Cellulose-Based Ionic Conductor: An Emerging Material toward Sustainable Devices

Chemical Reviews, Journal Year: 2023, Volume and Issue: 123(15), P. 9204 - 9264

Published: July 7, 2023

Ionic conductors (ICs) find widespread applications across different fields, such as smart electronic, ionotronic, sensor, biomedical, and energy harvesting/storage devices, largely determine the function performance of these devices. In pursuit developing ICs required for better performing sustainable cellulose appears an attractive promising building block due to its high abundance, renewability, striking mechanical strength, other functional features. this review, we provide a comprehensive summary regarding fabricated from cellulose-derived materials in terms fundamental structural features cellulose, design fabrication techniques engineering, main properties characterization, diverse applications. Next, potential cellulose-based relieve increasing concern about electronic waste within frame circularity environmental sustainability future directions be explored advancing field are discussed. Overall, hope review can unique perspectives on application advanced thereby encourage utilization cellulosic toward

Language: Английский

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Tunable Polydopamine Coating: Surface Modification of Polymer Bonded Explosives to Enhance Thermal Stability and Combustion Performance

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2025, Volume and Issue: unknown, P. 136118 - 136118

Published: Jan. 1, 2025

Language: Английский

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Underground hydrogen storage in reservoirs: pore-scale mechanisms and optimization of storage capacity and efficiency

Applied Energy, Journal Year: 2023, Volume and Issue: 337, P. 120901 - 120901

Published: March 6, 2023

Language: Английский

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Micro‐Engineered Organoid‐on‐a‐Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients

Advanced Science, Journal Year: 2023, Volume and Issue: 10(27)

Published: July 23, 2023

Abstract Hepatocellular carcinoma (HCC) is one of the most lethal cancers worldwide. Patient‐derived organoid (PDO) has great potential in precision oncology, but low success rate, time‐consuming culture, and lack tumor microenvironment (TME) limit its application. Mesenchymal stromal cells (MSC) accumulate primary site to support growth recruit immune form TME. Here, MSC peripheral blood mononuclear (PBMC) coculture used construct HCC organoid‐on‐a‐chip mimicking original TME provide a high‐throughput drug‐screening platform predict outcomes anti‐HCC immunotherapies. HCC‐PDOs PBMC are co‐cultured with Cancer‐associated fibroblasts (CAF). increases rate biopsy‐derived PDO accelerates growth, promotes monocyte survival differentiation into tumor‐associated macrophages. A multi‐layer microfluidic chip designed achieve co‐culture for drug screening. Compared conventional PDOs, MSC‐PDO‐PBMC CAF‐PDO‐PBMC models show comparable responses chemotherapeutic or targeted anti‐tumor drugs more precise prediction assessing patients’ anti‐PD‐L1 drugs. Moreover, this shortens time improves dimensional uniformity organoids. In conclusion, study successfully constructs microengineered mimic screening, providing novel immunotherapy response patients.

Language: Английский

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Droplet-Based Microfluidics: Applications in Pharmaceuticals

Pharmaceuticals, Journal Year: 2023, Volume and Issue: 16(7), P. 937 - 937

Published: June 28, 2023

Droplet-based microfluidics offer great opportunities for applications in various fields, such as diagnostics, food sciences, and drug discovery. A droplet provides an isolated environment performing a single reaction within microscale-volume sample, allowing fast with high sensitivity, throughput, low risk of cross-contamination. Owing to several remarkable features, droplet-based microfluidic techniques have been intensively studied. In this review, we discuss the impact microfluidics, particularly focusing on screening development. addition, surveyed methods device fabrication generation/manipulation. We further highlight some promising studies covering synthesis delivery that were updated last 5 years. This review researchers quick guide includes most up-to-date relevant information latest scientific findings development pharmaceutical field.

Language: Английский

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Microfluidics: a concise review of the history, principles, design, applications, and future outlook

Biomaterials Science, Journal Year: 2023, Volume and Issue: 12(2), P. 218 - 251

Published: Nov. 27, 2023

This review offers a reliable platform for comprehending microfluidics, covering key concepts, historical advancements, technological evolution, materials, successful implementations, applications, market trends, and future prospects.

Language: Английский

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Pulsatile pressure enhanced rapid water transport through flexible graphene nano/Angstrom-size channels: a continuum modeling approach using the micro-structure of nanoconfined water

New Journal of Physics, Journal Year: 2023, Volume and Issue: 25(10), P. 103024 - 103024

Published: Oct. 1, 2023

Abstract Several researchers observed a significant increase in water flow through graphene-based nanocapillaries. As graphene sheets are flexible (Wang and Shi 2015 Energy Environ. Sci. 8 790–823), we represent nanocapillaries with deformable channel-wall model by using the small displacement structural-mechanics perturbation theory presented Gervais et al (2006 Lab Chip 6 500–7), Christov (2018 J. Fluid Mech. 841 267–86), respectively. We assume lubrication assumption shallow nanochannels, microstructure of confined along slip at capillary boundaries disjoining pressure (Neek-Amal 2018 Appl. Phys. Lett. 113 083101), derive for nanochannels. Our derived also facilitates dynamics Newtonian fluids under different conditions as its limiting cases, which have been previously reported literature 083101; 2006 500–7; 267–86 ; White 1990 Mechanics Keith Batchelor 1967 An Introduction to Dynamics Kirby 2010 Micro-and Nanoscale Mechanics: Transport Microfluidic Devices ). compare experimental observations Radha (2016 Nature 538 222–5) MD simulation results Neek-Amal 083101) our deformable-wall model. find that channel-height H o < 4 Å, flow-rate prediction is 5%–7% more compared well-fitted rigid-wall These predictions within errorbar data shown 222–5), indicates could be accurate experiments Using model, study effect flexibility on rate. α increases (or corresponding thickness $\mathcal{T}$?> T elastic modulus E wall decreases), rate increases. scales $\dot{m}_{\text{flexible}}\sim \alpha^0 $?> m ˙ flexible ∼ α 0 $(\alpha \Delta pW/EH_o) \ll 1$?> ( mathvariant="normal">Δ p W / E stretchy="false">) ≪ 1 \alpha pW/EH_o ) \sim O(10^{-1})$?> O 10 − \alpha^3 3 O(1)$?> , that, given percentage change smaller height channel than larger channels. decreases reservoir thickness, $\Delta \dot{m}/\dot{m}$?> $H_o^{-1}$?> followed $H_o^{-3}$?> after height-threshold. Further, investigate how applied pulsating influences due oscillatory field, there no averaged mass channel, whereas channels increasing magnitude field. Also, channels, depending either steady or both kinds dependence varies from p$?> p^4$?> field The $\dot{m}_{\text{rigid}}\sim p rigid it scale $ (\alpha \approxeq 0$?> Δ ≊ p^2 2 p^4 . sheet fields these intensify rapid nano/Angstrom-size capillaries.

Language: Английский

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Integrated microfluidic devices for point-of-care detection of bio-analytes and disease

Sensors & Diagnostics, Journal Year: 2023, Volume and Issue: 2(6), P. 1437 - 1459

Published: Jan. 1, 2023

Micro- and nanofluidics have enabled the possibility of miniaturized analytical systems, which are commonly known as lab-on-a-chip (LOC) devices.

Language: Английский

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Shear-Thinning Fluid Droplets Formation in Axisymmetric Flow-Focusing Microfluidics

Industrial & Engineering Chemistry Research, Journal Year: 2024, Volume and Issue: 63(8), P. 3766 - 3779

Published: Feb. 19, 2024

The formation of shear-thinning fluid [sodium alginate (SA) solution] droplets in a continuous Newtonian phase is studied numerically. influences shear thinning effects on the interface evolution, flow regimes, droplet size, and frequency are examined. A regime diagram summarized terms Capillary number (Ca) concentration (cnN-f, SA solution). results show that transition from dripping to jetting caused by increasing Ca delayed when dispersed fluid, which advantageous production highly monodispersed droplets. Additionally, cnN-f shows distinct influence regimes. In decreased size with high frequency. This study provides theoretical reference for preparation also helpful clarifying mechanism non-Newtonian

Language: Английский

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Automated Laser-Assisted Single-Cell Sorting for Cell Functional and RNA Sequencing

ACS Sensors, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Accurate and efficient sorting of single target cells is crucial for downstream single-cell analysis, such as RNA sequencing, to uncover cellular heterogeneity functional characteristics. However, conventional techniques, manual micromanipulation or fluorescence-activated cell sorting, do not match current demands are limited by low throughput, efficiency precision, viability. Here, we report an automated, highly sorter, integrating laser-induced forward transfer (LIFT) with a high-throughput picoliter micropore array. The array was surface-functionalized manipulate liquid surface tension, facilitating the formation droplets in micropores realize automated (>80%) isolation. Using in-house built microscopic system, rare were identified automatically retrieved LIFT precise (about 100%) analysis while maintaining high viability 80%). As case demonstration, demonstrated accurate transfected PC-9 post-transfection culture, minimizing loss risk contamination. Furthermore, performed sequencing showed that high-quality transcriptome information efficiently reliably obtained during preventing additional costs due accuracy. sorter will become invaluable laying foundation multiomics precision medicine research.

Language: Английский

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