Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing DOI Open Access

Wang Zhang,

Shuyi Qian, Jia Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9948 - 9948

Published: Sept. 15, 2024

Severe burns are one of the most devastating injuries, in which sustained inflammation and ischemia often delay healing process. Pro-angiogenic growth factors such as vascular endothelial factor (VEGF) have been widely studied for promoting wound healing. However, short half-life instability VEGF limit its clinical applications. In this study, we develop a photo-crosslinked hydrogel dressing from methacrylate hyaluronic acid (MeHA) bonded with pro-angiogenic prominin-1-binding peptide (PR1P). The materials were extruded bed situ formed via exposure to short-time ultraviolet radiation. study shows that PR1P-bonded significantly improves recruitment, tubular formation, cell migration vitro. Swelling, Scanning Electron Microscope, mechanical tests indicate does not affect overall physical properties hydrogels. For vivo studies, enhances neovascularization accelerates closure both deep second-degree burn full-thickness excisional models. Western blot assay benefits can be related activation VEGF–Akt signaling pathway. These results suggest efficiently promotes recruitment angiogenesis skin regeneration, indicating potential applications

Language: Английский

In situ UNIversal Orthogonal Network (UNION) bioink deposition for direct delivery of corneal stromal stem cells to corneal wounds DOI
Lucia G. Brunel, Betty Cai, Sarah M. Hull

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 414 - 430

Published: Feb. 24, 2025

Language: Английский

Citations

1
Localised Therapies Using 3D‐Printed Collagen‐Based Micro‐Implant for Ocular Indications DOI Creative Commons

Hamid Heidari Kashkooli,

Arian Farokh, Sajad Mohammadi

et al.

Macromolecular Materials and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Abstract Current limitations in treating retinal diseases like age‐related macular degeneration (AMD) and diabetic retinopathy (DR) are due to the short ocular residence time of biologics difficulty precise drug delivery. In turn, frequent injections required, hindering patient compliance, increasing healthcare costs. This study explores development a collagen‐based implant using 3D bioprinting platform address these challenges. The offers dual functionalities: i) sustained localized delivery situ polymerization collagen (IPC) act as reservoirs for prolonged release target tissue ii) scaffold stability through incorporation methacrylated hyaluronic acid (HAMA) enhance mechanical properties IPC implant, making it suitable printing targeted systems. data demonstrates that IPC‐HAMA implants exhibit slow over 80 days. Additionally, enables targeting volumetric control within simulated vitreous humor, overcoming challenges associated with traditional injection methods. innovative approach has potential revolutionize therapy diseases.

Language: Английский

Citations

0
蛋白质水凝胶三维微纳结构的飞秒激光增材-去除双模态加工 DOI

刘赟 Liu Yun,

黄瀚轩 Huang Hanxuan,

肖子峰 Xiao Zifeng

et al.

Chinese Journal of Lasers, Journal Year: 2025, Volume and Issue: 52(8), P. 0802408 - 0802408

Published: Jan. 1, 2025

Citations

0
Preparation and evaluation of p(2-hydroxyethyl methacrylate-co-Acrylamide)/ gelatin/ ammonium polyhedral oligomeric silsesquioxane composite as a candidate for full-thickness wound dressing DOI
Sana Sadraei-Majd, Mohammad Taghi Khorasani, Majid Karimi

et al.

European Polymer Journal, Journal Year: 2025, Volume and Issue: unknown, P. 113954 - 113954

Published: April 1, 2025

Language: Английский

Citations

0
State-of-the-art in natural hydrogel-based wound dressings: Design, functionalization, and fabrication approaches DOI Creative Commons
Hossein Baniasadi

Advances in Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 342, P. 103527 - 103527

Published: April 25, 2025

Language: Английский

Citations

0
Sequential delivery of IL-10 and icariin using nanoparticle/hydrogel hybrid system for prompting bone defect repair DOI Creative Commons
Xiaojun Li, Zhongti Sun,

Xiushuai Shang

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101374 - 101374

Published: Dec. 1, 2024

The treatment of large bone defects remains challenging due to the lack spatiotemporal management immune microenvironment, inflammation response and remodeling. To address these issues, we designed developed a nanoparticle/hydrogel hybrid system that can achieve combined sequential delivery an anti-inflammatory factor (IL-10) osteogenic drug (icariin, ICA). A photopolymerizable composite hydrogel was prepared by combining gelatin methacryloyl (GelMA) heparin-based acrylated hyaluronic acid (HA) hydrogels containing IL-10, poly(dl-lactide-co-glycolide) (PLGA)-HA nanoparticles loaded with ICA were incorporated into hydrogels. demonstrates array features including mechanical strength, injectability photo-crosslinking. rapid release IL-10 from effectively exerts immunomodulatory activity, whereas long-term sustained icariin PLGA-HA significantly triggers differentiation marrow-derived mesenchymal stem cells (BMSCs). Notably, exhibit synergistic effect for remodeling in critical cranial defect rat model. Our findings indicate importance microenvironment high-quality skull remodeling, thus dual-factor releasing could be promising candidate repairing defects.

Language: Английский

Citations

3
Biofabrication: Bioprinting Process, Printing Materials, and the Frontier Applications in Biomedicine DOI Creative Commons

Yuxiang Qin,

Linlin Fan,

Lei Zhan

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown, P. 200175 - 200175

Published: Oct. 1, 2024

Language: Английский

Citations

2
Photo-Crosslinked Pro-Angiogenic Hydrogel Dressing for Wound Healing DOI Open Access

Wang Zhang,

Shuyi Qian, Jia Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 9948 - 9948

Published: Sept. 15, 2024

Severe burns are one of the most devastating injuries, in which sustained inflammation and ischemia often delay healing process. Pro-angiogenic growth factors such as vascular endothelial factor (VEGF) have been widely studied for promoting wound healing. However, short half-life instability VEGF limit its clinical applications. In this study, we develop a photo-crosslinked hydrogel dressing from methacrylate hyaluronic acid (MeHA) bonded with pro-angiogenic prominin-1-binding peptide (PR1P). The materials were extruded bed situ formed via exposure to short-time ultraviolet radiation. study shows that PR1P-bonded significantly improves recruitment, tubular formation, cell migration vitro. Swelling, Scanning Electron Microscope, mechanical tests indicate does not affect overall physical properties hydrogels. For vivo studies, enhances neovascularization accelerates closure both deep second-degree burn full-thickness excisional models. Western blot assay benefits can be related activation VEGF–Akt signaling pathway. These results suggest efficiently promotes recruitment angiogenesis skin regeneration, indicating potential applications

Language: Английский

Citations

1