Design and application of antimicrobial nanomaterials in the treatment of periodontitis

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17

Published: March 5, 2025

Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy scaling root planning periodontitis promising strategy. However, this administration method's effectiveness constrained complexity environment. Nanomaterials have demonstrated significant potential antibacterial treatment periodontitis, attributed their controllable size, shape, surface charge, high design flexibility, reactivity, specific area. In review, we summarize complex microenvironment difficulties explicitly reviewing application strategies nanomaterials with unique properties distinct periodontitis. Furthermore, review discusses limitations current research, proposes feasible solutions, explores prospects for using context.

Language: Английский

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Antimicrobial Biomaterial for Dental Healthcare Application

Published: Jan. 1, 2025

Language: Английский

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Antibacterial Ceramics for Dental Applications

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(8), P. 4553 - 4553

Published: April 21, 2025

Background: The aim of this review was to evaluate the antibacterial properties functionalized bioceramics for dental applications. Methods: electronic databases PubMed, Medline, ProQuest, and Google Scholar were used search peer-reviewed scientific publications published between 2020 2025 that provide insights answer research questions related role antibacterial-functionalized in combating pathogens dentistry without triggering immune reactions inflammation, as well on their efficacy against various whether understanding mechanism can promote development glass-ceramic bioceramic with long-term activity. keywords were: bioglass, bioceramic, biocompatible, antibacterial, osseointegration, implant, bioactive materials. Results: Bacterial infections play a key longevity medical devices. A crucial problem is drug-resistant bacteria. Antibacterial ceramics have received great attention recently because activity, good mechanical properties, biocompatibility, bioactivity. This provides detailed examination complex interactions bacteria, cells, from clinical perspective. focus researchers developing new-generation multifunctionality, particular are independent conventional antibiotics. highlight exploration dual functions such promoting bone regeneration which potential revolutionize implant technology. Another modifying surface hydrophilic hydrophobic order increase activity bioceramics. Conclusions: help understand current state-of-the-art activities bioceramics, could application.

Language: Английский

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Dual role of zinc oxide nanoparticles in antifungal action against Rhizoctonia solani, biosafety and phytotoxicity concerns in crop plants

Physiological and Molecular Plant Pathology, Journal Year: 2025, Volume and Issue: unknown, P. 102712 - 102712

Published: April 1, 2025

Language: Английский

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An Overview of Dental Solid Waste Management and Associated Environmental Impacts: A Materials Perspective

Sustainability, Journal Year: 2023, Volume and Issue: 15(22), P. 15953 - 15953

Published: Nov. 15, 2023

Dental healthcare plays an important role in the overall health of individuals, and sector is rapidly growing around world due to increases population, facilities, improved access for economically weaker sections society. procedures oral care generate a significant amount biomedical waste that should be managed environmentally safe sustainable manner. An overview presented current status dental solid management with focus on composition from traditional emerging treatments, new-generation materials, treatment procedures, options. can broadly divided into three categories: infectious waste, non-infectious domestic-type waste. Infectious contains materials contaminated blood or other mouth fluids, amalgam, sharps, whereas devoid human fluid contamination but potentially toxic presence amalgams, acids, metal dust, resins, etc. Suspended particulates wastewater are another likely source contamination. Appropriate segregation this essential containing infections during processing. New-generation such as nanomaterials, resin-based composites, ceramics, finding increasing applications variety antimicrobial, restorative, therapeutic agents. While incineration landfilling have been used processing novel raises several additional concerns. Novel single/multistage recycling approaches need developed towards resource recovery, thus minimizing extent possible.

Language: Английский

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Chemical Modification of Dental Dimethacrylate Copolymer with Tetramethylxylylene Diisocyanate-Based Quaternary Ammonium Urethane-Dimethacrylates—Physicochemical, Mechanical, and Antibacterial Properties

Materials, Journal Year: 2024, Volume and Issue: 17(2), P. 298 - 298

Published: Jan. 7, 2024

In this study, two novel quaternary ammonium urethane-dimethacrylates (QAUDMAs) were designed for potential use as comonomers in antibacterial dental composite restorative materials. QAUDMAs synthesized via the reaction of 1,3-bis(1-isocyanato-1-methylethyl)benzene with 2-(methacryloyloxy)ethyl-2-decylhydroxyethylmethylammonium bromide (QA10+TMXDI) and 2-(methacryloyloxy)ethyl-2-dodecylhydroxyethylmethylammonium (QA12+TMXDI). Their compositions common dimethacrylates comprising QAUDMA 20 wt.%, urethane-dimethacrylate monomer (UDMA) bisphenol A glycerolate dimethacrylate (Bis-GMA) 40 triethylene glycol (TEGDMA) photocured. The achieved copolymers characterized their physicochemical mechanical properties, including degree conversion (DC), glass transition temperature (Tg), polymerization shrinkage (S), water contact angle (WCA), flexural modulus (E), strength (FS), hardness (HB), sorption (WS), leachability (WL). activity was by minimum bactericidal concentration (MBC) inhibitory (MIC) against Staphylococcus aureus Escherichia coli. results compared to properties a typical copolymer UDMA Bis-GMA TEGDMA wt.%. introduction did not deteriorate properties. WS WL increased; however, they still satisfactory. QA10+TMXDI showed higher effect than that QA12+TMXDI reference copolymer.

Language: Английский

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Mechanophysical and Anti-Adhesive Properties of a Nanoclay-Containing PMMA Denture Resin

ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(4), P. 2151 - 2164

Published: March 7, 2024

Poly(methyl methacrylate) (PMMA) is commonly used for dental dentures, but it has the drawback of promoting oral health risks due to bacterial adhesion. Recently, various nanoparticles have been incorporated into PMMA tackle these issues. This study aims investigate mechanophysical and antimicrobial adhesive properties a denture resin by incorporating nanoclay PMMA. Specimens were prepared adding 0, 1, 2, 4 wt % surface-modified (Sigma) self-polymerizing resin. These specimens then evaluated using FTIR, TGA/DTG, FE-SEM with EDS. Various mechanical surface physical properties, including nanoindentation, measured compared those pure Antiadhesion experiments conducted applying Candida albicans (ATCC 11006) suspension specimens. The antiadhesion activity C. was confirmed through yeast-wall component (mannan) mRNA-seq analysis. bulk nanoclay-PMMA composites decreased PMMA, while flexural strength modulus met ISO 20795-1 requirement. However, there no significant differences in nanoindentation hardness elastic modulus. energy revealed decrease at nanoclay-PMMA. effect evident along content nanocomposites reduced attachment mannan on composites. analysis supported overall transcriptome changes altering metabolism behaviors surface. materials showed lower as increased, leading an against albicans. findings indicate that surfaces could be valuable strategy preventing fungal biofilm formation base materials.

Language: Английский

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Bio-based Nanomaterials in Dentistry

Published: Jan. 1, 2024

This chapter will look at the big picture of bio-based nanomaterials in dentistry, discussing their types, applications, advantages, challenges, and potential solutions. Bio-based have generated considerable interest dentistry due to superior physical qualities, increased biocompatibility, for targeted drug delivery. Various nanomaterials, including nanoparticles, nanofibers, nanocomposites, are explored restorative preventive endodontics, dental implants. These materials offer promising alternatives traditional materials, with applications ranging from antibacterial agents remineralizing biocompatible implants endodontic sealers. Despite several challenges need be addressed, such as cytotoxicity, regulatory hurdles, cost scalability production. The highlights future research directions, development novel exploration new advancements nanofabrication techniques, integration digital dentistry. Furthermore, addressing safety concerns improving biocompatibility crucial successfully implementing practice. continued this field revolutionize offering improved treatment options overall patient care.

Language: Английский

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Antibiotic Alternatives: Multifunctional Ultra-Small Metal Nanoclusters for Bacterial Infectious Therapy Application

Molecules, Journal Year: 2024, Volume and Issue: 29(13), P. 3117 - 3117

Published: June 30, 2024

The prevalence of major bacterial infections has emerged as a significant menace to human health and life. Conventional treatment methods primarily rely on antibiotic therapy, but the overuse these drugs led decline in their efficacy. Moreover, bacteria have developed resistance towards antibiotics, giving rise emergence superbugs. Consequently, there is an urgent need for novel antibacterial agents or alternative strategies combat infections. Nanoantibiotics encompass class nano-antibacterial materials that possess inherent antimicrobial activity can serve carriers enhance drug delivery efficiency safety. In recent years, metal nanoclusters (M NCs) gained prominence field nanoantibiotics due ultra-small size (less than 3 nm) distinctive electronic optical properties, well biosafety features. this review, we discuss progress M NCs new generation agents. First, main synthesis characteristics are presented. Then, focus reviewing various detecting treating pathogenic using NCs, summarizing effects wound infections, biofilms, oral Finally, propose perspective remaining challenges future developments infectious therapy.

Language: Английский

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Nanozymes: a promising solution for dental antibacterial applications

RSC Advances, Journal Year: 2024, Volume and Issue: 14(50), P. 36945 - 36959

Published: Jan. 1, 2024

This review analyzes nanozyme classification, mechanisms, and emerging applications, shedding light on their potential to revolutionize dental antibacterial treatments addressing current challenges future perspectives in development.

Language: Английский

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