Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(14), P. 15753 - 15767
Published: March 26, 2024
Tumors
are
one
of
the
main
diseases
threatening
human
life
and
health.
The
emergence
nanotechnology
in
recent
years
has
introduced
a
novel
therapeutic
avenue
for
addressing
tumors.
Through
amalgamation
nanotechnology's
inherent
attributes
with
those
natural
enzymes,
nanozymes
have
demonstrated
ability
to
initiate
catalytic
reactions,
modulate
biological
microenvironment,
facilitate
adoption
multifaceted
approaches,
thereby
exhibiting
considerable
promise
realm
cancer
treatment.
In
this
Review,
application
chemodynamic
therapy,
radiotherapy,
photodynamic
photothermal
starvation
therapy
summarized.
Moreover,
detailed
discussion
regarding
mechanism
conferring
physiotherapeutic
functionality
upon
nanosystems
is
provided.
It
posited
that
innovative
treatment
holds
significant
potential
play
crucial
role
within
domain
nanomedicine.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 9, 2024
The
field
of
oncology
has
transformed
in
recent
years,
with
treatments
shifting
from
traditional
surgical
resection
and
radiation
therapy
to
more
diverse
customized
approaches,
one
which
is
immunotherapy.
ICD
(immunogenic
cell
death)
belongs
a
class
regulatory
death
modalities
that
reactivate
the
immune
response
by
facilitating
interaction
between
apoptotic
cells
releasing
specific
signaling
molecules,
DAMPs
(damage-associated
molecular
patterns).
inducers
can
elevate
expression
proteins
optimize
TME
(tumor
microenvironment).
use
nanotechnology
shown
its
unique
potential.
Nanomaterials,
due
their
tunability,
targeting,
biocompatibility,
have
become
powerful
tools
for
drug
delivery,
immunomodulators,
etc.,
significant
efficacy
clinical
trials.
In
particular,
these
nanomaterials
effectively
activate
ICD,
trigger
potent
anti-tumor
response,
maintain
long-term
tumor
suppression.
Different
types
nanomaterials,
such
as
biological
membrane-modified
nanoparticles,
self-assembled
nanostructures,
metallic
mesoporous
materials,
hydrogels,
play
respective
roles
induction
structures
mechanisms
action.
Therefore,
this
review
will
explore
latest
advances
application
common
discuss
how
they
provide
new
strategies
cancer
therapy.
By
gaining
deeper
understanding
mechanism
action
researchers
develop
precise
effective
therapeutic
approaches
improve
prognosis
quality
life
patients.
Moreover,
hold
promise
overcome
resistance
conventional
therapies,
minimize
side
effects,
lead
personalized
treatment
regimens,
ultimately
benefiting
treatment.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: April 18, 2024
Abstract
Androgen
deprivation
therapy
(ADT)
is
a
crucial
and
effective
strategy
for
prostate
cancer,
while
systemic
administration
may
cause
profound
side
effects
on
normal
tissues.
More
importantly,
the
ADT
can
easily
lead
to
resistance
by
involving
activation
of
NF-κB
signaling
pathway
high
infiltration
M2
macrophages
in
tumor
microenvironment
(TME).
Herein,
we
developed
biomimetic
nanotherapeutic
platform
deriving
cell
membrane
nanovesicles
from
cancer
cells
probiotics
yield
hybrid
cellular
(hNVs),
loading
flutamide
(Flu)
into
resulting
hNVs,
finally
modifying
hNVs@Flu
with
Epigallocatechin-3-gallate
(EGCG).
In
this
platform,
hNVs
significantly
improved
accumulation
hNVs@Flu-EGCG
sites
reprogramed
immunosuppressive
antitumorigenic
M1
macrophages,
Flu
acted
androgen
receptors
inhibited
proliferation,
EGCG
promoted
apoptosis
inhibiting
pathway,
thus
synergistically
stimulating
antitumor
immunity
reducing
ADT.
mouse
model,
extended
lifespan
mice
tumors
led
an
81.78%
reduction
growth
compared
untreated
group.
Overall,
are
safe,
modifiable,
effective,
offering
promising
therapeutics
cancer.
Graphical
Nanoscale Advances,
Journal Year:
2024,
Volume and Issue:
6(17), P. 4275 - 4308
Published: Jan. 1, 2024
Chemotherapy
and
surgery
remain
the
primary
treatment
modalities
for
cancers;
however,
these
techniques
have
drawbacks,
such
as
cancer
recurrence
toxic
side
effects,
necessitating
more
efficient
strategies.
Recent
advancements
in
research
medical
technology
provided
novel
insights
expanded
our
understanding
of
development;
consequently,
scholars
investigated
several
delivery
vehicles
therapy
to
improve
efficiency
patient
outcomes.
Herein,
we
summarize
types
smart
therapeutic
carriers
elaborate
on
mechanism
underlying
drug
delivery.
We
reveal
advantages
treatment,
focus
their
effectiveness
immunotherapy,
discuss
application
combination
with
other
emerging
strategies
treatment.
Finally,
bottlenecks
encountered
development
suggest
directions
future
research.
This
review
will
promote
progress
facilitate
related
