Tumor-Targeting CaO2-Based Nanoparticles for Cancer Therapy DOI
Huan Liu,

Ruijie Ai,

Bizhi Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 26276 - 26286

Published: Nov. 5, 2024

Photodynamic therapy (PDT) has emerged as a promising noninvasive modality for cancer treatment. However, its therapeutic efficacy is often compromised by the inadequate oxygen supply and overexpressed glutathione (GSH) in tumor microenvironment (TME). Herein, multifunctional core–shell nanocomposite CaLI@Z-FA was constructed targeted enhanced photodynamic/photothermal synergistic against hypoxic tumors. The integration of l-Arg addresses limitation reactive species (ROS) singularity traditional PDT generating nitric oxide (NO), which synergistically enhances efficacy. Folic acid (FA) modification on surface significantly improves targeting, enhancing accumulation nanoparticles at site. Upon reaching acidic TME, ZIF-8 shell decomposed to release CaO2, generated O2 situ relieve hypoxia enhance ICG under near-infrared irradiation. Meanwhile, PDT-induced singlet (1O2) catalyzed l-Arginine oxide, sensitized depleting intracellular GSH reacted with 1O2 generate highly antitumor nitrogen species. Moreover, photothermal effect calcium overload-mediated cell death further potentiated Both vitro vivo studies demonstrated tumor-targeting property, oxidative damage, outstanding outcomes CaLl@Z-FA negligible systemic toxicity. This O2-generating GSH-depleted nanoplatform provides an effective paradigm phototherapy.

Language: Английский

Triboelectric wearable devices for accelerated wound healing DOI
He Liu,

Yanxuan Li,

Qianbu Sun

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154628 - 154628

Published: Aug. 7, 2024

Language: Английский

Citations

9
Gyro‐Multigrid Triboelectric Nanogenerator via Topological Defects Strategy for Efficiently Harvesting Low‐Grade Wave Energy DOI Open Access
Wei Gao,

Xiaobo Gao,

Juan Su

et al.

Advanced Energy Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 19, 2025

Abstract Wave energy is a promising sustainable yet to be fully exploited due the low frequency and broad‐banded wave fields, so much that difficult capture, resulting in efficiency limited power output from current many harvesters. Here, topological defect gyro‐multigrid triboelectric nanogenerator (TD‐GM‐TENG) proposed harnesses mechanical of ocean waves generate electricity promotes accumulation charge on basis realized high rotation speed under precession gravitation acceleration effects. It benefited strategy, TD‐GM‐TENG offers transfer rate 3.1 µC s −1 when can reach nearly 1000 rpm at 1 Hz. Furthermore, density reaches 90 m − 2 cycle 0.06 s, which 1.6 times higher than same kind spherical‐TENGs field harvesting. Finally, unit outputs peak 3.7 mW simulated water environment Hz demonstrates its applicability feasibility being used as distributed emergency supply offshoring observation early warning services.

Language: Английский

Citations

0
Aqueous‐Aqueous Triboelectric Nanogenerators Empowered Multifunctional Wound Healing System with Intensified Current Output for Accelerating Infected Wound Repair DOI
Weijiang Wang,

Chongyang Fu,

Yanfeng Du

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: June 19, 2024

Triboelectric nanogenerators (TENGs) have emerged as promising devices for generating self-powered therapeutic electrical stimulation over multiple aspects of wound healing. However, the challenge achieving full 100% contact in conventional TENGs presents a substantial hurdle quest higher current output, which is crucial further improving healing efficacy. Here, novel multifunctional system presented by integrating aqueous-aqueous triboelectric (A-A TENGs) with functionalized conductive hydrogel, aimed at advancing infected therapy. The A-A are founded on principle interface and efficient post-contact separation immiscible within aqueous two-phase (ATPS), enhancing charge transfer subsequently increasing performance. Leveraging this intensified demonstrates efficacies wounds both vitro vivo, including stimulating fibroblast migration proliferation, boosting angiogenesis, collagen deposition, eradicating bacteria, reducing inflammatory cells. Moreover, hydrogel ensures uniformity integrity electric field covering site, exhibits synergistic effects. With capability to realize accelerated healing, developed "A-A empowered system" presenting an excellent prospect clinical

Language: Английский

Citations

3
Device design and data processing strategies for self-powered cardiovascular sensors DOI
Zhiming Lin,

Mingjun Zou,

Yanpeng Lu

et al.

Device, Journal Year: 2025, Volume and Issue: unknown, P. 100726 - 100726

Published: March 1, 2025

Language: Английский

Citations

0
Force-Electric Biomaterials and Devices for Regenerative Medicine DOI

Shuncheng Yao,

Xi Cui, Yong Zhang

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123288 - 123288

Published: March 1, 2025

Language: Английский

Citations

0
Transdermal anti-inflammatory effects and mechanisms of hydrogel patches containing seco-iridoids from Gentiana macrophylla Pall DOI
Huan Liu, Zhong Yao, Rong Huang

et al.

Fitoterapia, Journal Year: 2025, Volume and Issue: 183, P. 106544 - 106544

Published: April 15, 2025

Language: Английский

Citations

0
Hybrid biological macromolecules spider-silk fibroin optical patches for efficient wound healing DOI

Baoyang Lin,

Kaiyi Dong,

Zhou Shu

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 135965 - 135965

Published: Sept. 1, 2024

Language: Английский

Citations

1
Tumor-Targeting CaO2-Based Nanoparticles for Cancer Therapy DOI
Huan Liu,

Ruijie Ai,

Bizhi Liu

et al.

ACS Applied Nano Materials, Journal Year: 2024, Volume and Issue: 7(22), P. 26276 - 26286

Published: Nov. 5, 2024

Photodynamic therapy (PDT) has emerged as a promising noninvasive modality for cancer treatment. However, its therapeutic efficacy is often compromised by the inadequate oxygen supply and overexpressed glutathione (GSH) in tumor microenvironment (TME). Herein, multifunctional core–shell nanocomposite CaLI@Z-FA was constructed targeted enhanced photodynamic/photothermal synergistic against hypoxic tumors. The integration of l-Arg addresses limitation reactive species (ROS) singularity traditional PDT generating nitric oxide (NO), which synergistically enhances efficacy. Folic acid (FA) modification on surface significantly improves targeting, enhancing accumulation nanoparticles at site. Upon reaching acidic TME, ZIF-8 shell decomposed to release CaO2, generated O2 situ relieve hypoxia enhance ICG under near-infrared irradiation. Meanwhile, PDT-induced singlet (1O2) catalyzed l-Arginine oxide, sensitized depleting intracellular GSH reacted with 1O2 generate highly antitumor nitrogen species. Moreover, photothermal effect calcium overload-mediated cell death further potentiated Both vitro vivo studies demonstrated tumor-targeting property, oxidative damage, outstanding outcomes CaLl@Z-FA negligible systemic toxicity. This O2-generating GSH-depleted nanoplatform provides an effective paradigm phototherapy.

Language: Английский

Citations

0