Biomimetic multilayered polymeric heart valve featuring ultra-thin thickness and exceptional durability

Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 756, P. 151609 - 151609

Published: March 8, 2025

Language: Английский

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Sudden cardiac death and heart valves pathology

Minerva Forensic Medicine, Journal Year: 2025, Volume and Issue: 144(4)

Published: March 1, 2025

Language: Английский

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Polymeric Heart Valves

JACC Advances, Journal Year: 2025, Volume and Issue: 4(6), P. 101761 - 101761

Published: May 1, 2025

Language: Английский

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Global Hotspots and Development Trends in the New Generation of Artificial Heart Valves: A Bibliometric Analysis from 1991 to 2024

Published: Jan. 1, 2025

Valvular heart disease (VHD) is a major cause of morbidity and mortality worldwide. To address the limitation clinically available valve prostheses, new-generation artificial valves (AHVs) have experienced tremendous technical evolution could become promising therapeutic alternative. This paper aims to explore research foundation, hotspots, trends in field AHVs last three decades from perspective structural temporal dynamics. The 1,314 publications total were indexed Web Science serving as sample; while bibliometric analysis was conducted by utilizing Citespace software for detecting visualizing. presented steadily increasing publications, close collaboration between countries, institutions, authors, disciplines, which led continuously evolving hotspots reflected burst analysis. Three active clusters, namely VHD (aortic stenosis infective endocarditis), tissue engineered (decellularization, cells nanofiber) polymeric (polyurethane special design). It demonstrated that classical concepts engineering, extracellular matrix calcification; emerging hotpots included immune response, hydrogels, elastomeric scaffolds, trilayered, transcatheter; latest keywords 3D printing fluid-structure interaction. According objective results analysis, we summarized more focus should be put on pathological mechanisms explants analysis; challenges future directions exploration new synthetic materials composite materials, multi-scale accurate structure design, rapid customized manufacture, modulating along with numerical simulation experimental validation.

Language: Английский

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A Retrospective Analysis of Standardized Gradient Calculations for Evaluating Patient–Prosthesis Mismatch Following Mechanical Aortic Valve Replacement

Diagnostics, Journal Year: 2025, Volume and Issue: 15(5), P. 567 - 567

Published: Feb. 26, 2025

Background: Aortic stenosis (AS) is one of the most common valvular heart diseases, particularly in elderly, with a prevalence approximately 3% individuals over 75 years age. valve replacement (AVR) remains standard treatment, yet postoperative hemodynamic assessment often complicated by variations prosthetic size, left ventricular ejection fraction (LVEF), effective orifice area (EOA), and body surface (BSA). These factors significantly influence function contribute to patient-prosthesis mismatch (PPM), which has been associated worse clinical outcomes. Traditional transvalvular gradient measurements fail account for these patient-specific variables. This study introduces novel approach standardized calculations, aiming enhance accuracy comparability assessments. Methods: A retrospective analysis was conducted on 115 patients who underwent mechanical AVR at single center. Patients were categorized into three groups based type: St. Jude Medical (SJM) HP (n = 31); SJM Regent 54); those aortic root enlargement (ARE) 30). Preoperative transthoracic echocardiography (TTE) performed measure conventional gradients. Four calculations developed adjust individual differences, improving assessment. Results: Standardized demonstrated significant differences between prosthesis types. Postoperative gradients higher group compared aortic-root-enlargement (p < 0.001, p 0.05). The lowest observed received prostheses Although showed no revealed that 19 mm exhibited than 21 0.05), emphasizing importance size hemodynamics. Conclusions: provide more objective, reliable, minimizing interpatient variability. improves detection optimizes evaluation, potentially leading better selection surgical decision-making. However, further validation required larger cohorts before methods can be widely adopted practice. Future studies should assess their impact long-term outcomes, including remodeling patient survival.

Language: Английский

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Transcatheter bicuspid venous valve prostheses: fluid mechanical performance testing of artificial nonwoven leaflets

BioMedical Engineering OnLine, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 29, 2024

Abstract Background Chronic venous insufficiency (CVI) is a common disease with high prevalence. Incompetent valves are considered as one of the main causes. Besides compression therapy, various surgical therapies practiced, whereby reconstruction central importance. There an unmet clinical need, no valve prosthesis commercially available to date. This work introduces two versions patented prosthetic bicuspid design made electrospun thermoplastic silicone polycarbonate polyurethane (TSPCU) nanofiber leaflets attached in nitinol stent, and their performance static pulsatile operation. Results The mainly fulfill requirements widely accepted literature. Valves both were functional physiological pressure range up 50 mmHg specific differences. Conclusions here introduced act platform technology can be tailored for intended implantation site. Evaluation original modified concept demonstrated efficacy, limitations at higher loads design. At current state, modification preferable fabrication, processing step eliminated. Moreover, recommendations could drawn similar basic structure. Future will focus on long-term biocompatibility prior initiation preclinical vivo studies.

Language: Английский

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А Novel Polymer Film to Develop Heart Valve Prostheses

Polymers, Journal Year: 2024, Volume and Issue: 16(23), P. 3373 - 3373

Published: Nov. 29, 2024

Polymer heart valves are a promising alternative to bioprostheses, the use of which is limited by risks calcific deterioration devitalized preserved animal tissues. This especially relevant in connection with increasingly widespread transcatheter valves. Advances modern organic chemistry provide wide range polymers that can replace biological material production valve prostheses. In this work, main properties REPEREN

Language: Английский

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