Sol-Gel/Microemulsion Synthesis of Mesoporous Bioactive Glass Microsphere Using Acetate Precursors: Characterization and Drug Delivery Potential DOI
Seyed Mehdi Razavian, Bijan Eftekhari Yekta, Bijan Eftekhari Yekta

et al.

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130477 - 130477

Published: Jan. 1, 2025

Language: Английский

Microspheres: Preparation Methods, Advances, Applications, and Challenges in Drug Delivery DOI

Krupali Bhalala,

Divyrajsinh Jadeja,

Kiran Dudhat

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

Citations

1
Intracellular Delivery of Itaconate by Metal–Organic Framework-Anchored Hydrogel Microspheres for Osteoarthritis Therapy DOI Creative Commons
Yu Han, Peng Ren, Xuekang Pan

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 724 - 724

Published: Feb. 22, 2023

Treatment of osteoarthritis (OA) remains a significant clinical challenge. Itaconate (IA), an emerging regulator intracellular inflammation and oxidative stress, may potentially be harnessed to treat OA. However, the short joint residence time, inefficient drug delivery, cell-impermeable property IA can seriously hamper translation. Herein, IA-encapsulated zeolitic imidazolate framework-8 (IA-ZIF-8) nanoparticles were self-assembled by zinc ions, 2-methylimidazole, render them pH-responsive. Subsequently, IA-ZIF-8 firmly immobilized in hydrogel microspheres via one-step microfluidic technology. It was demonstrated vitro experiments that IA-ZIF-8-loaded (IA-ZIF-8@HMs) exhibited good anti-inflammatory anti-oxidative stress effects releasing pH-responsive into chondrocytes. Importantly, compared with IA-ZIF-8, IA-ZIF-8@HMs showed better performance treatment OA due their superior sustained release. Thus, such not only hold enormous potential for therapy, but also provide novel avenue drugs constructing appropriate delivery systems.

Language: Английский

Citations

19
Delivery Strategies, Structural Modification, and Pharmacological Mechanisms of Honokiol: A Comprehensive Review DOI

Congying Pan,

Qing Li,

Shuxin Xiong

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(6)

Published: Feb. 3, 2024

Abstract Honokiol (HK) is a traditional Chinese herbal bioactive compound that originates mainly from the Magnolia species , traditionally used to treat anxiety and stroke, as well alleviation of flu symptoms. This natural product its derivatives displayed diverse biological activities, including anticancer, antioxidant, anti‐inflammatory, neuroprotective, antimicrobial activities. However, poor bioavailability pharmacological activity require primary consideration in development HK‐based drugs. Recent innovative HK formulations based on nanotechnology approach allowed for improvement both therapeutic efficacy. Chemical derivation drug combination are also effective strategies ameliorate drawbacks HK. In recent years, studies compositions have made great progress treatment cancer, inflammation, bacterial infection, cardiovascular, cerebrovascular diseases, demonstrating better than The objective this review an examination developments field drug‐related issues, approaches improve physicochemical properties, solubility, stability, bioavailability. patents ongoing clinical trials summarized.

Language: Английский

Citations

8
Recent advances in targeted therapy for inflammatory vascular diseases DOI
Kaiwen Zhao, Zan Zeng,

Yuzhen He

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 372, P. 730 - 750

Published: July 3, 2024

Language: Английский

Citations

8
Unveiling the antimicrobial potency and binding interaction between sulfonamide substituted Schiff’s bases and BSA protein: An integrated experimental and theoretical approach DOI

Ankita Garg,

Anjali Vijeata,

Ganga Ram Chaudhary

et al.

Journal of Molecular Liquids, Journal Year: 2024, Volume and Issue: 401, P. 124710 - 124710

Published: April 9, 2024

Language: Английский

Citations

7
Preparation of gelatin-starch shell-yolk microspheres by water-in-water emulsion method: Effects of starch crystal type and cross-linking DOI
Zhirenyong Zhang,

Xiaoxue He,

Ting Yan

et al.

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 154, P. 110134 - 110134

Published: April 25, 2024

Language: Английский

Citations

7
Natural Materials for 3D Printing and Their Applications DOI Creative Commons
Chunyu Su, Yutong Chen,

Shujing Tian

et al.

Gels, Journal Year: 2022, Volume and Issue: 8(11), P. 748 - 748

Published: Nov. 17, 2022

In recent years, 3D printing has gradually become a well-known new topic and research hotspot. At the same time, advent of is inseparable from preparation bio-ink. Natural materials have advantages low toxicity or even non-toxicity, there being abundant raw materials, easy processing modification, excellent mechanical properties, good biocompatibility, high cell activity, making them very suitable for With help technology, prepared scaffolds can be widely used in tissue engineering other fields. Firstly, we introduce natural their properties summarize physical chemical these applications after modification. Secondly, discuss modification methods including physical, chemical, protein self-assembly methods. We also method printing. Then, application engineering, skin tissue, cartilage bone vascular tissue. Finally, express some views on materials.

Language: Английский

Citations

28
Glycosaminoglycans’ Ability to Promote Wound Healing: From Native Living Macromolecules to Artificial Biomaterials DOI Creative Commons
Peng Yang, Yifei Lü,

Weiming Gou

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 11(9)

Published: Dec. 10, 2023

Abstract Glycosaminoglycans (GAGs) are important for the occurrence of signaling molecules and maintenance microenvironment within extracellular matrix (ECM) in living tissues. GAGs GAG‐based biomaterial approaches have been widely explored to promote situ tissue regeneration repair by regulating wound microenvironment, accelerating re‐epithelialization, controlling ECM remodeling. However, most remain unacceptable clinical applications. To improve insights into material design translational applications, this review highlights innate roles bioactive mechanisms native during healing presents common biomaterials adaptability application scenarios facilitating healing. Furthermore, challenges before widespread commercialization shared, ensure that future designed constructed artificial more likely recapitulate unique tissue‐specific profile GAG expression human This provides a explicit clear selection guide researchers designing biomimetic materials, which will resemble or exceed their natural counterparts certain functions, thereby suiting specific environments therapeutic goals.

Language: Английский

Citations

13
Uncover the anticancer potential of lycorine DOI Creative Commons
Yanming Zhang, Ting Li,

Chun-Cao Xu

et al.

Chinese Medicine, Journal Year: 2024, Volume and Issue: 19(1)

Published: Sept. 8, 2024

Language: Английский

Citations

4
A biphasic drug-releasing microneedle with ROS scavenging and angiogenesis for the treatment of diabetic ulcers DOI
Xinyue He,

Lianghong Peng,

Liming Zhou

et al.

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

4