Tissue Engineering for Penile Reconstruction

Bioengineering, Journal Year: 2024, Volume and Issue: 11(3), P. 230 - 230

Published: Feb. 28, 2024

The penis is a complex organ with development cycle from the fetal stage to puberty. In addition, it may suffer either congenital or acquired anomalies. Penile surgical reconstruction has been center of interest for many researchers but still challenging due complexity its anatomy and functionality. this review, penile anatomy, pathologies, current treatments are described, including techniques tissue engineering approaches. self-assembly technique currently applied emphasized since considered promising an adequate tissue-engineered reconstructed substitute.

Language: Английский

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Dynamic 3D in vitro lung models: applications of inorganic nanoparticles for model development and characterization

Nanoscale, Journal Year: 2024, Volume and Issue: 16(23), P. 10880 - 10900

Published: Jan. 1, 2024

Being a vital organ exposed to the external environment, lung is susceptible plethora of pathogens and pollutants. This reflected in high incidences chronic respiratory diseases, which remain leading cause mortality world-wide pose persistent global burden. It thus paramount importance improve our understanding these pathologies provide better therapeutic options. necessitates development representative physiologically relevant vitro models. Advances bioengineering have enabled sophisticated models that not only capture three-dimensional architecture cellular environment but also incorporate dynamics local biophysical stimuli. However, such complex require novel approaches reliable characterization. Within this review we explore how 3D bioprinting nanoparticles can serve as multifaceted tools develop dynamic 4D printed facilitate their characterization context pulmonary fibrosis breast cancer metastasis.

Language: Английский

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Decellularized tissues as platforms for digestive system cancer models

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e31589 - e31589

Published: May 21, 2024

The extracellular matrix (ECM) is a multifunctional network of macromolecules that regulate various cellular functions and physically support the tissues. Besides physiological conditions, ECM also changes during pathological conditions such as cancer. As tumor cells proliferate, notable occur in quantity makeup surrounding ECM. Therefore, role this noncellular component tissues studies microenvironments should be considered. So far, many attempts have been made to create 2-dimensional (2D) or 3-dimensional (3D) models can replicate intricate connections within microenvironment. Decellularized are proper scaffolds imitate complex nature native This review aims summarize 3D digestive system cancers based on decellularized ECMs. These ECM-based will enable us study interactive communication between their environment which brings new potential for better understanding pathophysiology

Language: Английский

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Composite bioink incorporating cell-laden liver decellularized extracellular matrix for bioprinting of scaffolds for bone tissue engineering

Biomaterials Advances, Journal Year: 2024, Volume and Issue: 165, P. 214017 - 214017

Published: Aug. 30, 2024

The field of bone tissue engineering (BTE) has witnessed a revolutionary breakthrough with the advent three-dimensional (3D) bioprinting technology, which is considered an ideal choice for constructing scaffolds regeneration. key to realizing scaffold biofunctions selection and design appropriate bioink, existing bioinks have significant limitations. In this study, composite bioink based on natural polymers (gelatin alginate) liver decellularized extracellular matrix (LdECM) was developed used fabricate BTE using 3D bioprinting. Through in vitro studies, concentration LdECM incorporated into optimized achieve printability stability improve proliferation osteogenic differentiation loaded rat mesenchymal stem cells (rBMSCs). Furthermore, vivo experiments were conducted Sprague Dawley model critical-sized calvarial defects. proposed rBMSC-laden LdECM-gelatin-alginate scaffold, bioprinted layer-by-layer, implanted defect development new growth studied four weeks. findings showed that bioactive facilitated angiogenesis osteogenesis at site. study suggest great potential clinical translation application solving regeneration problems.

Language: Английский

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Decellularized Macroalgae as Complex Hydrophilic Structures for Skin Tissue Engineering and Drug Delivery

Gels, Journal Year: 2024, Volume and Issue: 10(11), P. 704 - 704

Published: Oct. 31, 2024

Due to their indisputable biocompatibility and abundant source, biopolymers are widely used prepare hydrogels for skin tissue engineering. Among them, cellulose is a great option this challenging application due its increased water retention capacity, mechanical strength, versatility unlimited availability. Since algae an unexploited source of cellulose, the novelty study decellularization two different species, freshly collected from Black Sea coast, using chemical surfactants (sodium dodecyl sulphate Triton X-100), characterisation resulted complex biopolymeric 3D matrices. The nature agent significantly influenced matrices porosity, while values obtained hydration degree included them in hydrogel class. Moreover, capacity retain then controllably release anti-inflammatory drug, ibuprofen, led us recommend structures as drug delivery systems. decellularized macroalgae bioadhesive cytocompatible direct contact with human keratinocytes represent support cells. Finally, it was noticed that (HaCaT cell line) adhered populated during monitoring period 14 days.

Language: Английский

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