Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 637 - 648
Published: Feb. 8, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 367, P. 637 - 648
Published: Feb. 8, 2024
Language: Английский
Exploration, Journal Year: 2024, Volume and Issue: 4(4)
Published: Feb. 9, 2024
Abstract Prodrug‐based self‐assembled nanoparticles (PSNs) with tailored responses to tumor microenvironments show a significant promise for chemodynamic therapy (CDT) by generating highly toxic reactive oxygen species (ROS). However, the insufficient level of intracellular ROS and limited drug accumulation remain major challenges further clinical transformation. In this study, PSNs delivery artesunate (ARS) are demonstrated designing pH‐responsive ARS‐4‐hydroxybenzoyl hydrazide (HBZ)‐5‐amino levulinic acid (ALA) (AHA NPs) self‐supplied excellent chemotherapy CDT. The greatly improved loading capacity generation from endoperoxide bridge using electron withdrawing group attached directly C10 site artesunate. ALA ARS‐HBZ could be released AHA NPs under cleavage hydrazone bonds triggered acidic surroundings. Besides, increased heme in mitochondria, promoting lipid peroxidation anti‐tumor effects. Our study ARS through chemical modification, pointing out potential applications fields.
Language: Английский
Citations
14ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 7852 - 7867
Published: March 4, 2024
The clinical application of cisplatin (CisPt) is limited by its dose-dependent toxicity. To overcome this, we developed reduction-responsive nanoparticles (NP(3S)s) for the targeted delivery a platinum(IV) (Pt(IV)) prodrug to improve efficacy and reduce NP(3S)s could release Pt(II) hydrogen sulfide (H2S) upon encountering intracellular glutathione, leading potent anticancer effects. Notably, induced DNA damage activated STING pathway, which known promoter T cell activation. Comparative RNA profiling revealed that outperformed CisPt in enhancing immunity, antitumor oxidative stress pathways. In vivo experiments showed accumulated tumors, promoting CD8+ infiltration boosting immunity. Furthermore, exhibited robust while minimizing CisPt-induced liver Overall, results indicate hold great promise translation due their low toxicity profile activity.
Language: Английский
Citations
12Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(22)
Published: May 21, 2024
Current treatment options for diabetic wounds face challenges due to low efficacy, as well potential side effects and the necessity repetitive treatments. To address these issues, we report a formulation utilizing trisulfide-derived lipid nanoparticle (TS LNP)-mRNA therapy accelerate wound healing by repairing reprogramming microenvironment of wounds. A library reactive oxygen species (ROS)-responsive TS LNPs was designed developed encapsulate interleukin-4 (IL4) mRNA. TS2-IL4 LNP-mRNA effectively scavenges excess ROS at site induces expression IL4 in macrophages, promoting polarization from proinflammatory M1 anti-inflammatory M2 phenotype site. In model db/db mice, with this significantly accelerates enhancing formation an intact epidermis, angiogenesis, myofibroblasts. Overall, platform not only provides safe, effective, convenient therapeutic strategy but also holds great clinical translation both acute chronic care.
Language: Английский
Citations
12Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 256 - 275
Published: Oct. 25, 2022
Language: Английский
Citations
33Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 348, P. 672 - 691
Published: June 21, 2022
Language: Английский
Citations
32Dyes and Pigments, Journal Year: 2023, Volume and Issue: 211, P. 111089 - 111089
Published: Jan. 9, 2023
Language: Английский
Citations
23Colloids and Surfaces B Biointerfaces, Journal Year: 2023, Volume and Issue: 228, P. 113440 - 113440
Published: July 4, 2023
Language: Английский
Citations
23Advanced Materials, Journal Year: 2023, Volume and Issue: 36(4)
Published: Nov. 21, 2023
Abstract Homodimeric prodrug nanoassemblies (HDPNs) hold promise for improving the delivery efficiency of chemo‐drugs. However, key challenge lies in designing rational chemical linkers that can simultaneously ensure stability, self‐assembly and site‐specific activation prodrugs. The “in series” increase sulfur atoms, such as trisulfide bond, improve assembly stability HDPNs to a certain extent, but limits Herein, trithiocarbonate bond ( ─ SC(S)S ), with stable “satellite‐type” distribution is developed via insertion central carbon atom bonds. effectively addresses existing predicament by homodimeric prodrugs while maintaining on‐demand bioactivation. Furthermore, inhibits antioxidant defense system, leading up‐regulation cellular ROS apoptosis tumor cells. These improvements endow vivo longevity specificity, ultimately enhancing therapeutic outcomes. is, therefore, promising overcoming bottleneck efficient oncological therapy.
Language: Английский
Citations
18Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 677, P. 523 - 540
Published: Aug. 14, 2024
Language: Английский
Citations
7International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 639, P. 122942 - 122942
Published: April 9, 2023
Language: Английский
Citations
16