Published: Jan. 1, 2024
Language: Английский
European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117357 - 117357
Published: Feb. 5, 2025
Language: Английский
Citations
6
Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(1), P. 4 - 4
Published: Jan. 31, 2025
Regrettably, despite undeniable advances in cancer diagnosis and therapy, primary brain (or cancer) remains one of the deadliest forms malignant tumors, where glioblastoma (GBM) is known as most diffuse glioma astrocytic lineage. Fortunately, to improve this scenario, remarkable progress nanotechnology has brought new promise raised expectations treatment. Nanomedicine, principally an area amalgamating with biology medicine, demonstrated a pivotal role, starting earliest detection while also offering novel multimodal therapy alternatives. In vast realm nanotechnology, nanozymes, type nanomaterial intrinsic enzyme-like activities characteristics connecting fields nanocatalysts, enzymology, biology, have emerged powerful nanotools for theranostics. Hence, fascinating field research experienced exponential growth recent years. As it virtually impossible cover all literature on broad domain science paper, review focuses presenting multidisciplinary approach, its content extending from fundamental knowledge nanozymes enzyme-mimicking catalysis targeting cancers. Although we are at very early stages research, can be envisioned that strategic development theranostics will positively offer disruptive nanoplatforms future nano-oncology.
Language: Английский
Citations
2
Biomaterials Science, Journal Year: 2024, Volume and Issue: 12(6), P. 1346 - 1356
Published: Jan. 1, 2024
Blood–brain barrier-crossing dendrimers for glioma imaging diagnostics, chemotherapy, gene therapy, or imaging-guided therapy have been concisely reviewed with perspectives briefly discussed.
Language: Английский
Citations
10
International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 6757 - 6776
Published: July 1, 2024
Abstract: Glioma is a primary malignant tumor in the central nervous system. In recent years, treatment of glioma has developed rapidly, but overall survival patients not significantly improved. Due to presence blood–brain barrier and intracranial barrier, many drugs with good effects cure vitro cannot be accurately transported corresponding lesions. order enable anti-tumor overcome barriers target glioma, nanodrug delivery systems have emerged recently. It gratifying that liposomes, as multifunctional carrier, which can compatible hydrophilic hydrophobic drugs, easily functionalized by various targeted ligands, biodegradable, hypoimmunogenic vivo, become quality choice solve intractable problem medication. Therefore, we focused on liposome system, summarized its current research progress glioma. Hopefully, this review may provide new ideas for development liposome-based nanomaterials clinical Keywords: blood‒brain nanomaterials, liposome, nanoparticle drug system
Language: Английский
Citations
5
Journal of Cellular and Molecular Medicine, Journal Year: 2025, Volume and Issue: 29(4)
Published: Feb. 1, 2025
ABSTRACT Gliomas are the most ordinary primary virulent brain tumours and commonly used clinical treatments include tumour resection, radiation therapy chemotherapy. Although significant progress has been made in recent years progression‐free survival (PFS) overall (OS) for patients with high‐grade gliomas, prognosis remains poor. Chemoresistance refers to phenomenon of decreased sensitivity cells drugs, resulting reduced or ineffective drug efficacy, is an important cause failure Exosomes, a type extracellular vesicle, secreted by cancer various stromal microenvironment (TME) transfer their inclusions cells, increasing chemoresistance. Furthermore, depletion exosomes reverses certain detrimental effects on metabolism restores chemotherapeutic agents. Here, we summarised correlation between resistance agents glioma patients, mechanisms action involved value. We aimed afford new thoughts research, diagnosis intervention chemoresistance patients.
Language: Английский
Citations
0
Biomaterials Research, Journal Year: 2025, Volume and Issue: 29
Published: Jan. 1, 2025
Tumors are the second most common cause of mortality globally, ranking just below heart disease. With continuous advances in diagnostic technology and treatment approaches, survival rates some cancers have increased. Nevertheless, due to complexity mechanisms underlying tumors, cancer remains a serious public health issue that threatens population globally. Manganese (Mn) is an essential trace element for human body. Its regulatory role tumor biology has received much attention recent years. Developments nanotechnology led emergence Mn-based nanoparticles great potential use diagnosis cancers. nanomaterials can be integrated with conventional techniques, including chemotherapy, radiation therapy, gene augment their therapeutic effectiveness. Further, play synergistic emerging strategies such as immunotherapy, photothermal photodynamic electromagnetic hyperthermia, sonodynamic chemodynamic intervention therapy. Moreover, enhance both precision diagnostics capability combined treatment. This article examines roles associated Mn field physiology biology, focus on application prospects
Language: Английский
Citations
0
Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown
Published: April 21, 2025
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2024, Volume and Issue: 26(8)
Published: Aug. 1, 2024
Abstract Glioblastoma (GBM), the most prevalent primary brain tumor in adults, remains highly challenging due to its invasive nature, limited treatment effectiveness, and short median survival durations. Standard of care includes surgery, radiation, chemotherapy, treating fields; however, there has been little improvement rates. Biomimetic nanoparticles (NPs), coated with cell membranes endogenous components, have immense potential for improving chemotherapy GBM, by imitating cellular architecture eluding immune clearance. With more individualized efficient drug delivery, immunotherapeutic approaches biomimetic NPs may increase patient This article summarizes main research on GBM therapy, focusing classification, mechanisms, advantages, challenges, along advancements development vaccines.
Language: Английский
Citations
3
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 15, 2025
Abstract Brain cancer remains a significant challenge in the field of oncology, primarily because its aggressive nature and limited treatment options available. Conventional therapies often fall short effectively targeting tumor cells, while sparing healthy brain tissue from collateral damage. However, exosomes are now recognized as promising nanocarriers for targeted drug delivery. These naturally occurring extracellular vesicles can cross blood–brain barrier selectively interact with cells. Utilizing delivery vehicles offers novel approach potential therapy. By encapsulating therapeutic agents within exosomes, drugs be specifically to maximizing their impact whilst minimizing damage tissue. Furthermore, modified display molecules that recognize bind further enhancing precision efficacy. While exosome-based show potential, scalability, purification, clinical application challenges remain. The scalability exosome production, modification techniques hurdle must overcome translation. Additionally, intricate interactions between microenvironment necessitate research optimize outcomes. review explores applications future perspectives advancing treatment.
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 5779 - 5797
Published: May 1, 2025
Language: Английский
Citations
0