Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Journal Year: 2021, Volume and Issue: 15(12), P. 18895 - 18930

Published: Dec. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Language: Английский

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Bacterial Cellulose-Based Composite Scaffolds for Biomedical Applications: A Review

ACS Sustainable Chemistry & Engineering, Journal Year: 2020, Volume and Issue: 8(20), P. 7536 - 7562

Published: April 30, 2020

Bacterial cellulose (BC), with non-toxicity, high purity, and biocompatibility, has been considered as a versatile candidate for various biomedical applications. Recently, the fabrication of BC-based composite scaffolds compounded other ingredients such nanoparticles polymers received extensive investigation, which enabled development numerous promising products. Additionally, BC-derived nanocrystals (BCNCs) nanofibrils (BCNFs) have proven to be reinforcing agents in variety polymeric In this review, we summarize recent preparation strategies BCNCs- BCNFs-containing their advances applications, including wound healing, tissue engineering, drug delivery, well tumor cell culture cancer treatment. Finally, present challenges future perspectives

Language: Английский

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Persistent and Stable Organic Radicals: Design, Synthesis, and Applications

Chem, Journal Year: 2020, Volume and Issue: 7(2), P. 288 - 332

Published: Nov. 20, 2020

Language: Английский

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Synthesis, Applications, and Prospects of Graphene Quantum Dots: A Comprehensive Review

Small, Journal Year: 2021, Volume and Issue: 18(2)

Published: Sept. 22, 2021

Abstract Graphene quantum dot (GQD) is one of the youngest superstars carbon family. Since its emergence in 2008, GQD has attracted a great deal attention due to unique optoelectrical properties. Non‐zero bandgap, ability accommodate functional groups and dopants, excellent dispersibility, highly tunable properties, biocompatibility are among most important characteristics GQDs. To date, GQDs have displayed significant momentum numerous fields such as energy devices, catalysis, sensing, photodynamic photothermal therapy, drug delivery, bioimaging. As this field rapidly evolving, there strong need identify emerging challenges recent advances, mainly because some novel applications innovations on ease synthesis not systematically reviewed earlier studies. This feature article provides comparative balanced discussion advances synthesis, Besides, current future prospects these carbon‐based nanomaterials also highlighted. The outlook provided review points out that research boundless, particularly if upcoming studies focus purification eco‐friendly along with improving photoluminescence yield production

Language: Английский

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Nanoscale Covalent Organic Framework for Combinatorial Antitumor Photodynamic and Photothermal Therapy

ACS Nano, Journal Year: 2019, Volume and Issue: 13(11), P. 13304 - 13316

Published: Nov. 5, 2019

Despite the excellent photodynamic and photothermal properties of organic molecular photosensitizers (PSs) agents (PTAs), such as porphyrin naphthalocyanine, their poor water solubility severely impedes biological applications. Covalent frameworks (COFs), an emerging class crystalline porous materials, possess free active end groups (bonding defects) large inner pores, which make them ideal type nanocarriers for loading hydrophobic PSs PTAs by both bonding defect functionalization (BDF) guest encapsulation approaches to obtain multifunctional nanomedicines PDT/PTT combination therapy. In this work, we report a nanoscale COF (NCOF) prepared via facile synthetic approach under ambient conditions. Furthermore, dual-modal therapeutic nanoagent, VONc@COF-Por (3), is successfully fabricated stepwise BDF processes. The covalently grafted porphyrinic PS (Por) noncovalently loaded naphthalocyanine PTA (VONc) are independently responsible PDT PTT functionalities nanoagent. Upon visible (red LED) NIR (808 nm laser) irradiation, (3) displayed high 1O2 generation conversion ability (55.9%), consequently providing combined effect on inhibiting MCF-7 tumor cell proliferation metastasis, was well evidenced in vitro vivo experiments. We believe that results obtained herein can significantly promote development NCOF-based biomedical

Language: Английский

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Advanced bioactive nanomaterials for biomedical applications

Exploration, Journal Year: 2021, Volume and Issue: 1(3)

Published: Dec. 1, 2021

Bioactive materials are a kind of with unique bioactivities, which can change the cellular behaviors and elicit biological responses from living tissues. came into spotlight in late 1960s when researchers found that such as bioglass could react surrounding bone tissue for regeneration. In following decades, advances nanotechnology brought new development opportunities to bioactive nanomaterials. nanomaterials not simple miniaturization macroscopic materials. They exhibit bioactivities due their nanoscale size effect, high specific surface area, precise nanostructure, significantly influence interactions systems. Nowadays, have represented an important exciting area research. Current future applications ensure academic clinical importance. This review summaries recent field nanomaterials, evaluate factors bioactivities. Then, range potential biomedical discussed. Furthermore, limitations, challenges, also

Language: Английский

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Multifunctional phototheranostic nanomedicine for cancer imaging and treatment

Materials Today Bio, Journal Year: 2019, Volume and Issue: 5, P. 100035 - 100035

Published: Nov. 7, 2019

Cancer, as one of the most life-threatening diseases, shows a high fatality rate around world. When improving therapeutic efficacy conventional cancer treatments, researchers also conduct extensive studies into alternative approaches, which are safe, valid, and economical. Phototherapies, including photodynamic therapy (PDT) photothermal (PTT), tumor-ablative function-reserving oncologic interventions, showing strong potential in clinical treatment. During phototherapies, non-toxic phototherapeutic agents can be activated upon light irradiation to induce cell death without causing much damage normal tissues. Besides, with rapid development nanotechnology past decades, phototheranostic nanomedicine has attracted tremendous interests aiming continuously refine their performance. Herein, we reviewed recent progress for improved therapy. After brief introduction principles related PDT PTT, existing works on developing by mainly focusing categories applications, particularly phototherapy-synergized immunotherapy, comprehensively reviewed. More importantly, conclusion future challenges from our point view delivered last part this article.

Language: Английский

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Nanomaterials in the environment, human exposure pathway, and health effects: A review

The Science of The Total Environment, Journal Year: 2020, Volume and Issue: 759, P. 143470 - 143470

Published: Nov. 17, 2020

Language: Английский

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Fluorescent-based nanosensors for selective detection of a wide range of biological macromolecules: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 206, P. 115 - 147

Published: Feb. 26, 2022

Thanks to their unique attributes, such as good sensitivity, selectivity, high surface-to-volume ratio, and versatile optical electronic properties, fluorescent-based bioprobes have been used create highly sensitive nanobiosensors detect various biological chemical agents. These sensors are superior other analytical instrumentation techniques like gas chromatography, high-performance liquid capillary electrophoresis for being biodegradable, eco-friendly, more economical, operational, cost-effective. Moreover, several reports also highlighted application in the early detection of biomarkers associated with drug-induced organ damage liver, kidney, or lungs. In present work, we comprehensively overviewed electrochemical that employ nanomaterials (nanoparticles/colloids quantum dots, carbon nanoscaled metal-organic frameworks, etc.) a variety macromolecules based on fluorescent emission spectra. addition, most important mechanisms methods sense amino acids, protein, peptides, enzymes, carbohydrates, neurotransmitters, nucleic vitamins, ions, metals, electrolytes, blood gases, drugs (i.e., anti-inflammatory agents antibiotics), toxins, alkaloids, antioxidants, cancer biomarkers, urinary metabolites urea, uric acid, creatinine), pathogenic microorganisms were outlined compared terms selectivity sensitivity. Altogether, small dimensions capability these nanosensors sensitive, label-free, real-time sensing chemical, biological, pharmaceutical could be array-based screening in-vitro in-vivo diagnostics. Although nanoprobes widely applied determining macromolecules, unfortunately, they many challenges limitations. Efforts must made minimize limitations utilizing an emphasis commercial developments. We believe current review can foster wider incorporation nanomedicine will particular interest researchers working fluorescence technology, material chemistry, coordination polymers, related research areas.

Language: Английский

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MoS2-based nanocomposites for cancer diagnosis and therapy

Bioactive Materials, Journal Year: 2021, Volume and Issue: 6(11), P. 4209 - 4242

Published: April 27, 2021

Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used biomedical research. Especially, MoS2-nanomaterials attracted more attention cancer diagnosis treatment recently because their unique physical chemical properties. MoS2 can adsorb various biomolecules drug molecules via covalent or non-covalent interactions it easy to modify possess high specific surface area, improving its tumor targeting colloidal stability, well accuracy sensitivity detecting biomarkers. At same time, near-infrared (NIR) window, has excellent optical absorption prominent photothermal conversion efficiency, which achieve NIR-based phototherapy NIR-responsive controlled drug-release. Significantly, modified MoS2-nanocomposite specifically respond microenvironment, leading accumulation site increased, reducing side effects on non-cancerous tissues, improved therapeutic effect. In this review, we introduced latest developments MoS2-nanocomposites therapy, mainly focusing biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, combination therapy. Furthermore, also discuss current challenges prospects treatment.

Language: Английский

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