Adenosine-modulating synthetic high-density lipoprotein for chemoimmunotherapy of triple-negative breast cancer DOI

Xiang Gong,

Chao Zheng, Ying Cai

et al.

Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 637 - 648

Published: Feb. 8, 2024

Language: Английский

Endoperoxide‐enhanced self‐assembled ROS producer as intracellular prodrugs for tumor chemotherapy and chemodynamic therapy DOI Creative Commons
Junjie Tang, Yadong Liu, Yifan Xue

et al.

Exploration, Journal Year: 2024, Volume and Issue: 4(4)

Published: Feb. 9, 2024

Abstract Prodrug‐based self‐assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and limited drug accumulation remain major challenges further clinical transformation. In this study, PSNs delivery artesunate (ARS) are demonstrated designing pH‐responsive ARS‐4‐hydroxybenzoyl hydrazide (HBZ)‐5‐amino levulinic acid (ALA) (AHA NPs) self‐supplied excellent chemotherapy CDT. The greatly improved loading capacity generation from endoperoxide bridge using electron withdrawing group attached directly C10 site artesunate. ALA ARS‐HBZ could be released AHA NPs under cleavage hydrazone bonds triggered acidic surroundings. Besides, increased heme in mitochondria, promoting lipid peroxidation anti‐tumor effects. Our study ARS through chemical modification, pointing out potential applications fields.

Language: Английский

Citations

14

A Trisulfide Bond Containing Biodegradable Polymer Delivering Pt(IV) Prodrugs to Deplete Glutathione and Donate H2S to Boost Chemotherapy and Antitumor Immunity DOI
Xinyi Li, Jing Cai, Hanchen Zhang

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 7852 - 7867

Published: March 4, 2024

The clinical application of cisplatin (CisPt) is limited by its dose-dependent toxicity. To overcome this, we developed reduction-responsive nanoparticles (NP(3S)s) for the targeted delivery a platinum(IV) (Pt(IV)) prodrug to improve efficacy and reduce NP(3S)s could release Pt(II) hydrogen sulfide (H2S) upon encountering intracellular glutathione, leading potent anticancer effects. Notably, induced DNA damage activated STING pathway, which known promoter T cell activation. Comparative RNA profiling revealed that outperformed CisPt in enhancing immunity, antitumor oxidative stress pathways. In vivo experiments showed accumulated tumors, promoting CD8+ infiltration boosting immunity. Furthermore, exhibited robust while minimizing CisPt-induced liver Overall, results indicate hold great promise translation due their low toxicity profile activity.

Language: Английский

Citations

12

Accelerating diabetic wound healing by ROS-scavenging lipid nanoparticle–mRNA formulation DOI Creative Commons
Siyu Wang, Yuebao Zhang, Yichen Zhong

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(22)

Published: May 21, 2024

Current treatment options for diabetic wounds face challenges due to low efficacy, as well potential side effects and the necessity repetitive treatments. To address these issues, we report a formulation utilizing trisulfide-derived lipid nanoparticle (TS LNP)-mRNA therapy accelerate wound healing by repairing reprogramming microenvironment of wounds. A library reactive oxygen species (ROS)-responsive TS LNPs was designed developed encapsulate interleukin-4 (IL4) mRNA. TS2-IL4 LNP-mRNA effectively scavenges excess ROS at site induces expression IL4 in macrophages, promoting polarization from proinflammatory M1 anti-inflammatory M2 phenotype site. In model db/db mice, with this significantly accelerates enhancing formation an intact epidermis, angiogenesis, myofibroblasts. Overall, platform not only provides safe, effective, convenient therapeutic strategy but also holds great clinical translation both acute chronic care.

Language: Английский

Citations

12

Tailoring carrier-free nanocombo of small-molecule prodrug for combinational cancer therapy DOI
Haonan Li,

Wenli Zang,

Zhen Mi

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 256 - 275

Published: Oct. 25, 2022

Language: Английский

Citations

33

Taxanes prodrug-based nanomedicines for cancer therapy DOI

Linlin Sun,

Pan Zhao, Menghan Chen

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 348, P. 672 - 691

Published: June 21, 2022

Language: Английский

Citations

32

A naphthalimide-based fluorescent probe with mitochondria targeting for GSH sensing and cancer cell recognition DOI

Gengjinsheng Cheng,

Jia-Mei Qin,

Xue Li

et al.

Dyes and Pigments, Journal Year: 2023, Volume and Issue: 211, P. 111089 - 111089

Published: Jan. 9, 2023

Language: Английский

Citations

23

Self-assembly of chlorogenic acid into hydrogel for accelerating wound healing DOI
Haibo Huang, Lihang Chen, Yiyang Hou

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 228, P. 113440 - 113440

Published: July 4, 2023

Language: Английский

Citations

23

Satellite‐Type Sulfur Atom Distribution in Trithiocarbonate Bond‐Bridged Dimeric Prodrug Nanoassemblies: Achieving Both Stability and Activatability DOI Open Access
Lingxiao Li, Tian Liu, Shiyi Zuo

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(4)

Published: Nov. 21, 2023

Abstract Homodimeric prodrug nanoassemblies (HDPNs) hold promise for improving the delivery efficiency of chemo‐drugs. However, key challenge lies in designing rational chemical linkers that can simultaneously ensure stability, self‐assembly and site‐specific activation prodrugs. The “in series” increase sulfur atoms, such as trisulfide bond, improve assembly stability HDPNs to a certain extent, but limits Herein, trithiocarbonate bond ( ─ SC(S)S ), with stable “satellite‐type” distribution is developed via insertion central carbon atom bonds. effectively addresses existing predicament by homodimeric prodrugs while maintaining on‐demand bioactivation. Furthermore, inhibits antioxidant defense system, leading up‐regulation cellular ROS apoptosis tumor cells. These improvements endow vivo longevity specificity, ultimately enhancing therapeutic outcomes. is, therefore, promising overcoming bottleneck efficient oncological therapy.

Language: Английский

Citations

18

A computer-aided, heterodimer-based “triadic” carrier-free drug delivery platform to mitigate multidrug resistance in lung cancer and enhance efficiency DOI
Liyan Yang, Yingying Zhang,

Yuxin Lai

et al.

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 523 - 540

Published: Aug. 14, 2024

Language: Английский

Citations

7

Tumor microenvironment stimuli-responsive lipid-drug conjugates for cancer treatment DOI
Patihul Husni, Chaemin Lim, Kyung Taek Oh

et al.

International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 639, P. 122942 - 122942

Published: April 9, 2023

Language: Английский

Citations

16