Materials Today Bio, Journal Year: 2024, Volume and Issue: 28, P. 101226 - 101226
Published: Sept. 6, 2024
Language: Английский
TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118214 - 118214
Published: Feb. 1, 2025
Language: Английский
Citations
0
International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 3219 - 3234
Published: March 1, 2025
Osteoarthritis (OA) is characterized by the degeneration of articular cartilage caused several factors which novel most trends include microbiota. Specific microbiota and role in development OA less clear. The presumed to influence occurrence progression mainly via immune modulation. In recent years, bone marrow mesenchymal stem cells (MSCs) have shown great potential for treatment OA, however, therapeutic efficiency has been seriously affected harsh microenvironment joint cavity. At present, many strategies used enhance function MSCs, among them, engineering are a promising method. Therefore, this review focuses on latest research how affects cell repair, use engineered MSCs OA. addition, can exosomes as strategy treating Our provides comprehensive perspective therapy
Language: Английский
Citations
0
ACS Materials Letters, Journal Year: 2025, Volume and Issue: unknown, P. 1462 - 1487
Published: March 20, 2025
Language: Английский
Citations
0
Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101697 - 101697
Published: March 1, 2025
Language: Английский
Citations
0
Polymers, Journal Year: 2025, Volume and Issue: 17(7), P. 915 - 915
Published: March 28, 2025
The use of miRNA in therapeutics has, since its discovery 1993, attracted tremendous attention, and research this area has progressed rapidly. Since the advent RNA interference (RNAi), much about nucleic acid siRNA been elucidated. At same time, no miRNA-based drugs have passed phase II clinical trials. A significant obstacle to drug development is ease degradation relatively short half-life vivo miRNA. Hydrogels are networks cross-linked polymer chains with ability 'swell'. They shown remarkable capabilities that improve properties other researched carriers. In combination modification strategies inorganic carriers, hydrogel systems show promise for sustained delivery novel drugs. Although reported recently, focus predominantly on their wound-healing properties, a dearth information carrier abilities. This paper focuses more latest advancements developing hydrogels as system, emphasizing review will cover methods fabrication, efforts release, biomedical applications, future prospects.
Language: Английский
Citations
0
Tissue Engineering and Regenerative Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 15, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Abstract Pelvic organ prolapse (POP) is a common and distressing condition affecting women, particularly those with history of vaginal delivery. The impact extracellular vesicles derived from adipose‐derived mesenchymal stem cells (ADSC‐EVs) on pelvic floor tissue injury remains unclear. Due to their short half‐life rapid clearance in vivo, ADSC‐EVs lose efficacy quickly. To address this, an injectable tetra‐PEG hydrogel encapsulate (PEG@EVs) developed. formed by tetra‐PEG‐NH 2 tetra‐PEG‐NHS through ammonolysis reaction, leading the formation amide bonds within seconds. Vaginal wall POP patients shows disruption matrix, lipid peroxidation, inflammation. In vitro, significantly reduce H₂O₂‐induced oxidative stress, oxidation, apoptosis, while enhancing expression Nrf2 its downstream targets—CAT, NQO1, HO‐1, SOD2. also upregulate GPX4 SLC7A11, reducing mitochondrial damage mitigating ferroptosis. inhibitor ML385 reverses these protective effects. rat model childbirth injury, PEG@EVs treatment promotes nuclear translocation, induces M1‐to‐M2 macrophage conversion, reduces inflammation, stimulates collagen deposition, thereby accelerating repair. findings this study may serve as foundation for early targeted intervention POP, representing promising therapeutic approach.
Language: Английский
Citations
0
Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Abstract Arthritis is a degenerative disease characterized by chronic cartilage degeneration. It affects hundreds of millions people worldwide and often has serious consequences such as joint pain swelling, limited mobility, deformity. However, conventional treatments still struggle to achieve satisfactory results. Finding more effective for arthritis remains an important clinical challenge. As hydrogels have unique 3D spatial mesh structure, significant material interaction ability, adjustable mechanical properties, good biodegradability, they can provide suitable cellular or tissue microenvironment, their potential in scaffolding effect, lubrication, anti‐inflammatory drug delivery expected be potent therapeutic approach the treatment osteoarthritis. In this review, three aspects hydrogel products osteoarthritis are comprehensively summarized discussed, namely, selection gel design, exploration cross‐linking mechanisms, mechanisms therapy osteoarthritis, focus on advantages limitations applications, which point out direction development strategy innovative field, applied research, transformation.
Language: Английский
Citations
0
Cells, Journal Year: 2025, Volume and Issue: 14(9), P. 669 - 669
Published: May 2, 2025
Osteoarthritis (OA) is a degenerative joint disease that significantly impacts quality of life and poses growing economic burden. Adipose tissue-derived therapies, including both cell-based cell-free products, have shown promising potential in promoting cartilage repair, modulating inflammation, improving function. Recent studies clinical trials demonstrated their regenerative effects, highlighting feasibility as novel treatment approach for OA. This review summarises the therapeutic mechanisms latest advancements adipose providing insights into applications future prospects.
Language: Английский
Citations
0
Macromol—A Journal of Macromolecular Research, Journal Year: 2024, Volume and Issue: 4(2), P. 165 - 189
Published: April 1, 2024
MiRNA-based therapies represent an innovative and promising strategy applicable to various medical fields, such as tissue regeneration the treatment of numerous diseases, including cancer, cardiovascular problems, viral infections. MiRNAs, a group small non-coding RNAs, play critical role in regulating gene expression at post-transcriptional level modulate several signaling pathways that maintain cellular homeostasis. The clinical trials discussed review herald new therapeutic era for miRNAs, particularly engineering, using synthetic exogenous mimic miRNAs antisense (anti-miRNAs) restore health. This provides overview miRNAs’ biogenesis, mechanism action, regulation, potential applications, followed by examination challenges associated with transport delivery miRNAs. possibility non-viral vectors protect against degradation ensure effective miRNA is highlighted, focusing on advantages emerging use 3D biomaterial scaffolds anti-miRNAs facilitate repair regeneration. Finally, assesses current landscape miRNA-activated scaffold preclinical studies bone, cartilage, skin tissues, emphasizing their emergence frontier personalized medicine.
Language: Английский
Citations
3