Investigation of PLA/ZnO Nanofibers for Piezoelectric and Nerve Regeneration Applications

Sensors and Actuators A Physical, Journal Year: 2025, Volume and Issue: unknown, P. 116340 - 116340

Published: Feb. 1, 2025

Language: Английский

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Structure-function-guided valorization of wheat straw cellulose toward multifunctional nanocellulose film

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160712 - 160712

Published: Feb. 1, 2025

Language: Английский

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On the Structural and Biological Effects of Hydroxyapatite and Gold Nano-Scale Particles in Poly(Vinylidene Fluoride) Smart Scaffolds for Bone and Neural Tissue Engineering

Molecules, Journal Year: 2025, Volume and Issue: 30(5), P. 1041 - 1041

Published: Feb. 25, 2025

Piezoelectric materials, due to their ability generate an electric charge in response mechanical deformation, are becoming increasingly attractive the engineering of bone and neural tissues. This manuscript reports effects addition nanohydroxyapatite (nHA), introduction gold nanoparticles (AuNPs) via sonochemical coating, collector rotation speed on formation electroactive phases biological properties electrospun nanofiber scaffolds consisting poly(vinylidene fluoride) (PVDF). FTIR, WAXS, DSC, SEM results indicate that nHA increases content fiber alignment. The rotational not only alignment but also PVDF PVDF/nHA fibers. Increased orientation each additives resulted increased SFE water uptake. In vitro tests conducted MG-63 hiPSC-NSC cells showed adhesion cell proliferation. PVDF-based composites with AuNPs promising candidates for development advanced tissue applications, combining electrical functionality activity support regeneration.

Language: Английский

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Visible Periodic Piezoelectric Domains in Silk Fibroin for Neurite‐Orientated Extension

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: March 23, 2025

Abstract The development of visible periodic piezoelectric domains is highly attractive but challenging to overcome the homogeneous distribution and lack visualization electric field on traditional piezopolymers. This work reports an in situ synthesis create customized silver patterns with micron‐level distinguishability. method serves form endows silk fibroin (SF) generator maximum root mean square current, energy density, voltage 5.1 mA, 6.7 W m −2 529.5 mV, respectively, under ultrasound intensity 1.0 cm . oriented periodically distributed into SF film ultrasound‐driven assistance remarkably regulates neurite directional growth, length, gene expression. Additionally, these enable direct timely observation field's effect neurites by biological microscopy. approach paves way for great potential tailored stimulation cell biology medical engineering.

Language: Английский

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Biomimetic Piezoelectric Periosteum‐Bone Integrated Implant Promotes Bone Defect Repair by Remodeling Osteogenic Microenvironment

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Abstract Bone defects caused by trauma, infection, or tumors pose significant clinical challenges, particularly in large with poor healing outcomes. Traditional repair methods often fail to address the complex regenerative microenvironment. This study introduces a novel biomimetic piezoelectric periosteum‐bone bilayer implant designed remodel osteogenic microenvironment and enhance bone defect repair. The comprises an upper electrospun polyvinylidene fluoride‐curcumin‐loaded magnesium metal–organic framework (PVDF‐MOF/Cur, PMC) periosteum scaffold lower hydroxyapatite@gelatin methacrylate (HA@GelMA) (PMC+HA@GelMA, PMCG). In whole PMCG implant, PMC improves properties of PVDF enables sustained drug release via Mg‐MOF loaded Cur. Meanwhile, HA@GelMA facilitates marrow mesenchymal stem cells differentiation regeneration. Additionally, further accelerates promoting neuronal differentiation, as well enhancing angiogenesis regulating macrophage polarization. Transcriptome sequencing reveals that activates key signaling pathways associated angiogenesis, neurogenesis, inflammation regulation, osteogenesis, including HIF‐1α, PI3K‐Akt, JAK‐STAT, TGF‐β pathways. Thus, this work highlights multifunctional capabilities remodify accelerate repair, which offers promising platform for advancing tissue

Language: Английский

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Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?

Frontiers in Bioengineering and Biotechnology, Journal Year: 2024, Volume and Issue: 12

Published: May 9, 2024

Intervertebral disc degeneration (IDD) due to multiple causes is one of the major low back pain (LBP). A variety traditional treatments and biologic therapies are currently used delay or even reverse IDD; however, these still have some limitations. Finding safer more effective urgent for LBP patients. With increasing reports it has been found that intervertebral (IVD) can convert pressure loads from spine into electrical stimulation in a ways, this great importance modulating cell behavior, immune microenvironment promoting tissue repair. However, when occurs, normal structures within IVD destroyed. This eventually leads weakening loss self-powered. Currently various piezoelectric materials with unique crystal mimic effect tissues. Based on this, tissue-engineered scaffolds prepared using widely regenerative repair types tissues, there no their use treatment IDD. For reason, we propose utilize biomaterials excellent biocompatibility self-powered properties be implanted degenerated help restore type number, extracellular matrix, modulate responses. It provides feasible novel therapeutic approach clinical

Language: Английский

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Biomimetic electrospun PVDF/self-assembling peptide piezoelectric scaffolds for neural stem cell transplantation in neural tissue engineering

RSC Advances, Journal Year: 2024, Volume and Issue: 14(30), P. 21277 - 21291

Published: Jan. 1, 2024

Piezoelectric materials can provide

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From innovation to clinic: emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101415 - 101415

Published: Dec. 19, 2024

Language: Английский

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Therapeutic Advances in Peripheral Nerve Injuries: Nerve-Guided Conduit and Beyond

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Peripheral nerve injury (PNI), a challenging neurosurgery issue, often leads to partial or complete loss of neuronal functions and even neuropathic pain. Thus far, the gold standard for treating peripheral deficit remains autografts. While numerous reviews have explored PNI regeneration, this work distinctively synthesizes recent advancements in tissue engineering-particularly four-dimensional (4D) bioprinting exosome therapies-with an emphasis on their clinical translation. By consolidating findings spanning molecular mechanisms therapeutic applications, review proposes actionable framework advancing experimental strategies toward clinically viable solutions. Our critically evaluates emerging innovations such as dynamically adaptive 4D-printed conduits exosome-based therapies, underscoring potential match conventional autografts achieving functional restoration. Impact Statement Although several previous been made describing with great detail degenerative regenerative nervous systems, well existing exploratory treatment strategies, we focus more latest each those topics.

Language: Английский

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Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

The Canadian Journal of Chemical Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 18, 2024

Abstract Nerve guidance conduits (NGCs) have been shown to be effective in promoting nerve regeneration a variety of clinical applications, including defects resulting from trauma or surgery. By providing conducive environment for growth, NGCs can help restore function nerve‐damaged patients. Challenges include limited repair length, difficulty replicating natural nerve, and rapid substance degradation affecting neurotrophic factor delivery. Considering these issues with mass transfer fluid structure interaction (FSI) emphasizes the need enhancing efficiency. To facilitate growth deliver appropriate amount factors, designed specific topological, mechanical, biological properties. Additionally, considerations must given functional FSI design. An intelligent NGC design is proposed as an evaluation‐optimization AI‐based method. It found that parameters significantly impact physical properties being optimized, hydraulic pressure, porosity, diffusivity, water absorption, maximum stress. The mathematical surrogate model obtained data‐based modelling used artificial intelligence (AI) optimization algorithms, differential evolution (DE), non‐dominated sorting genetic algorithm II (NSGA‐II). revealed both DE NSGA algorithms generate nearly identical solutions, ensuring robustness ML optimization. Our results show thickness 750 μm more than 170% augmentation porosity. Moreover, at constant ovality, increasing channel 39.2% accurate forecasting characteristics on regarding factors enables hopeful outlook future treatment injuries advanced tissue engineering.

Language: Английский

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