Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
29, P. 101253 - 101253
Published: Sept. 25, 2024
Interior
bone-tissue
regeneration
and
rapid
tumor
recurrence
post-resection
are
critical
challenges
in
osteosarcoma
other
bone
cancers.
Conventional
tissue
engineering
scaffolds
lack
inhibitory
effects
on
recurrence.
Herein,
multifunctional
(named
DOX/PDA@CDHA)
were
designed
through
the
spontaneous
polymerization
of
Dopamine
(PDA)
surface
Calcium
Deficient
Hydroxyapatite
(CDHA)
scaffolds,
followed
by
situ
loading
chemotherapeutic
drug
Doxorubicin
(DOX).
The
PDA
coating
endowed
with
significant
photothermal
properties,
while
gradual
release
DOX
provided
an
effective
effect.
on-demand
at
sites,
triggered
dual
stimulation
(near-infrared
(NIR)
light
acidic
pH
typical
microenvironments),
specifically
targets
cancer
cells,
thereby
mitigating
systemic
side
effects.
These
unique
characteristics
facilitated
eradication
both
vitro
vivo.
Moreover,
scaffold's
composition,
which
mimics
mineral
phase
natural
is
enhanced
PDA's
biocompatibility,
promotes
osteogenic
angiogenic
processes.
This
facilitates
not
only
but
also
healthy
tissue.
Collectively,
this
study
presents
a
potent
candidate
for
defects
induced
osteosarcoma.
Materials & Design,
Journal Year:
2024,
Volume and Issue:
244, P. 113145 - 113145
Published: July 8, 2024
The
repair
of
secondary
critical
bone
defects
is
an
international
medical
challenge.
Bone
tissue
engineering
provides
methods
and
technology
for
repair.
regeneration
mechanism
serves
as
inspiration
the
material
structural
design
scaffolds.
In
terms
materials,
this
review
draws
from
biological
characteristics
host
cells
in
osteogenic
microenvironment
(including
osteoblast
lineage,
vascular
cell
inflammatory
cells,
etc.),
reviewing
regulatory
mechanisms
self-healing
proposing
autonomous
living
materials
scaffolds
which
prepared
by
in-situ
manufacturing.
Autonomous
regulate
migration,
proliferation
differentiation
real
time
releasing
steadily
long-term.
Regarding
structure,
we
functional
role
natural
structures
homeostasis,
providing
insights
into
bone-inspired
Due
to
conflict
between
mechanical
properties
ability,
proposes
assembled
They
can
prolong
half-life
provide
support
attachment
points
new
growth,
autonomously
microenvironment.
have
potential
advance
research
progress
field
pave
way
novel
clinical
treatments.
Journal of Materials Science Materials in Medicine,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: March 15, 2025
Local
therapy
involving
injectable
hydrogel
systems
loaded
with
doxorubicin
(DOX)
has
garnered
significant
attention
in
the
realm
of
osteosarcoma
(OS)
research.
Nevertheless,
it
been
noted
that
local
delivery
high-dose
DOX
exerts
a
pronounced
inhibitory
impact
on
osteogenesis,
which
is
detrimental
to
restoration
functional
capabilities
after
OS
treatment.
To
address
this
challenge,
we
have
designed
self-assembled
system
integrates
photodynamic
and
chemodynamic
therapy,
aiming
enhance
efficacy
while
mitigating
adverse
effects
osteogenic
differentiation.
In
study,
an
sodium
alginate
(SA)
was
fabricated
by
encapsulating
titanium
carbide
powder
(Ti3C2Tx)
osteoprotegerin
Icariin
(ICA)
along
DOX.
This
demonstrated
remarkable
drug-loading
capacity
sustained
drug
release.
Furthermore,
under
near-infrared
(NIR)
irradiation,
displayed
outstanding
photothermal
effects,
which,
conjunction
chemotherapy
phototherapy,
effectively
eradicated
UMR-106
tumor
cells
vitro.
The
incorporation
ICA
not
only
enhanced
anti-tumor
effect
but
also
alleviated
differentiation
inhibition
bone
marrow
mesenchymal
stem
(BMSCs).
vivo,
findings
further
confirmed
ITD/SA
hydrogels
can
synergistically
heighten
anti-osteosarcoma
effectiveness
toxicity.
Given
these
benefits,
holds
extensive
application
prospects
OS.
ACS Nano,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 8, 2025
Bone
tumors
with
high
mortality
and
disability
have
become
a
major
clinical
challenge.
Herewith,
it
is
necessary
to
design
materials
for
bone
tumor
therapy
repair.
In
this
work,
Fe-doped
polypyrrole
(Fe-Ppy)
CaO2
are
constructed
on
sulfonated
polyetheretherketone
(SP)
form
multistage-responsive
coating.
The
coating
achieves
long-lasting
antitumor
through
chemodynamic
(CDT),
photothermal
(PTT),
combined
immunotherapy.
Fe-Ppy
acts
as
an
electron
pump
replenish
Fe2+
oxidizing
-NH-
-N+-,
which
lasts
the
Fenton
reaction
persistently
produces
reactive
oxygen
species
(ROS)
in
microenvironment
(TME).
selectively
provides
exogenous
H2O2
response
TME
boost
cycle.
Stronger
near-infrared
light
absorption
due
Fe
doping
more
photon
traps
caused
by
porous
structure-induced
scattering
refraction
diminishment
improve
conversion
of
modified
SP.
Furthermore,
ROS
effective
enhance
M1
activation
secrete
TNF-α
IFN
kill
cells.
After
therapy,
Fe-Ppy@CaO2-modified
SP
could
adaptively
switch
macrophage
M2
promote
osteogenesis
abolishment
NIR
stimulation.
summary,
ROS,
enhanced
conversion,
immunomodulation
potential
candidate
tissue
Materials Research,
Journal Year:
2025,
Volume and Issue:
28
Published: Jan. 1, 2025
This
study
developed
a
bone
cement
based
on
hydroxyapatite
(HAp)
and
magnetically
activated
with
cobalt
ferrite
(CoFe2O4)
magnetite
(Fe3O4)
nanoparticles
for
potential
use
in
orthopedic
surgeries
like
vertebroplasty.
Magnetic
(MNPs@SiO2)
were
mixed
HAp
varying
ratios
(30:70,
50:50,
70:30)
incorporated
into
hydrogel
matrix
of
carboxymethylcellulose,
glycerin,
distilled
water,
forming
fluid-viscous
magnetic
cements.
These
analyzed
through
XRD,
SEM,
swelling
degree,
pH,
setting
time,
mechanical
strength,
properties,
cell
viability.
XRD
confirmed
the
crystalline
phases
each
component,
while
SEM
revealed
hybrid
morphologies
micropores.
Cements
higher
content
exhibited
greater
simulated
body
fluid
(SBF)
faster
reaction
kinetics,
values
between
58%
91%.
After
7
days
SBF,
pH
stabilized
7.0
7.3,
ensuring
biocompatibility.
Setting
times
ranged
from
12
to
25
minutes,
making
them
suitable
clinical
use.
Compressive
strengths
28.91
MPa
30.06
achieved
after
14
days,
indicating
structural
stability.
Ferrimagnetic
behavior
was
observed,
magnetizations
reaching
27.30
emu/g
31.08
ferrite.
All
formulations
non-cytotoxic
behavior,
confirming
their
safety
biomedical
applications.
Small,
Journal Year:
2024,
Volume and Issue:
21(5)
Published: Dec. 29, 2024
Abstract
Post‐surgical
recurrence
and
extensive
bone
defects
pose
significant
challenges
during
osteosarcoma
treatment.
These
issues
can
be
addressed
using
a
novel
strategy
that
promotes
repair
after
removing
residual
tumors.
Therefore,
3D‐printed
porous
polylactic
acid
(PLA)
scaffold
(PH‐GBS@CCP)
filled
with
hydrogel
surface‐modified
nano‐hydroxyapatite
(nHA)
is
designed.
The
hydrogel,
composed
of
gelatin
modified
methacrylic
anhydride
(GelMA),
sodium
alginate
(SA),
borax,
contains
Cu–Cys–PEG
nanoparticles
(CCP)
cRGD
fk
‐PEG
2K
‐DSPE.
It
injected
into
the
PLA
crosslinked
under
UV.
This
acts
as
buffer
medium
between
bone,
reducing
cell
abrasion,
carrier
for
responsive
release
tumor‐targeting
CCP.
provides
support
microenvironment
required
repair.
In
early
treatment,
acidic
tumor
disintegration
CCP
release,
depleting
glutathione
converting
Cu
2+
to
+
Fenton‐like
reaction.
generates
reactive
oxygen
species,
strengthening
proptosis
effect,
killing
tumor.
later
elimination,
normalized
pH
slow
along
nHA,
promote
osteogenic
differentiation,
providing
sustained
effect.
Overall,
multifunctional
composite
achieved
sequential
management
post‐surgical
through
tumor‐killing
effects.
