miRNAs and their multifaceted role in cutaneous wound healing

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 4, 2025

Language: Английский

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Current advances in the development of microRNA-integrated tissue engineering strategies: a cornerstone of regenerative medicine

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 16, 2024

Regenerative medicine is an innovative scientific field focused on repairing, replacing, or regenerating damaged tissues and organs to restore their normal functions. A central aspect of this research arena relies the use tissue-engineered scaffolds, which serve as structural supports that mimic extracellular matrix, providing environment orchestrates cell growth tissue formation. Remarkably, therapeutic efficacy these scaffolds can be improved by harnessing properties other molecules compounds have crucial roles in healing regeneration pathways, such phytochemicals, enzymes, transcription factors, non-coding RNAs (ncRNAs). In particular, microRNAs (miRNAs) are a class tiny (20–24 nt), highly conserved ncRNAs play critical role regulation gene expression at post-transcriptional level. Accordingly, miRNAs involved myriad biological processes, including differentiation, proliferation, apoptosis, well regeneration, angiogenesis, osteogenesis. On basis, over past years, number studies demonstrated integrated into create advanced platforms precisely modulate cellular behavior offer controlled targeted release optimize repair regeneration. Therefore, current review, we discuss most recent advances development miRNA-loaded provide overview future outlooks should aborded area study order lay groundwork for clinical translation engineering approaches.

Language: Английский

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MicroRNA Nobel Prize: Timely Recognition and High Anticipation of Future Products—A Prospective Analysis

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 12883 - 12883

Published: Nov. 29, 2024

MicroRNAs (miRNAs) maintain cellular homeostasis by blocking mRNAs binding with them to fine-tune the expression of genes across numerous biological pathways. The 2024 Nobel Prize in Medicine and Physiology for discovering miRNAs was long overdue. We anticipate a deluge research work involving repeat history prizes awarded on other RNAs. Although miRNA therapies are included several complex diseases, realization that regulate their roles addressing hundreds diseases expected; but advancement drug discovery tools, we even faster entry new drugs. To promote this, provide details current science, logic, intellectual property, formulations, regulatory process anticipation many more researchers will introduce novel based discussion advice provided this paper.

Language: Английский

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