Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1845 - 1845
Published: Nov. 18, 2024
Over the past two decades, research on innovative micro- and nano-biomaterials has seen a significant surge in bioengineering, biomedicine, regenerative medicine fields [...].
Language: Английский
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 282, P. 137092 - 137092
Published: Nov. 1, 2024
Language: Английский
Citations
4
Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 13
Published: April 23, 2025
Spinal cord injury (SCI) is a severe condition that frequently leads to permanent disabilities and neurological dysfunction. Its progression driven by multifaceted pathophysiology, encompassing direct trauma, secondary cascades, intricate cellular molecular responses. While current therapies focus on alleviating symptoms restoring functionality, achieving effective neural regeneration in the spinal continues be significant challenge. Hydrogels, recognized for their exceptional biocompatibility, conductivity, injectability, have shown great potential as advanced scaffolds support neuronal axonal regeneration. Recently, these materials attracted interest field of SCI rehabilitation research. This review concludes recent progress hydrogel-based strategies rehabilitation, emphasizing distinct properties, underlying mechanisms, integration with bioactive molecules, stem cells, complementary biomaterials. Hydrogels foster providing tailored microenvironment, while features such self-repair, electrical controlled drug release significantly enhance therapeutic experimental models. explores hydrogel technologies applications, underscoring address challenges treatment paving way future clinical implementation.
Language: Английский
Citations
0
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The ability to move cells in space without impairing their behavior is a critical goal the development of functional biomaterials and devices, with applications ranging from regenerative medicine biosensing. In this study, we describe novel approach for simultaneously displacing multiple using magnetized diatom shells. Highly porous biosilica shells diatoms are functionalized through multi-step decoration process involving ferromagnetic nanoparticles. Neuronal then allowed adhere an appropriate duration before being moved magnetically external magnet. We demonstrate safe transfer neuron cell-loaded by pipetting, as well controlled movement twirling or along simple fluidic channel. This proof-of-concept introduces promising strategy safely efficiently relocating simultaneously, paving way innovative tissue engineering, biosensing, beyond.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: May 5, 2025
Osteoporotic tendon-to-bone healing remains a major challenge, as cellular senescence disrupts tissue regeneration and impairs repair outcomes. Although the role of in rotator cuff is increasingly recognized, current strategies often overlook complex pathological context, particularly dual impacts on both bone marrow-derived mesenchymal stem cells (BMSCs) tendon-derived (TDSCs). This gap hampers effective integration, especially under osteoporotic conditions. Herein, composite hydrogel system, quercetin-loaded aligned ultralong hydroxyapatite nanowire/gelatin-hyaluronic acid (Que-AHNW/GH), has been developed to address these challenges. By integrating senolytic quercetin biological cue with highly (HAP) nanowires topographical cue, system remodels senescent microenvironment, alleviating BMSCs TDSCs promoting osteogenesis tenogenesis. Que-AHNW/GH suppresses PI3K/AKT pathway, enhances autophagy, reduces cell types. In vivo, improves tunnel regeneration, tendon repair, integration rats injury. biomechanical strength gait performance demonstrates excellent biosafety. These findings highlight promising potential multifunctional biomaterial for effectively senescence-related healing, offering solution treating injuries.
Language: Английский
Citations
0
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 334 - 345
Published: Sept. 16, 2024
Language: Английский
Citations
1
Gels, Journal Year: 2024, Volume and Issue: 10(12), P. 814 - 814
Published: Dec. 11, 2024
Many tissues exhibit structural anisotropy, which imparts orientation-specific properties and functions. However, recapitulating the cellular patterns found in anisotropic presents a remarkable challenge, particularly when using soft wet hydrogels. Herein, we develop self-assembled magnetic Fe3O4 micropatterns on polyethylene glycol hydrogels utilizing dipole–dipole interactions. Under influence of static field, nanoparticles align into highly ordered structures with height 400–600 nm width 8–10 μm. Furthermore, our layer-by-layer assembly technique enables creation oriented varying densities heights, can be further manipulated to form three-dimensional by adjusting angle field. These applied various substrates, including treated glass slides, standard silicon wafers, polydimethylsiloxane. The patterned scaffolds, modified gold coating, effectively enhance adhesion, orientation, osteogenic differentiation bone marrow-derived stem cells, is crucial for effective tissue repair. Overall, this study an efficient strategy constructing micropattern hydrogels, providing bioactive platform that significantly enhances
Language: Английский
Citations
1
Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1845 - 1845
Published: Nov. 18, 2024
Over the past two decades, research on innovative micro- and nano-biomaterials has seen a significant surge in bioengineering, biomedicine, regenerative medicine fields [...].
Language: Английский
Citations
0