Multifaceted Hydrogel Scaffolds: Bridging the Gap between Biomedical Needs and Environmental Sustainability

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 2, 2024

Abstract Hydrogels are dynamically evolving 3D networks composed of hydrophilic polymer scaffolds with significant applications in the healthcare and environmental sectors. Notably, protein‐based hydrogels mimic extracellular matrix, promoting cell adhesion. Further enhancing proliferation within these matrix‐metalloproteinase‐triggered amino acid motifs. Integration cell‐friendly modules like peptides proteins expands hydrogel functionality. These exceptional properties position for diverse applications, including biomedicine, biosensors, remediation, food industry. Despite progress, there is ongoing research to optimize biomedical further. Engineering novel favorable characteristics crucial regulating tissue architecture facilitating ecological remediation. This review explores synthesis, physicochemical properties, biological implications various types their extensive biomedicine It elaborates on potential bridging gap between advancements sector solutions issues.

Language: Английский

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Chiral Engineered Biomaterials: New Frontiers in Cellular Fate Regulation for Regenerative Medicine

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Abstract Chirality, the property of objects that are nonsuperimposable on their mirror images, plays a crucial role in biological processes and cellular behaviors. Chiral engineered biomaterials have emerged as promising approach to regulating fate regenerative medicine. However, few reviews provide comprehensive examination recent advancements chiral applications regulation. Herein, various fabrication techniques available for biomaterials, including use molecules, surface patterning, self‐assembly discussed. The mechanisms through which influence responses, such modulation adhesion receptors, intracellular signaling, gene expression, explored. Notably, demonstrated ability guide stem cell differentiation augment tissue‐specific functions. potential musculoskeletal disorders, neurodegenerative diseases, cardiovascular wound healing highlighted. Challenges future perspectives, standardization methods translation clinical settings, addressed. In conclusion, offer exciting prospects precisely controlling fate, advancing medicine, enabling personalized therapeutic strategies.

Language: Английский

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ADM-Loaded GelMA hydrogel promotes endogenous dental pulp regeneration: an in vitro and in vivo study

Journal of Endodontics, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 1, 2024

To prepare a gelatin methacryloyl (GelMA) hydrogel scaffold embedded with adrenomedullin (ADM) and investigate its impact underlying mechanisms in endogenous pulp regeneration. ADM was evenly distributed within the GelMA through simple conventional physical mixing technique. The underwent characterization via scanning electron microscopy, alongside assessments of swelling, degradation, release properties. Biocompatibility evaluated using cytoskeletal live-dead staining techniques. hydrogel's influence on dental stem cells' proliferation, migration, differentiation assessed CCK-8 assays, Transwell alizarin red alkaline phosphatase staining. Transcriptomics provided insights into potential mechanisms. angiogenic effects umbilical vein endothelial cells were examined scratch tube formation assays. In vivo, composite regenerative capacity tested rat model Statistical analysis involved Student's t-test one-way variance, significance set at P < .05. ADM-loaded (GelMA@ADM) displayed porous architecture under microscopy conducive to cell adhesion demonstrated excellent biocompatibility. vitro experiments showed that GelMA@ADM significantly boosted differentiation, enhanced activity after one week treatment. Corresponding vivo revealed facilitated new vascularized tissue 2 weeks effectively promotes proliferation augments vascularization by cells, fosters creation tissue. These findings underscore for

Language: Английский

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Improved Catalytic Performance of Lipase Within Hydrogel Microspheres Incorporating L/D‐Co₃O₄ Nanoparticles

Small Methods, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Lipases have drawn significant attention due to their crucial roles across various industries, including oil processing, food, medicine, and daily chemicals. Nevertheless, catalytic efficiency is susceptible fluctuations in external environmental conditions, which remains a major barrier broader application. In this research, chiral hydrogel microspheres (HMSs) are developed by incorporating L/D-Co

Language: Английский

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