Nanobiomaterials: exploring mechanistic roles in combating microbial infections and cancer DOI Creative Commons

Neha Rawat,

Nabeel Ahmad,

Pratishtha Raturi

et al.

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 20, 2023

The initiation of the "nanotechnology era" within past decade has been prominently marked by advancements in biomaterials. This intersection opened up numerous possibilities for enhancing detection, diagnosis, and treatment various illnesses leveraging synergy between biomaterials nanotechnology. term "nano biomaterials" referring to featuring constituent or surface feature sizes below 100 nm, presents a realm extraordinary materials endowed with unique structures properties. Beyond addressing common biomedical challenges, these nano contribute unprecedented insights principles that enrich our understanding biology, medicine, science. A critical evaluation recent technological progress employing medicine is essential, along an exploration potential future trends. Nanotechnology breakthroughs have yielded novel surfaces, materials, configurations notable applications domain. integration nanotechnology already begun enhance traditional practices across diverse fields such as tissue engineering, intelligent systems, utilization nanocomposites implant design, controlled release biosensors, more. mini review encapsulates into biomaterials, encompassing their types, synthesis methods, roles organic inorganic nanoparticles, elucidating mechanisms action. Furthermore, focus squarely placed on versatile applications, particular emphasis anticancer antimicrobial interventions. underscores dynamic landscape nanotechnology, envisioning where play pivotal role advancing medical particularly combating cancer microbial infections.

Language: Английский

Innovative Strategies for Upcycling Agricultural Residues and Their Various Pharmaceutical Applications DOI Creative Commons

Ludovic Everard Bejenaru,

Antonia Radu, Adina‐Elena Segneanu

et al.

Plants, Journal Year: 2024, Volume and Issue: 13(15), P. 2133 - 2133

Published: Aug. 1, 2024

This review investigates innovative strategies for upcycling agricultural residues into valuable pharmaceutical compounds. The improper disposal of contributes to significant environmental issues, including increased greenhouse gas emissions and ecosystem degradation. Upcycling offers a sustainable solution, transforming these high-value bioproducts (antioxidants, antitumor agents, antidiabetic compounds, anti-inflammatory antiviral drugs). Nanotechnology microbial biotechnology have crucial role in enhancing bioavailability targeted delivery bioactive Advanced techniques like enzymatic hydrolysis, green solvents, microwave processing, pyrolysis, ultrasonic acid alkaline ozonolysis, organosolv processes are explored their effectiveness breaking down waste extracting Despite the promising potential, challenges such as variability residue composition, scalability, high costs persist. emphasizes need future research on cost-effective extraction robust regulatory frameworks ensure safety, efficacy, quality bioproducts. represents viable path towards management production contributing conservation public health improvements. provides an analysis current literature identifies knowledge gaps, offering recommendations studies optimize use drug industry.

Language: Английский

Citations

6
Biocompatible Hollow Gadolinium Oxide Nanocarriers for the Transport of Bioactive Molecules to Cells DOI
Shifaa M. Siribbal, Anna Jurewicz,

Menna Hassan

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(11), P. 12408 - 12419

Published: May 23, 2024

Integrating imaging and therapeutic capabilities into a single entity can offer enhanced diagnostic accuracy treatment efficacy in clinically effective formulations. Due to the diversity of chemical structures and/or limited solubility inhibitors or fluorophores, it is essential employ robust delivery carrier that facilitate drug absorption distribution during its circulation blood. This study explores potential hollow gadolinium oxide (Gd2O3) nanocarriers applications. The citric acid (CA)-capped were synthesized via urea-assisted precipitation hydrothermal methods using carbon spheres as sacrificial templates. resulting nanosized displayed spherical morphology demonstrated relaxation rates longitudinal transverse directions, indicated by their r1 r2 values 1.8 5.3 s–1 mM–1, respectively. To mimic physiological conditions, loaded separately with antibiotic sparfloxacin azo dye Congo red at neutral pH (7.4) body temperature (37 °C). CR-loaded nanospheres exhibited time-dependent internalization behavior HeLa cells, suggesting for intracellular delivery. Furthermore, SP-loaded antimicrobial activity against both Gram-positive Gram-negative bacteria, demonstrating bacterial infections. mitigate risk leaching Gd3+ ions inherent toxicity, CA coating was applied surface which resulted outstanding cell viability functionalized nanocarriers. In addition, offered additional support increased encapsulation continuous release molecules until 1 week (168 h). characterization data provide evidence CA-capped positive MR contrast agents applicability safe controlled carriers.

Language: Английский

Citations

5
Immunomodulatory metal-based biomaterials for cancer immunotherapy DOI

Kangzhi Yuan,

Cai Zhang,

Xiang-Ying Pan

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 249 - 268

Published: Sept. 12, 2024

Language: Английский

Citations

5
Controlled synthesis of zinc oxide nanoparticles through flame spray pyrolysis and evaluation of their anticancer effects against gastric cancer cell DOI Creative Commons

Wujun Du,

Ke Feng,

Cunji Li

et al.

Arabian Journal of Chemistry, Journal Year: 2023, Volume and Issue: 16(10), P. 105192 - 105192

Published: July 26, 2023

Although zinc oxide nanoparticles (ZnO NPs) have demonstrated promising anticancer activity, their therapeutic performances are frequently influenced by the synthesis routes and associated distinct physicochemical characteristics. Herein, ZnO NPs were synthesized through a cost-effective flame spray pyrolysis-assisted approach selective effects underlying intrinsic apoptosis signaling pathway in human gastric carcinoma cell line (AGS) examined. Transmission electron microscopy (TEM), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), dynamic light scattering (DLS) investigations used to characterize NPs. Afterwards, AGS normal fibroblast cells (L-929) treated with various concentrations of NPs, proliferation was examined MTT assay determine IC50 concentration Furthermore, quantification ROS done fluorometer flow cytometry assays. Additionally, superoxide dismutase (SOD) catalase (CAT) activity assays performed evaluate oxidative stress-induced cytotoxicity mediated against cells. Moreover, caspase-3/-8/-9 mitochondrial membrane potential (MMP) done. Finally, expression levels p53, Bax, Bcl-2, caspase-9/-8/-3, cytochrome c assessed quantitative real time PCR western blot analyses explore probable induced The results showed that an absorption maximum at 350 nm, average size 70 hydrodynamic radius 92.89 zeta −43.13 mV potentially selectively inhibited comparison L-929 remarkable increase production ROS, induction apoptosis, reduction SOD CAT activation caspase-9/-3, MMP disruption. triggered up-regulation down-regulation Bcl-2 mRNA protein levels. This study suggests pyrolysis can induce cancer via pathway.

Language: Английский

Citations

12
Supramolecular Strategy for the Design of Nanocarriers for Drugs and Natural Bioactives: Current State of the Art (A Review) DOI Creative Commons
L. Ya. Zakharova, Faniya Maganova,

Kirill Sinyashin

et al.

Russian Journal of General Chemistry, Journal Year: 2023, Volume and Issue: 93(7), P. 1867 - 1899

Published: July 1, 2023

Abstract The review focuses on the lipid based nanocarriers, with special attention paid to natural bioactive payloads. First, micelles and microemulsions are considered as very attractive colloidal nanocontainers that allow for marked improving solubility of hydrophobic bioactives. Further, liposomal vehicles reviewed, both advantages limitations discussed. Literature assay covers up-to-date information about last three five years, although brief background is given pioneer works addressing liposomes their evolution from bench bedside. Final part devoted modern modifications vesicular nanocarriers which can be adapted specific administration way due improved targeting properties, permeability, mucoadhesiveness possibility cross biological barriers. Therein, such kinds transfersomes, niosomes, ethosomes, chitosomes evaluated; separate sections focus formulations, i.e., phytosomes invasomes.

Language: Английский

Citations

11
Development of manganese cobalt oxide (MnCo2O4) nanoparticle as multifunctional agents for antibacterial, anticancer and dye degradation applications DOI

K. Tamil Thendral,

M. Amutha,

R. Ragunathan

et al.

Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112854 - 112854

Published: July 14, 2024

Language: Английский

Citations

4
Highly Efficient Ultrasound‐Assisted Synthesis, Characterization, and Antibreast Cancer (Invasive Ductal Carcinoma) of New Chalcone Based Compound and Its Nanohybrid With Silver Nanoparticles DOI

Elaf Abd Al‐Hameed Shihab,

Maysoon A. Hamad,

Batool Jubair

et al.

Macromolecular Symposia, Journal Year: 2025, Volume and Issue: 414(1)

Published: Feb. 1, 2025

Abstract In this work, indole‐3‐carboxaldehyde is used as a synthon to prepare chalcone‐based Schiff base. The reaction includes the treatment of with 1‐(4‐amino‐2‐fluorophenyl)ethanone afford ES1, which reacts paramethylthiobenzaldehyde give ES2 high yield (>95%). product characterized by FTIR, CHN, melting point, and 1 H NMR. compound decorated on silver nanoparticles nanoproduct named Ag NPs‐ES. presented nanocomposite XRD TEM, results prove that highly pure formed quasisphere within range 20–51 nm. for breast cancer cell lines (in vitro) consist 77% invasive ductal carcinoma (IDC), 10% lobular (ILC), 2% tubular carcinoma, in addition 11% papillary, medullary carcinoma. demonstrate able only viability IC 50 equal 1.726 mg/ml no toxicity normal human line (HDFn).

Language: Английский

Citations

0
Green Synthesis of Gold Nanoparticles Using Clerodendrum trichotomum Thunberg for Antibacterial and Anticancer Applications DOI Creative Commons
Adnan Shakoor, Umme Tamanna Ferdous, Shakeel Ahmad Khan

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 2645 - 2658

Published: March 1, 2025

The potential use of gold nanoparticles (AuNPs) in healthcare research has increased dramatically recent years, owing to advancements their synthesis techniques, including green synthesis. Although Clerodendrum trichotomum is a popular medicinal plant that harbors many bioactive phytochemicals various parts the world, AuNPs using this precious still under investigation. Therefore, study aimed explore from C. Thunberg leaves (CTT-AuNPs) and antibacterial cytotoxic properties. were synthesized characterized microscopic spectroscopic techniques. A serial dilution technique was used determine activity CTT-AuNPs against two bacterial species, Klebsiella pneumoniae Staphylococcus aureus. cytotoxicity assay carried out breast cancer cell line (MCF-7), whereas biocompatibility test performed kidney (293T). Multiple characterization techniques confirmed successful CTT-AuNPs. average size 19.1±2.2 nm. results revealed showed strong S. aureus K. pneumoniae, which further live/dead dual staining assay. also significantly reduced proliferation MCF-7 cells 32.67% at 120 µg/mL after 24 hours incubation. These green-synthesized exhibited excellent cytobiocompatibility with 293T cells. method compared chemically AuNPs. This work will pave way for production biocompatible can be different disease treatments.

Language: Английский

Citations

0
The current use of nanotechnology in the fight against antimicrobial resistance: promising approaches to global health challenge DOI
Gideon Sadikiel Mmbando,

Ombeni Ally,

Shedrack Reuben Kitimu

et al.

Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)

Published: April 1, 2025

Language: Английский

Citations

0
Nanoparticles of banana peels as a potential source of bioactive compounds and their activities on HepG2 DOI Creative Commons

Donia S. Hassanin,

Sahar R. Abdelhady,

Adel Kh. Ghazi

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 5, 2025

Abstract Nanoparticles of blanched green banana peels (BGBP) were prepared using physical technique (by grinding) in order to avoid any harm effect on human health that could occurred when metals used for preparing nanoparticles size (NPs) peels. This work was designed study the preparation nano scale (70–135 nm TEM) (243.4–933.9 SEM) and normal (0.12–0.25 µm (1.150 from BGBP after milling evaluate activities their extracts as antioxidant, antimicrobial anticancer agents. The shape analyzed Scanning Electron Microscope (SEM) it cleared appearance particle aggregation attributed mechanical pressure friction resulting interaction between abrasive balls pulverizing vessel’s inner surface. Also, Transmission (TEM) shows presence different spherical shapes ranging 70 135 nm, along with emergence slender fibrillary shapes., other hand, Fourier transform IR (FT-IR) higher extraction yields phenolic compounds greater antioxidant achieved due increased surface area nano-scale samples following milling. In addition, X-ray diffraction (XRD) determined materials crystalline structure. Bioactive (mainly compounds) recovered by extracting weather or (NPs). extracted bioactive subjected evolution Dealing this study, concluded NPS showed than those ones. So, is strongly recommended use NPs producing these since are important protect humans against a lot dangerous diseases. Finally, potential applications pharmaceutical food industries would be beneficial.

Language: Английский

Citations

0