Published: Jan. 1, 2024
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 136086 - 136086
Published: Sept. 1, 2024
Language: Английский
Citations
3
Molecular Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 26, 2024
The blood-brain barrier (BBB) is a highly selective network of various cell types that acts as filter between the blood and brain parenchyma. Because this, BBB remains major obstacle for drug delivery to central nervous system (CNS). In recent years, there has been focus on developing modifiable platforms, such monoclonal antibodies (mAbs), nanobodies (Nbs), peptides, nanoparticles, both therapeutic agents carriers targeted treat cancers diseases. Methods bypassing can be invasive or noninvasive. Invasive techniques, transient disruption using low pulse electrical fields intracerebroventricular infusion, lack specificity have numerous safety concerns. this review, we will noninvasive transport mechanisms offer high levels biocompatibility, personalization, are regarded generally safer than their counterparts. Modifiable platforms designed noninvasively traverse through one more following pathways: passive diffusion physio-pathologically disrupted BBB, adsorptive-mediated transcytosis, receptor-mediated shuttle-mediated somatic gene transfer. Through understanding pathways, new applications, including Chimeric Antigen Receptors T-cell (CAR-T) therapy, approaches across emerging.
Language: Английский
Citations
2
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 102, P. 106322 - 106322
Published: Oct. 24, 2024
Language: Английский
Citations
2
Published: Jan. 8, 2024
This study gived an overview on the current treatment of glioblastoma. Glioblastoma, or glioma, is one most common type brain cancer, and have been a concern for human decades due to its threats health. Due prevalence glioma other related tumors, history began far early in 18th century investigation continues until now, studies are aiming target more precise way, including through various treatments. summarizes different strategies both vitro vivo, included old new as well advancements them. Nowadays, there many advances treatment, utilizing development based previous strategies, researches targeting. Glioma involving biomaterial good future prospects still needs attention.
Language: Английский
Citations
1
Biomedical Engineering Advances, Journal Year: 2024, Volume and Issue: 7, P. 100122 - 100122
Published: April 9, 2024
Glioblastoma multiform (GBM), the most occurring brain tumor comprises radiation therapy, chemotherapy, and surgery as its treatment modalities. A significant hurdle is insufficient or impeded transport of drugs to central nervous system (CNS), linked protective influence blood-brain barrier (BBB). Nanotechnology can help deliver therapeutic into (CNS) by crossing BBB. Paclitaxel (PTX) a broad-spectrum anticancer compound that possesses scientifically proven activity. Despite having limited applications due partial solubility toxicity cosolvent preparation, it has shown encouraging outcomes in GBM. In these cases, nanotechnology nanoparticles added certain advantages such increasing drug half-life, lowering toxicity, enhancing permeability retention across BBB targeting. This review article aimed at summarizing current state research works on (NPs) containing PTX Glioblastoma.
Language: Английский
Citations
1
Medicina, Journal Year: 2024, Volume and Issue: 60(11), P. 1888 - 1888
Published: Nov. 18, 2024
Gliomas are the most common primary brain tumors, representing approximately 28% of all central nervous system tumors. These tumors characterized by rapid progression and show a median survival 18 months. The therapeutic options consist surgical resection followed radiotherapy chemotherapy. Despite multidisciplinary approach biomolecular role targeted therapies, progression-free is 6-8 incomplete tumor compliance with treatment due to several factors such as presence blood-brain barrier, numerous pathways involved in transformation, intra-tumoral mutations. Among these, interaction between mutations genes bio-energetic metabolism functional response has become protagonist studies. In this scenario, main played mitochondria, cellular organelles delimited double membrane containing their own DNA (mtDNA), which participates processes regulation metabolism, proliferation, apoptosis also source energy production. Therefore, it understood that mitochondrion, specifically its alteration, leading figure including acquisition mitochondrial cells subsequent identification so-called mitochondria-related (MRGs), both (mutation Complex I) structural (mutations III/IV), have been seen play an important metabolic reprogramming increased resistance apoptosis, tumorigenesis. This demonstrates these alterations could not only intrinsic biology but extrinsic one associated response. We aim summarize dysfunction interactions present gliomas how they might impact prognosis.
Language: Английский
Citations
1
Journal of drug targeting, Journal Year: 2024, Volume and Issue: 32(9), P. 1005 - 1028
Published: June 26, 2024
Glioblastoma, a formidable brain cancer, has remained therapeutic challenge due to its aggressive nature and resistance conventional treatments. Recent data indicate that aptamers, short synthetic DNA or RNA molecules can be used in anti-cancer therapy their better tumour penetration, specific binding affinity, longer retention sites ability cross the blood-brain barrier. With modify these oligonucleotides through selection process, using rational design them, post-SELEX aptamers offer several advantages glioblastoma treatment, including precise targeting of cancer cells while sparing healthy tissue. This review discusses pivotal role diagnosis, emphasising potential enhance treatment efficacy also highlights recent advancements aptamer-based therapies which transform landscape offering renewed hope patients clinicians alike.
Language: Английский
Citations
0
Particle & Particle Systems Characterization, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 10, 2024
Abstract Carbon dots (CDs), which belong to the class of zero‐dimensional carbon‐based nanomaterials, have garnered significant interest owing their wide array applications spanning from electronics industry healthcare sector. This work employs a facile, inexpensive approach synthesize green luminescent carbon (J‐10) potential medicinal plant named Justicia Wynaadensis by one‐step hydrothermal method. A nanocomposite ( JT‐10 ) CDs is prepared adding TiO 2 nanoparticles derived synthesis Lavandula leaves. The J‐10 and are further characterized X‐ray Diffraction spectroscopy (XRD), Transmission Electron Microscopy (TEM), Raman analysis Photoelectron Spectroscopy (XPS), Fourier transform infrared techniques (FTIR), UV–vis spectroscopy, Photoluminescence (PL), Fluorescence or PL lifetime analysis. average size synthesized 1.85 nm exhibits an excitation‐dependent fluorescence nature at 320 nm. calculated be 5.80 2.84 ns respectively. Offering these unique optical properties biocompatibility, synthesised material suitable for investigating binding affinity interaction mechanisms with DNA. use in DNA studies contributes development sustainable efficient nanomaterials biosensors, drug delivery, gene therapy.
Language: Английский
Citations
0
Published: Jan. 1, 2024
Language: Английский
Citations
0