Halide perovskites for high-performance X-ray detector

Materials Today, Journal Year: 2021, Volume and Issue: 48, P. 155 - 175

Published: Feb. 27, 2021

Language: Английский

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Ceramic Wafer Scintillation Screen by Utilizing Near‐Unity Blue‐Emitting Lead‐Free Metal Halide (C₈H₂₀N)₂Cu₂Br₄

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(5)

Published: Nov. 18, 2022

Abstract Scintillators with high light yield, low detection limit, large X‐ray attenuation efficiency as well stable and nontoxic compositions are of great importance for radiation applications. Here, 0D (C 8 H 20 N) 2 Cu Br 4 single crystals obtained show blue emission peaking at 468 nm a near‐unity photoluminescence quantum yield 99.7%, Stokes shift 148 (i.e., negligible self‐absorption), good environmental stability along strong absorption capability. Moreover, up to ≈ 91 300 photons/MeV limit 52.1 nGy air s −1 realized, which is more than one hundred times lower the dose rate 5.5 µGy required medical diagnostics. ceramic wafer scintillation screen fabricated by cold pressing sintering process, clear contrast images opaque metal box electronic component spatial resolution 9.54 lp mm realized. This study not only designs new lead‐free halide scintillator, but also develops universal strategy preparation large‐sized scintillator in nondestructive imaging.

Language: Английский

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Deep Learning for Medical Image-Based Cancer Diagnosis

Cancers, Journal Year: 2023, Volume and Issue: 15(14), P. 3608 - 3608

Published: July 13, 2023

(1) Background: The application of deep learning technology to realize cancer diagnosis based on medical images is one the research hotspots in field artificial intelligence and computer vision. Due rapid development methods, requires very high accuracy timeliness as well inherent particularity complexity imaging. A comprehensive review relevant studies necessary help readers better understand current status ideas. (2) Methods: Five radiological images, including X-ray, ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), positron emission (PET), histopathological are reviewed this paper. basic architecture classical pretrained models comprehensively reviewed. In particular, advanced neural networks emerging recent years, transfer learning, ensemble (EL), graph network, vision transformer (ViT), introduced. overfitting prevention methods summarized: batch normalization, dropout, weight initialization, data augmentation. image-based analysis sorted out. (3) Results: Deep has achieved great success diagnosis, showing good results image classification, reconstruction, detection, segmentation, registration, synthesis. However, lack high-quality labeled datasets limits role faces challenges rare multi-modal fusion, model explainability, generalization. (4) Conclusions: There a need for more public standard databases cancer. pre-training potential be improved, special attention should paid multimodal fusion supervised paradigm. Technologies such ViT, few-shot will bring surprises images.

Language: Английский

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Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 19691 - 19721

Published: Nov. 15, 2022

The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration the visible-light excitation. X-ray-induced (X-PDT) has been proven to be a successful technique reforming conventional PDT deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and witnessed rapid developments over past several years. Beyond proof-of-concept demonstration, recent advances X-PDT have exhibited trend minimizing X-ray radiation doses quite low values. As such, scintillating materials used bridge photosensitizers play significant role, do diverse well-designed irradiation modes smart strategies improving tumor microenvironment. Here this review, we provide comprehensive summary achievements highlight trending efforts using radiation. We first describe concept relationships with radiodynamic radiotherapy then dissect mechanism absorption conversion materials, reactive oxygen species evaluation X-PDT, side effects clinical concerns on Finally, discuss detailed overview progress regarding low-dose present perspectives possible translation. It is expected that pursuit will facilitate breakthroughs, both fundamentally clinically, effective treatment near future.

Language: Английский

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Next generation lanthanide doped nanoscintillators and photon converters

eLight, Journal Year: 2022, Volume and Issue: 2(1)

Published: Sept. 19, 2022

Abstract Scintillators are of significance for the realization indirect X-ray detection and excited optical luminescence (XEOL) imaging. However, commercial bulk scintillators not only require complex fabrication procedures, but also exhibit non-tunable XEOL wavelength poor device processability. Moreover, thick crystals usually generate light scattering followed by evident signal crosstalk in a photodiode array. Lanthanide doped fluoride nanoscintillators (NSs) prepared with low-temperature wet-chemical method possess several advantages, such as low toxicity, cheap cost, convenient processability adjustable emission wavelengths from ultraviolet to visible extending second near infrared window. In addition, they long persistent (XEPL) making them suitable broadening scope their applications. This review discusses summarizes XEPL characteristics lanthanide NSs. We discuss design strategies nanostructures that allow manipulation excitation dynamics core–shell geometry simultaneously produce XEOL, XEPL, well photon upconversion downshifting, enabling at multiple varying time scale profile. The ends discussion existing challenges advancing this field, presents our subjective insight into areas further multidisciplinary opportunities.

Language: Английский

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An Alkaline Phosphatase-Responsive Aggregation-Induced Emission Photosensitizer for Selective Imaging and Photodynamic Therapy of Cancer Cells

ACS Nano, Journal Year: 2023, Volume and Issue: 17(8), P. 7145 - 7156

Published: April 17, 2023

Fluorescence-guided photodynamic therapy (PDT) has been considered as an emerging strategy for precise cancer treatment by making use of photosensitizers (PSs) with reactive oxygen species (ROS) generation. Some efficient PSs have reported in recent years, but multifunctional that are responsive to cancer-specific biomarkers rarely reported. In this study, we introduced a phosphate group biomarker alkaline phosphatase (ALP) on PS the features aggregation-induced emission (AIE) cell imaging and therapy. cells high ALP expression, AIE probe is selectively hydrolyzed ALP. Consequently, hydrophobic residue aggregated aqueous media gives "turn on" fluorescent response. Moreover, fluorescence-guided PDT was realized aggregates strong ROS generation efficiency under white light irradiation. Overall, work presents applying ALP-responsive specific succeeding upon stimulated reactions.

Language: Английский

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Improving X-ray Scintillating Merits of Zero-Dimensional Organic–Manganese(II) Halide Hybrids via Enhancing the Ligand Polarizability for High-Resolution Imaging

Nano Letters, Journal Year: 2023, Volume and Issue: 23(10), P. 4351 - 4358

Published: May 8, 2023

Luminescent metal halides have been exploited as a new class of X-ray scintillators for security checks, nondestructive inspection, and medical imaging. However, the charge traps hydrolysis vulnerability are always detrimental to three-dimensional ionic structural scintillators. Here, two zero-dimensional organic-manganese(II) halide coordination complexes 1-Cl 2-Br were synthesized improvements in scintillation. The introduction polarized phosphine oxide can help increase stabilities, especially self-absorption-free merits these Mn-based hybrids. dosage rate detection limits reached up 3.90 0.81 μGyair/s 2-Br, respectively, superior diagnostic standard 5.50 μGyair/s. fabricated scintillation films applied radioactive imaging with high spatial resolutions 8.0 10.0 lp/mm, holding promise use

Language: Английский

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Micro/Nano Perovskite Materials for Advanced X-ray Detection and Imaging

ACS Nano, Journal Year: 2024, Volume and Issue: 18(8), P. 6095 - 6110

Published: Feb. 19, 2024

Halide perovskites have emerged as highly promising materials for ionizing radiation detection due to their exceptional characteristics, including a large mobility-lifetime product, strong stopping power, tunable band gap, and cost-effective crystal growth via solution processes. Semiconductor-type X-ray detectors employing various micro/nano perovskite shown impressive progress in achieving heightened sensitivity lower limits. Here, we present comprehensive review of the applications direct type detection, with focus on requirements assembly device properties advanced detectors. We explore diverse processing techniques optoelectronic considerations applied Additionally, this highlights challenges opportunities detector arrays real-world applications, potentially necessitating further research efforts.

Language: Английский

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All-inorganic perovskite nanocrystals: next-generation scintillation materials for high-resolution X-ray imaging

Nanoscale Advances, Journal Year: 2021, Volume and Issue: 4(3), P. 680 - 696

Published: Dec. 30, 2021

With super strong penetrability, high-energy X-rays can be applied to probe the inner structure of target objects under nondestructive situations. Scintillation materials down-convert into visible light, enabling reception photon signals and photoelectric conversion by common sensing arrays such as photomultiplier tubes amorphous-Si photodiode matrixes. All-inorganic perovskite nanocrystals are emerging photovoltaic scintillation materials, with tremendous light-conversion efficiency tunable luminous properties, exhibiting great potential for high-quality X-ray imaging. Recent advancements in nanotechnology further accelerate performance improvement materials. In this review, we will provide a comprehensive overview novel all-inorganic nano-scintillators terms applications low-dose medical radiography. Compared conventional scintillators, merits/drawbacks, challenges, control focus article.

Language: Английский

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Realizing Simultaneous X‐Ray Imaging and Dosimetry Using Phosphor‐Based Detectors with High Memory Stability and Convenient Readout Process

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 32(31)

Published: May 18, 2022

Abstract Flexible X‐ray storage phosphor sheets are regarded as promising alternatives to conventional electronic flat‐panel detectors, enabling imaging and dosimetry in less accessible situations. However, it is a challenge develop phosphor‐based detectors with high memory stability convenient readout processes. Here, an approach realize this using radiation‐induced photoluminescence tuning (Ba 1‐ x Sr ) 2 SiO 4 :Eu phosphors demonstrated, ascribed the reduction of Eu 3+ toward 2+ . The associated spectral change accompanying color contrast response radiation dose exploited for simultaneous imaging. recorded image can be read out conveniently by regular photo camera upon UV illumination extracted during process ratiometric way via green red pixel intensity, avoiding need absolute intensity measurement. Moreover, imaged information maintained longer than 28 days plate reused detection after bleaching 420 nm illumination, exhibiting superior retention ability good cycling resistance. These results reveal great potential X‐ray‐based microbeam therapy nondestructive inspection expected stimulate research on modulated detectors.

Language: Английский

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