Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide DOI Creative Commons
Lei Wang, Xiao Liu,

Yiliang Wu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4223 - 4223

Published: Sept. 5, 2024

Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has potential for drug delivery. However, alteration of CSSC dihedral angle induced by different substituents directly affects effectiveness this its stability. Previously, we constructed a trivalent low that can effectively promote cellular uptake small molecules. Here, novel unit-masked oligonucleotide hybrid unit, motivated prodrug design. Cellular imaging results showed such system exhibited superior efficiency than commercial Lipo2000 without cytotoxicity. The reagents significantly reduced (57–74%), which proved to be endocytosis-independent. In addition, vivo distribution experiments mice rapidly distributed liver tissues with duration action more 24 h, representing means silencing genes involved pathogenesis liver-like diseases. conclusion, deliver large drugs.

Language: Английский

Lipidic and Inorganic Nanoparticles for Targeted Glioblastoma Multiforme Therapy: Advances and Strategies DOI Creative Commons
Ewelina Musielak, Violetta Krajka‐Kuźniak

Micro, Journal Year: 2025, Volume and Issue: 5(1), P. 2 - 2

Published: Jan. 3, 2025

Due to their biocompatibility, nontoxicity, and surface conjugation properties, nanomaterials are effective nanocarriers capable of encapsulating chemotherapeutic drugs facilitating targeted delivery across the blood–brain barrier (BBB). Although research on nanoparticles for brain cancer treatment is still in its early stages, these systems hold great potential revolutionize drug delivery. Glioblastoma multiforme (GBM) one most common lethal tumors, heterogeneous aggressive nature complicates current treatments, which primarily rely surgery. One significant obstacles poor penetration BBB. Moreover, GBM often referred as a “cold” tumor, characterized by an immunosuppressive tumor microenvironment (TME) minimal immune cell infiltration, limits effectiveness immunotherapies. Therefore, developing novel, more treatments critical improving survival rate patients. Current strategies enhancing outcomes focus controlled, agents cells BBB using nanoparticles. These therapies must be designed engage specialized transport systems, allowing efficient penetration, improved therapeutic efficacy, reduced systemic toxicity degradation. Lipid inorganic can enhance while minimizing side effects. formulations may include epitopes—small antigen fragments that bind directly free antibodies, B receptors, or T receptors—that interact with enable crossing, thereby boosting efficacy. Lipid-based (LNPs), such liposomes, niosomes, solid lipid (SLNs), nanostructured carriers (NLCs), among promising due unique including size, modification capabilities, proven biosafety. Additionally, gold nanoparticles, mesoporous silica, superparamagnetic iron oxide dendrimers offer alternatives. Inorganic (INPs) easily engineered, surfaces modified various elements biological ligands delivery, biocompatibility. Strategies engineering functionalization have been employed ensure biocompatibility reduce cytotoxicity, making safer clinical applications. The use INPs has shown promise efficacy traditional like chemotherapy, radiotherapy, gene therapy, well advancing newer strategies, immunotherapy, photothermal photodynamic therapies, magnetic hyperthermia. This article reviews latest treating GBM, focusing active passive targeting approaches.

Language: Английский

Citations

3
Progress in Drug Delivery Systems Based on Nanoparticles for Improved Glioblastoma Therapy: Addressing Challenges and Investigating Opportunities DOI Open Access
Md. Ataur Rahman, Maroua Jalouli,

Mahesh Kumar Yadab

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 701 - 701

Published: Feb. 19, 2025

Glioblastoma multiforme (GBM) is a highly malignant brain tumor that has bleak outlook despite existing treatments such as surgery, radiation, and chemotherapy. The utilization of nanoparticles for drug delivery presents promising method by which to improve the effectiveness treatment while reducing harmful effects on entire body. This review examines application in GBM, focusing different types nanoparticles, including lipid-based, polymeric, metallic, those under development. Every variety analyzed its distinct characteristics therapeutic capacity. Lipid-based liposomes solid lipid enhance transport medicines are not soluble water have shown considerable potential preclinical investigations. Polymeric benefits terms controlled release targeted distribution, whereas metallic both therapy imaging. In current we would like emphasize ways medicine delivery, specifically enhancing penetration blood-brain barrier (BBB), targeting tumors, enabling release. Additionally, also discuss clinical discoveries, highlighting achievements obstacles process converting these technologies into effective GBM. study offers thorough examination present status prospects

Language: Английский

Citations

0
INFLUENCE OF DRUG DELIVERY SYSTEMS ON THE SAFETY AND EFFECTIVENESS PROFILE OF RIBAVIRIN DOI Open Access
Iosif B. Mikhel,

S. A. TITOVA,

Е. О. Бахрушина

et al.

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 65 - 77

Published: March 7, 2025

Ribavirin is an antiviral drug with a wide spectrum of pharmacological activity. The development delivery systems that increase the safety and effectiveness ribavirin has been subject scientific research for decades. aim this article to examine published information on topic, evaluate it according several criteria, outline primary perspectives within fields pharmacy pharmacology. results evaluation indicate that, despite extensive ongoing discourse surrounding potential modifications international community, majority publications adopt illustrative approach. Many relevant promising applied studies require further development, comprehensive biopharmaceutical indicator testing, rigorous clinical efficacy assessment, thorough patient compliance.

Language: Английский

Citations

0
Development and In Vitro and In Vivo Efficacy Investigation of Multifunctional, Targeted, Theranostic Liposomes for Imaging and Photodynamic Therapy of Glioblastoma DOI
Fidan Gülçin ONARAL, Mine Silindir‐Gunay,

Sıla Ulutürk

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 101, P. 106236 - 106236

Published: Oct. 5, 2024

Language: Английский

Citations

1
Trivalent Disulfide Unit-Masked System Efficiently Delivers Large Oligonucleotide DOI Creative Commons
Lei Wang, Xiao Liu,

Yiliang Wu

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(17), P. 4223 - 4223

Published: Sept. 5, 2024

Oligonucleotide drugs are shining in clinical therapeutics, but efficient and safe delivery systems severely limit their widespread use. A disulfide unit technology platform based on dynamic thiol exchange chemistry at the cell membrane has potential for drug delivery. However, alteration of CSSC dihedral angle induced by different substituents directly affects effectiveness this its stability. Previously, we constructed a trivalent low that can effectively promote cellular uptake small molecules. Here, novel unit-masked oligonucleotide hybrid unit, motivated prodrug design. Cellular imaging results showed such system exhibited superior efficiency than commercial Lipo2000 without cytotoxicity. The reagents significantly reduced (57–74%), which proved to be endocytosis-independent. In addition, vivo distribution experiments mice rapidly distributed liver tissues with duration action more 24 h, representing means silencing genes involved pathogenesis liver-like diseases. conclusion, deliver large drugs.

Language: Английский

Citations

0