Green Synthesis and Characterization of Silver Nanoparticles from Tinospora cordifolia Leaf Extract: Evaluation of Their Antioxidant, Anti-Inflammatory, Antibacterial, and Antibiofilm Efficacies

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(5), P. 381 - 381

Published: March 1, 2025

The use of metal nanoparticles is gaining popularity owing to their low cost and high efficacy. We focused on green synthesis silver (AgNPs) using Tinospora cordifolia (Tc) leaf extracts. structural characteristics Tc (TcAgNPs) were determined several advanced techniques. Pharmacological activities, including antioxidant, anti-inflammatory, antibacterial properties, evaluated through in vitro studies. In the results, change sample color from yellow brown after adding nitrate revealed TcAgNPs, UV-visible spectrum confirmed formation. X-ray diffraction studies showed presence reducing agents crystalline nature nanoparticles. Fourier-transform infrared spectra existence essential secondary metabolites, which act as reducing/capping stabilize size TcAgNPs was small (range 36-168 nm) based measurement method. Their negative zeta potential (-32.3 mV) ensured stability water suspensions. predominantly spherical, evidenced scanning electron microscopy transmission microscopy. Atomic absorption spectroscopy data further conversion into nanoparticles, thermogravimetric analysis thermal stability. significant DPPH/ABTS radical scavenging ability a concentration-dependent manner (25-100 µg/mL). Membrane lysis assays an effective anti-inflammatory activity TcAgNPs. Furthermore, potent effects against multidrug-resistant bacteria (Pseudomonas aeruginosa, Klebsiella pneumonia, Escherichia coli, Staphylococcus aureus). treatment also exhibited antibiofilm bacterial strains, manner. Our findings demonstrate green-synthesized can be developed drugs.

Language: Английский

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Nanotheranostics Revolutionizing Gene Therapy: Emerging Applications in Gene Delivery Enhancement

Journal of Nanotheranostics, Journal Year: 2025, Volume and Issue: 6(2), P. 10 - 10

Published: April 9, 2025

Nanotheranostics—where nanoscale materials serve both diagnostic and therapeutic functions—are rapidly transforming gene therapy by tackling critical delivery challenges. This review explores the design engineering of various nanoparticle systems (lipid-based, polymeric, inorganic, hybrid) to enhance stability, targeting, endosomal escape genetic payloads. We discuss how real-time imaging capabilities integrated into these platforms enable precise localization controlled release genes, improving treatment efficacy while reducing off-target effects. Key strategies overcome barriers (such as proton sponge effect photothermal disruption) achieve nuclear are highlighted, along with recent advances in stimuli-responsive that facilitate spatiotemporal control expression. Clinical trials preclinical studies demonstrate expanding role nanotheranostics managing cancer, inherited disorders, cardiovascular neurological diseases. further address regulatory manufacturing hurdles must be for widespread clinical adoption nanoparticle-based therapies. By synthesizing progress ongoing challenges, this underscores transformative potential effective, targeted, image-guided delivery.

Language: Английский

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Green preparation of fluorescence carbon nanoparticles using honey and its biomedical applications- An in vitro study

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106919 - 106919

Published: April 1, 2025

Language: Английский

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Green synthesis of silver and gold nanoparticles using seeds extract of Cichorium intybus and their comparative analysis with commercially available ointment for wound healing activity

Journal of Molecular Histology, Journal Year: 2025, Volume and Issue: 56(3)

Published: April 26, 2025

Language: Английский

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