Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release DOI
Suman Basak, Tushar Kanti Das

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution

Language: Английский

Transforming cancer treatment: The potential of nanonutraceuticals DOI Creative Commons
Girish Kumar, Tarun Virmani,

Vaishnavi Chhabra

et al.

International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: 667, P. 124919 - 124919

Published: Nov. 7, 2024

Language: Английский

Citations

5
Novel Nanocarriers Microencapsulation: Current, Patents and Clinical Trials Comprehensive Review DOI Open Access

Aileen Tressa,

Anshika Singh,

Rahul Pal

et al.

Journal of Drug Delivery and Therapeutics, Journal Year: 2025, Volume and Issue: 15(4), P. 188 - 208

Published: April 15, 2025

The field of nanocarriers and microencapsulation has witnessed substantial growth, offering innovative solutions for drug delivery challenges. This comprehensive review explores the latest advancements in technologies, focusing on their applications enhancing stability, controlled release, targeted delivery. article highlights key breakthroughs, emphasizing significance addressing therapeutic inefficacies. A detailed analysis current patents underscores strides this domain, while insights into clinical trials provide a perspective translational potential these technologies. begins with fundamental overview microencapsulation, including its various types characteristics. It intermediately delves several formulation techniques associated examining developments prepared formulations, granted patents, selection marketed products. Finally, addresses future prospects challenges that lie ahead field. Keywords: microencapsulation; entrapment; microcapsules; nanocarriers; advancements.

Language: Английский

Citations

0
Zwitterionic, Stimuli-Responsive Liposomes for Curcumin Drug Delivery: Enhancing M2 Macrophage Polarization and Reducing Oxidative Stress through Enzyme-Specific and Hyperthermia-Triggered Release DOI
Suman Basak, Tushar Kanti Das

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

A zwitterionic, stimuli-responsive liposomal system was meticulously designed for the precise and controlled delivery of curcumin, leveraging enzyme-specific hyperthermic stimuli to enhance therapeutic outcomes. This platform is specifically engineered release curcumin in response phospholipase A2, an enzyme that degrades phospholipids, enabling highly targeted site-specific drug release. Mild hyperthermia (40 °C) further enhances membrane permeability activates thermosensitive carriers, optimizing delivery. Curcumin encapsulation facilitated through a combination zwitterionic electrostatic interactions, significantly improving both loading capacity efficiency. design experiments (DoE) approach employed systematically optimize lipid-to-cholesterol ratios formulation conditions. The thoroughly characterized using dynamic light scattering, zeta potential measurements, transmission electron microscopy, ensuring stability structural integrity. Notably, this effectively encapsulates hydrophobic while maintaining particle size bioactivity. In vitro studies revealed robust antioxidant anti-ROS activities, alongside excellent biocompatibility, with no cytotoxicity observed at concentrations up 2000 μg/mL. Furthermore, liposomes enhanced M2 macrophage polarization reduced oxidative stress. advanced offers promising, biocompatible solution

Language: Английский

Citations

2