Natural Products in Wound Regeneration DOI
Nallely Álvarez-Santos,

Rocío Serrano-Parrales,

Patricia Guevara

et al.

Recent advances in biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 115 - 136

Published: March 12, 2024

The skin is the largest organ in body that provides protection. When a wound occurs, structure and its function are damaged, it can even compromise life. Damage repair occur through two mechanisms: healing regeneration. scar forms, fibrosis occurs area, appendages, which include glands hair follicles, lost. In regeneration, functionality of partially or totally recovered. Medicinal plants their active principles favor regeneration wounds because they have direct effects on different phases process. They hemostasis, modulate inflammation, allows following stages to less time, such as proliferation remodeling. time (proliferation remodeling). Natural products also reduce risk infections by having antibacterial activity. However, bioavailability extracts metabolites may be limited, solution this problem integrate them into preparations hydrogels, nanoparticles, nanofibers, nanoemulsions. Research therapeutic properties various natural integration formulations mentioned above for described below according effect epithelialization, epidermal vascularization, some cases mechanism action.<br>

Language: Английский

Green Synthesis of Metal and Metal Oxide Nanoparticles: A Review of the Principles and Biomedical Applications DOI Open Access
Denisa-Maria Radulescu, Vasile-Adrian Surdu, Anton Ficai

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15397 - 15397

Published: Oct. 20, 2023

In recent years, interest in nanotechnology has increased exponentially due to enhanced progress and technological innovation. tissue engineering, the development of metallic nanoparticles been amplified, especially their antibacterial properties. Another important characteristic metal NPs is that they enable high control over features developed scaffolds (optimizing mechanical strength offering controlled release bioactive agents). Currently, main concern related method synthesis oxide environmental impact. The physical chemical uses toxic agents could generate hazards or exert carcinogenicity/environmental toxicity. Therefore, a greener, cleaner, more reliable approach needed. Green synthetic come as solution counter aforementioned limitations. Nowadays, green preferred because it leads prevention/minimization waste, reduction derivatives/pollution, use non-toxic (safer) solvents. This not only biomass sources reducing for salts. biomolecules also cover synthesized act situ capping agents. Further, involvement formation process reduces toxicity, prevents nanoparticle agglomeration, improves antimicrobial activity nanomaterial, leading possible synergistic effect. study aims provide comprehensive review nanoparticles, from routes, selected solvents, parameters latest application biomedical field.

Language: Английский

Citations

87

A Mechanistic Overview on Green Assisted Formulation of Nanocomposites and Their Multifunctional Role in Biomedical Applications DOI Creative Commons

Mahnoor Mahnoor,

Khafsa Malik, Abeer Kazmi

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654

Published: Jan. 8, 2025

The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.

Language: Английский

Citations

2

Multifunctional chitosan/carbon dots/sodium alginate/zinc oxide double-layer sponge hydrogel with high antibacterial, mechanical and hemostatic properties DOI Creative Commons

Reza Monfared-Hajishirkiaee,

Hamide Ehtesabi,

Shima Najafinobar

et al.

OpenNano, Journal Year: 2023, Volume and Issue: 12, P. 100162 - 100162

Published: May 10, 2023

Due to the fact that bacterial contamination of wounds is cause increased morbidity and mortality today, various antimicrobial wound dressings are developing prevent contamination. In addition, an ideal dressing should have proper mechanical hemostatic properties maintain healing conditions. Here, a double-layer sponge hydrogel nanocomposite was designed manufactured by combining zinc oxide nanoparticles (ZnONPs) with different concentrations in layer green carbon dots layer. The surface morphology two layers investigated using scanning electron microscope. X-ray diffraction proved presence ZnONPs. Physical tests showed decrease water absorption vapor transmission rate increase blood ZnO. suitable support dots. By both layers, were greatly enhanced. highest concentration ZnO excellent inhibition 41 mm against Pseudomonas aeruginosa bacteria 25 Staphylococcus aureus. Finally, vitro clotting animal confirmed power maximum

Language: Английский

Citations

26

Silk fibroin-based scaffolds for wound healing applications with metal oxide nanoparticles DOI Creative Commons
Denisa-Maria Radulescu, Ecaterina Andronescu, Otilia Ruxandra Vasile

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 96, P. 105689 - 105689

Published: April 21, 2024

In the last few years, wound healing and development of "ideal" biomaterials that provide quick recovery minimize scarring have represented one most important priorities researchers. this direction, silk fibroin (SF) scaffolds gained substantial awareness, as a promising polymer owing to their increased biocompatibility, outstanding mechanical properties, biodegradability, especially tensile strength. Furthermore, SF is acknowledged accelerate process by encouraging cell growth proliferation, also migration different types cells are included in stages process. Therefore, metal oxide nanoparticles (NPs), such iron (FeO), copper (CuO), zinc (ZnO), or magnesium (MgO) NPs, been extensively researched for antimicrobial properties ability enhance tissue regeneration addition SF. When introduced within scaffolds, these NPs impart enhanced including improved scaffold stability durability. Moreover, presence could increase biocompatibility facilitating adhesion, migration, ultimately promoting processes. The incorporation other natural polymers into has thus emerged favorable method therapeutic potential developed biomaterial. This review aims an overview advancements containing applications.

Language: Английский

Citations

14

Green Nanomaterials for Smart Textiles Dedicated to Environmental and Biomedical Applications DOI Open Access

Melania Popescu,

Camelia Ungureanu

Materials, Journal Year: 2023, Volume and Issue: 16(11), P. 4075 - 4075

Published: May 30, 2023

Smart textiles recently reaped significant attention owing to their potential applications in various fields, such as environmental and biomedical monitoring. Integrating green nanomaterials into smart can enhance functionality sustainability. This review will outline recent advancements incorporating for applications. The article highlights nanomaterials’ synthesis, characterization, textile development. We discuss the challenges limitations of using future perspectives developing environmentally friendly biocompatible textiles.

Language: Английский

Citations

17

Multifunctional polyvinyl alcohol/poly-dopamine hydrogels loaded with bio-nano composites promote wound healing by repairing endogenous electric fields DOI

Yueyuan Zhu,

Xiuwen Zhang, Li Ren

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 272, P. 132763 - 132763

Published: May 29, 2024

Language: Английский

Citations

6

Plant-Based nanostructure for wound healing – An emerging paradigm for effective therapy DOI

Tamilselvan Amutha Gokul,

Kamatchi Ramesh Kumar,

Karthikeyan Venkatachalam

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 162, P. 112162 - 112162

Published: Feb. 6, 2024

Language: Английский

Citations

5

Synthesis of multifunctional bilayer wound dressing using Alyssum homalocarpum seed mucilage, Sambucus ebulus plant extract and zinc oxide nanoparticles DOI Creative Commons

Sajede Jam,

Mohammad Ashfaq, Mansour Ghorbanpour

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 226, P. 120678 - 120678

Published: Feb. 13, 2025

Language: Английский

Citations

0

Plant-based nanomaterials: an effective wound healing medicine DOI

Tamilselvan Amutha Gokul,

Kamatchi Ramesh Kumar,

Veeramani Veeramanikandan

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 17 - 27

Published: Jan. 1, 2025

Language: Английский

Citations

0

Wound healing approaches based on polysaccharide-nanoparticles biocomposites DOI
Patrícia Concórdio‐Reis,

João R. Pereira,

Asiyah Esmail

et al.

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 69 - 97

Published: Jan. 1, 2025

Language: Английский

Citations

0