RSC Advances, Journal Year: 2025, Volume and Issue: 15(3), P. 2115 - 2131
Published: Jan. 1, 2025
Advancing the development of organelle-targeted small fluorescent probes by highlighting key design strategies to reveal cellular dynamics and address persistent challenges in probe design.
Language: Английский
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(5), P. 2699 - 2804
Published: Feb. 29, 2024
The ability to gain spatiotemporal information, and in some cases achieve control, the context of drug delivery makes theranostic fluorescent probes an attractive intensely investigated research topic. This interest is reflected steep rise publications on topic that have appeared over past decade. Theranostic probes, their various incarnations, generally comprise a fluorophore linked masked drug, which released as result certain stimuli, with both intrinsic extrinsic stimuli being reported. release then signaled by emergence signal. Importantly, use appropriate fluorophores has enabled not only this emerging fluorescence marker for but also provided modalities useful photodynamic, photothermal, sonodynamic therapeutic applications. In review we highlight recent work particular focus are activated tumor microenvironments. We summarize efforts develop other applications, such neurodegenerative diseases antibacterials. celebrates diversity designs reported date, from discrete small-molecule systems nanomaterials. Our aim provide insights into potential clinical impact still-emerging direction.
Language: Английский
Citations
138
Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(7), P. 4021 - 4078
Published: March 22, 2024
Fluorescence imaging is one of the most promising approaches to achieve intraoperative assessment tumor/normal tissue margins during cancer surgery. This critical improve patients' prognosis, and therefore various molecular fluorescence probes have been developed for identification lesions Among them, "activatable" that react with cancer-specific biomarker enzymes generate signals great potential high-contrast due their low background high signal amplification by enzymatic turnover. Over past two decades, activatable employing control mechanisms worldwide this purpose. Furthermore, new activities specific types cancers identified, enabling visualization sensitivity specificity. Review focuses on recent advances in design, function characteristics target also discusses future prospects field activity-based diagnostics cancer.
Language: Английский
Citations
33
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 509, P. 215786 - 215786
Published: March 20, 2024
Language: Английский
Citations
26
Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(14), P. 5615 - 5624
Published: March 28, 2024
Abnormal lipid droplets (LDs) are known to be intimately bound with the occurrence and development of cancer, allowing LDs critical biomarkers for cancers. Aggregation-induced emission luminogens (AIEgens), efficient reactive oxygen species (ROS) production performance, prime photosensitizers (PSs) photodynamic therapy (PDT) imaging. Therefore, dual-functional fluorescent probes aggregation-induced (AIE) characteristics that enable both simultaneous LD monitoring imaging-guided PDT is essential concurrent cancer diagnosis treatment. Herein, we reported a novel LD-targeting probe (TDTI) AIE which was expected realize integration through visualization treatment via PDT. We demonstrated TDTI, typical excellent photostability, could target high specificity, enables dynamic tracking in living cells, specific imaging zebrafish, differentiation cells from normal diagnosis. Meanwhile, TDTI exhibited fast ROS generation ability (achieving equilibrium within 60 s) under white light irradiation (10 mW/cm2). The cell apoptosis assay revealed effectively induced growth inhibition HeLa cells. Further, results vivo indicated had good antitumor effect on tumor-bearing mice model. Collectively, these highlight potential utility integrated cancer.
Language: Английский
Citations
26
Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 34(2)
Published: Sept. 29, 2023
Abstract In reactive‐oxygen‐species‐mediated tumor therapy, the generation and accumulation of ·OH is highly dependent on peroxidase (POD)‐like enzymatic activities antioxidant microenvironment. As noble metal nanoalloys can enhance POD‐like activity by improving electron transfer upgrading active sites, PdCu x ( = 0.6–1.2) bimetallic with optimized activity, enhanced photothermal conversion efficiency, altered glutathione (GSH) consumption ability are synthesized a facile co‐reduction method. The between Pd Cu in their new + catalytic centers contribute to “hand‐in‐hand” collaboration activities, while properties remain almost unchanged because “back‐to‐back” confrontation occurring owing excess produced surface plasmon resonance effect. Moreover, intrinsic GSH those heat from effect tilt redox steady state. Therefore, 0.9 nanoalloy show excellent resulting route, which involves electron‐enriched hydrogen peroxide heat‐enhanced /Cu 2+ ‐coupled Fenton‐like reactions. shed light mechanism responsible for enhancing offer typical model constructing next‐generation alloy nanozymes.
Language: Английский
Citations
30
Analytica Chimica Acta, Journal Year: 2023, Volume and Issue: 1289, P. 342060 - 342060
Published: Nov. 25, 2023
Language: Английский
Citations
28
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 510, P. 215863 - 215863
Published: April 5, 2024
Language: Английский
Citations
15
ACS Nano, Journal Year: 2024, Volume and Issue: 18(27), P. 17837 - 17851
Published: June 28, 2024
Currently, specific cancer-responsive fluorogenic probes with activatable imaging and therapeutic functionalities are in great demand the accurate diagnostics efficient therapy of malignancies. Herein, an all-in-one strategy is presented to realize fluorescence (FL) imaging-guided synergetic chemodynamic–photodynamic cancer by using a multifunctional alkaline phosphatase (ALP)-response aggregation-induced emission (AIE) probe, TPE-APP. By responding abnormal expression levels ALP biomarker cells, phosphate groups on AIE probe selectively hydrolyzed, accompanied situ formation strong emissive aggregates for discriminative cell over normal cells highly active quinone methide species robust activities. Consequently, activated can efficiently destroy membranes lead death within 30 min. A superior efficacy ablation demonstrated vitro vivo. The cancer-associated response-derived FL synergistic expected provide promising avenue precise image-guided therapy.
Language: Английский
Citations
15
Aggregate, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 2, 2024
Abstract Phototheranostics has garnered sustained attention due to its significant potential for revolutionizing conventional cancer treatment strategies. While being one of the most commonly employed strategies constructing phototheranostic systems by engineering integration photosensitizers (PSs) into nanosystems, nano‐PSs face challenges including complexity in preparation process, low delivery efficiency, and toxicity issues. Contrastingly, burgeoning popularity small molecule PSs characterized aggregation‐induced emission (AIE) become evident arena phototheranostics. This preference is underscored their well‐defined structures, adjustable photophysical properties, toxicity. Therefore, acquiring profound insights pioneering strides achievable through a solitary PS with AIE tumor phototheranostics paramount scientific significance. In this review, we will discuss recent progress properties diagnosis phototherapies representative examples, guided ethos “Complexity made easy”. We also look forward future development direction molecules, central objective advancing research focal emphasis on simplicity, expeditiousness, safety.
Language: Английский
Citations
10
Science China Chemistry, Journal Year: 2023, Volume and Issue: 66(11), P. 2986 - 3005
Published: Oct. 24, 2023
Language: Английский
Citations
17