pH/Glucose Dual Responsive Metformin Release Hydrogel Dressings with Adhesion and Self-Healing via Dual-Dynamic Bonding for Athletic Diabetic Foot Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(2), P. 3194 - 3207

Published: Jan. 31, 2022

In view of the lack a specific drug-sustained release system that is responsive to chronic wounds type II diabetic foot, and demands for frequent movement at foot wound, pH/glucose dual-responsive metformin-released adhesion-enhanced self-healing easy-removable antibacterial antioxidant conductive hemostasis multifunctional phenylboronic acid benzaldehyde bifunctional polyethylene glycol-co-poly(glycerol sebacic acid)/dihydrocaffeic l-arginine cografted chitosan (PEGS-PBA-BA/CS-DA-LAG, denoted as PC) hydrogel dressings were constructed based on double dynamic bond Schiff-base phenylboronate ester. It was further demonstrated PC promotes wound healing by reducing inflammation enhancing angiogenesis in rat model. addition, addition metformin (Met) graphene oxide (GO), well their synergy, confirmed better promote repair vivo. summary, PC/GO/Met hydrogels with stimuli-responsive ability easy removability have shown promoting effect athletic provide local-specific drug dual-response strategy treatment feet.

Language: Английский

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Antibacterial biomaterials for skin wound dressing

Asian Journal of Pharmaceutical Sciences, Journal Year: 2022, Volume and Issue: 17(3), P. 353 - 384

Published: Jan. 24, 2022

Bacterial infection and the ever-increasing bacterial resistance have imposed severe threat to human health. And contamination could significantly menace wound healing process. Considering sophisticated process, novel strategies for skin tissue engineering are focused on integration of bioactive ingredients, antibacterial agents included, into biomaterials with different morphologies improve cell behaviors promote healing. However, a comprehensive review anti-bacterial dressing enhance has not been reported. In this review, various as dressings will be discussed. Different kinds agents, including antibiotics, nanoparticles (metal metallic oxides, light-induced agents), cationic organic others, their recent advances summarized. Biomaterial selection fabrication structures forms, films, hydrogel, electrospun nanofibers, sponge, foam three-dimension (3D) printed scaffold regeneration, elaborated Current challenges future perspectives presented in multidisciplinary field. We envision that provide general insight elegant design further refinement dressing.

Language: Английский

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Bacterial Growth-Induced Tobramycin Smart Release Self-Healing Hydrogel for Pseudomonas aeruginosa-Infected Burn Wound Healing

ACS Nano, Journal Year: 2022, Volume and Issue: 16(8), P. 13022 - 13036

Published: Aug. 3, 2022

Burns are a common health problem worldwide and highly susceptible to bacterial infections that difficult handle with ordinary wound dressings. Therefore, burn repair is extremely challenging in clinical practice. Herein, series of self-healing hydrogels (QCS/OD/TOB/PPY@PDA) good electrical conductivity antioxidant activity were prepared on the basis quaternized chitosan (QCS), oxidized dextran (OD), tobramycin (TOB), polydopamine-coated polypyrrole nanowires (PPY@PDA NWs). These Schiff base cross-links between aminoglycoside antibiotic TOB OD enable be slowly released responsive pH. Interestingly, acidic substances during bacteria growth process can induce on-demand release TOB, avoiding abuse antibiotics. The antibacterial results showed QCS/OD/TOB/PPY@PDA9 hydrogel could kill high concentrations Pseudomonas aeruginosa (PA), Staphylococcus aureus, Escherichia coli short time bactericidal effect for up 11 days an agar plate diffusion experiment, while showing vivo activity. Excellent long-lasting properties make it suitable severely infected wounds. Furthermore, incorporation PPY@PDA endowed near-infrared (NIR) irradiation assisted drug-resistant bacteria, conductivity, Most importantly, PA-infected model, more effectively controlled inflammation levels promoted collagen deposition, vascular generation, earlier closure compared Tegaderm smart delivery advantageous bacterial-infected healing.

Language: Английский

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Antibacterial adhesive self-healing hydrogels to promote diabetic wound healing

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 146, P. 119 - 130

Published: April 25, 2022

Language: Английский

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Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Polymers, Journal Year: 2022, Volume and Issue: 14(15), P. 3023 - 3023

Published: July 26, 2022

Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced solved. Hydrogels have been proposed excellent candidates these they promising properties the mentioned including biocompatibility, biodegradability, great absorption capacity tunable mechanical properties. However, depending on material or manufacturing method, resulting hydrogel may not up to specific task it is designed, thus different approaches enhance performance requirements of application in question. The main purpose this review article was summarize most recent trends technology, going through used polymeric materials popular synthesis methods years, strategies enhancing hydrogels' properties, cross-linking manufacture composite hydrogels. In addition, secondary objective briefly discuss other novel applications hydrogels that past few years drawn a lot attention.

Language: Английский

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Recent progress of antibacterial hydrogels in wound dressings

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100582 - 100582

Published: Feb. 16, 2023

Hydrogels are essential biomaterials due to their favorable biocompatibility, mechanical properties similar human soft tissue extracellular matrix, and repair properties. In skin wound repair, hydrogels with antibacterial functions especially suitable for dressing applications, so novel hydrogel dressings have attracted widespread attention, including the design of components, optimization preparation methods, strategies reduce bacterial resistance, etc. this review, we discuss fabrication challenges associated crosslinking methods chemistry materials. We investigated advantages limitations (antibacterial effects mechanisms) different components in achieve good properties, response stimuli such as light, sound, electricity resistance. Conclusively, provide a systematic summary findings (crosslinking methods) an outlook on long-lasting effects, broader spectrum, diversified forms, future development prospects field.

Language: Английский

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Structural and Functional Design of Electrospun Nanofibers for Hemostasis and Wound Healing

Advanced Fiber Materials, Journal Year: 2022, Volume and Issue: 4(5), P. 1027 - 1057

Published: June 30, 2022

Language: Английский

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High-strength hydrogels: Fabrication, reinforcement mechanisms, and applications

Nano Research, Journal Year: 2023, Volume and Issue: 16(2), P. 3475 - 3515

Published: Jan. 3, 2023

Language: Английский

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Supramolecular Thermo‐Contracting Adhesive Hydrogel with Self‐Removability Simultaneously Enhancing Noninvasive Wound Closure and MRSA‐Infected Wound Healing

Advanced Healthcare Materials, Journal Year: 2022, Volume and Issue: 11(13)

Published: April 15, 2022

Conventional wound closure and dressing are two crucial, time-consuming but isolated principles in care. Even though tissue adhesive opens a new era for closure, the method biomaterial that can simultaneously achieve noninvasive promote healing highly appreciated. Herein, novel supramolecular poly(N-isopropylacrylamide) hybrid hydrogel composed of quaternized chitosan-graft-β-cyclodextrin, adenine, polypyrrole nanotubes via host-guest interaction hydrogen bonds is developed. The demonstrates thermal contraction 47% remaining area after 2 h at 37 ℃ adhesion 5.74 kPa, which essential multiple mechanical biological properties including suitable properties, self-healing, on-demand removal, antioxidant, hemostasis, photothermal/intrinsic antibacterial activity (higher 99% killing ratio within 5 min irradiation). In both full-thickness skin incision excision models, reveals significant 24 post-surgery. acute methicillin-resistant Staphylococcus aureus-infected assays, wounds treated with demonstrate enhanced rapid rate, mild inflammatory response, advanced angiogenesis, well-arranged collagen fibers. Altogether, results indicate promising synchronously healing.

Language: Английский

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Military Medical Research, Journal Year: 2023, Volume and Issue: 10(1)

Published: Aug. 22, 2023

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating due to their excellent hydrophilicity, good drug-loading ability sustained drug release properties. As typical example, hyaluronic acid dressing (Healoderm) has been demonstrated clinical trials improve wound-healing efficiency healing rates foot ulcers. However, the degradation behavior clinically-used cannot adjusted according microenvironment. Due intricacy wounds, antibiotics other medications are frequently combined with practice, although these easily hindered by hostile environment. In this case, scientists created responsive-hydrogel based on microenvironment features (such as high glucose low pH) or external stimuli light magnetic field) achieve controllable release, gel degradation, improvements order overcome issues. These anticipated play significant role therapeutic dressings. Here, we review recent advances towards healing, focus structure design, principle responsiveness, degradation. Last but not least, advantages limitations responsive-hydrogels applications will also discussed. We hope contribute furthering progress hydrogels improved practical application.

Language: Английский

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