Deleted Journal,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 29, 2024
In
recent
years,
injectable
cryogels
have
been
frequently
used
in
various
biomedical
applications
such
as
tissue
engineering,
drug
delivery,
therapeutics,
therapy,
cell
transplantation
and
immunotherapy.
Cryogels,
one
of
the
biomaterials
with
3D
scaffold
structures,
important
properties
biocompatibility,
physical
resistance,
macropore
sensitivity.
addition
to
being
biocompatible,
cryogels,
consisting
three-dimensional
(3D)
scaffolds
physicochemical
elasticity,
hardness
biological
degradation,
provide
a
structural
support
environment
for
development
along
attachment.
addition,
can
be
loaded
therapeutic
agents
or
cells
engineering
clinical
studies.
The
purpose
this
review
is
explain
chemical
scaffolding,
after
explaining
synthesis
stages
it
thought
guide
make
their
use
different
areas
more
widespread
future
Small Science,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 25, 2024
The
genetic
material
within
cells
plays
a
pivotal
role
in
shaping
the
structure
and
function
of
living
organisms.
Manipulating
an
organism's
genome
to
correct
inherited
abnormalities
or
introduce
new
traits
holds
great
promise.
Genetic
engineering
techniques
offers
promising
pathways
for
precisely
altering
cellular
genetics.
Among
these
methodologies,
clustered
regularly
interspaced
short
palindromic
repeat
(CRISPR),
honored
with
2020
Nobel
Prize
Chemistry,
has
garnered
significant
attention
its
precision
editing
genomes.
However,
CRISPR
system
faces
challenges
when
applied
vivo,
including
low
delivery
efficiency,
off-target
effects,
instability.
To
address
challenges,
innovative
technologies
targeted
precise
have
emerged.
Engineered
carrier
platforms
represent
substantial
advancement,
improving
stability,
precision,
reducing
side
effects
associated
editing.
These
facilitate
efficient
local
systemic
various
tissues
cells,
immune
cells.
This
review
explores
recent
advances,
benefits,
CRISPR-based
delivery.
It
examines
carriers
nanocarriers
(polymeric,
lipid-derived,
metallic,
bionanoparticles),
viral
particles,
virus-like
exosomes,
providing
insights
into
their
clinical
utility
future
prospects.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 15, 2024
Heart
failure
is
a
major
health
problem
in
which
the
heart
unable
to
pump
enough
blood
meet
body’s
needs.
It
progressive
disease
that
becomes
more
severe
over
time
and
can
be
caused
by
variety
of
factors,
including
attack,
cardiomyopathy
valve
disease.
There
are
various
methods
cure
this
disease,
has
many
complications
risks.
The
advancement
knowledge
technology
proposed
new
for
diseases.
One
promising
treatments
tissue
engineering.
Tissue
engineering
field
research
aims
create
living
tissues
organs
replace
damaged
or
diseased
tissue.
goal
improve
cardiac
function
reduce
need
transplantation.
This
done
using
three
important
principles
cells,
biomaterials
signals
techniques
cells
such
as
electrospinning,
hydrogel
synthesis,
decellularization,
etc.
diverse.
Treating
through
still
under
development
research,
but
it
hoped
there
will
no
transplants
invasive
surgeries
near
future.
In
study,
based
on
most
recent
years,
we
examine
power
treatment
failure.
Cancer Communications,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 3, 2025
Abstract
Despite
significant
advancements
in
cancer
treatment,
current
therapies
often
fail
to
completely
eradicate
malignant
cells.
This
shortfall
underscores
the
urgent
need
explore
alternative
approaches
such
as
vaccines.
Leveraging
immune
system's
natural
ability
target
and
kill
cells
holds
great
therapeutic
potential.
However,
development
of
vaccines
is
hindered
by
several
challenges,
including
low
stability,
inadequate
response
activation,
immunosuppressive
tumor
microenvironment,
which
limit
their
efficacy.
Recent
progress
various
fields,
click
chemistry,
nanotechnology,
exosome
engineering,
neoantigen
design,
offer
innovative
solutions
these
challenges.
These
achievements
have
led
emergence
smart
vaccine
platforms
(SVPs),
integrate
protective
carriers
for
messenger
ribonucleic
acid
(mRNA)
with
functionalization
strategies
optimize
targeted
delivery.
Click
chemistry
further
enhances
SVP
performance
improving
encapsulation
mRNA
antigens
facilitating
precise
delivery
review
highlights
latest
developments
technologies
therapy,
exploring
both
opportunities
challenges
advancing
transformative
approaches.
Frontiers in Biomaterials Science,
Journal Year:
2023,
Volume and Issue:
2
Published: Nov. 10, 2023
Biomaterials
undergo
a
transformative
journey,
from
their
origin
as
renewable
resources
to
the
manufacturing
plants
where
they
are
processed
and
stored,
until
fulfill
intended
therapeutic
or
diagnostic
purposes
become
medical
waste.
However,
during
this
life
cycle,
biomaterials
can
be
susceptible
contamination
subsequent
degradation
through
various
mechanisms
such
hydro-mechanical,
thermal,
biochemical
processes
in
water,
soil,
air.
These
factors
raise
significant
concerns
regarding
biological
safety.
Additional
complexities
arise
potential
amalgamation
of
with
other
materials,
either
same
kind
different
types.
Use
influences
porosity,
surface
chemistry,
structural
strength,
these
affect
biomaterials’
reusability.
Given
multitude
processing
parameters,
sustainability
requirements,
limitation
natural
resources,
recycling
becomes
necessary.
Unfortunately,
topic
has
received
limited
attention
thus
far.
In
context,
perspective
provides
brief
overview,
analysis,
classification
reports
on
recycling,
aiming
initiate
discussion
frequently
overlooked
subject.
We
highlight
challenges
related
energy
consumption
environmental
pollution.
lack
established
protocols
reporting
prevents
comprehensive
understanding
solutions.
Nevertheless,
addressing
issues
lead
more
efficient
resource
use
reduced
impact
field
biomaterials.
