medicine have introduced innovative materials like nanocomposite hydrogels, which mimic microenvironment enhance function. Semi‐interpenetrating network (semi‐IPN) hydrogels emerged promising tool for tissue engineering. Combining crosslinked non‐crosslinked polymers, these offer balance stability, functionality, controlled degradation. Semi‐IPN provide structural support, facilitate cell attachment, enable sustained release bioactive molecules. Their flexibility adaptability make them suitable encapsulating stem cells targeted regeneration. Moreover, nonsurgical surgical scaffold delivery methods, ranging from injectable to 3D‐printed magnetically guided scaffolds, expanded horizons strategies, reduced invasiveness, improved patient outcomes. This review explores dynamics role regeneration, advanced construction strategies semi‐IPN repair. By integrating polymer science, nanotechnology, bioengineering, represent transformative shift addressing defects, paving way therapeutic approaches medicine. With ongoing advancements, technologies hold significant potential improve effectiveness accessibility solutions.

Language: Английский

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